- Original Article
- Nephrology (Genitourinary)
- Urinary neutrophil gelatinase-associated lipocalin: a marker of urinary tract infection among febrile children
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Ji Hyun Moon, Kee Hwan Yoo, Hyung Eun Yim
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Clin Exp Pediatr. 2021;64(7):347-354. Published online October 17, 2020
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Question: Reliably diagnosing urinary tract infection (UTI) in febrile children is often difficult. Can urinary neutrophil gelatinase-associated lipocalin (uNGAL) better predict UTI and acute pyelonephritis (APN) than serum C-reactive protein (CRP) and white blood cell (WBC) count?
Finding: uNGAL better facilitated the prediction of UTI and APN, than serum CRP and WBC counts in febrile children.
Meaning: uNGAL is a suitable biomarker for UTI and APN in febrile children. |
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- Review Article
- Nephrology (Genitourinary)
- Obesity and chronic kidney disease: prevalence, mechanism, and management
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Hyung Eun Yim, Kee Hwan Yoo
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Clin Exp Pediatr. 2021;64(10):511-518. Published online April 6, 2021
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· Obesity is strongly associated with the development and progression of chronic kidney disease.
· Altered renal hemodynamics, metabolic effects, and lipid nephrotoxicity may play a key role in the development of obesity-related kidney disease.
· Children born to obese mothers are at increased risk of developing obesity and chronic kidney disease later in life.
· A multilevel approach is needed to prevent obesity and related chronic diseases. |
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- Case Report
- Nephrology (Genitourinary)
- Eosinophilic gastroenteritis in an 18-year-old male with prolonged nephrotic syndrome
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Da Min Choi, Jung Eun Pyun, Hyung Eun Yim, Kee Hwan Yoo, Jung Ok Shim, Eun Jung Lee, Nam Hee Won
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Clin Exp Pediatr. 2016;59(Suppl 1):S72-S75. Published online November 30, 2016
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Eosinophilic gastroenteritis is a rare disease characterized by prominent eosinophilic tissue infiltration of the gastrointestinal tract. Here, we report a case of eosinophilic gastroenteritis in an 18-year-old patient with prolonged nephrotic syndrome who presented with abdominal pain and peripheral hypereosinophilia. During the previous 2 years, he had visited local Emergency Department several times because of epigastric pain and nausea. He... |
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- Original Article
- Nephrology (Genitourinary)
- Impaired angiogenesis in the enalapril-treated neonatal rat kidney
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Hyung Eun Yim, Kee Hwan Yoo, Eun Soo Bae, Young Sook Hong, Joo Won Lee
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Clin Exp Pediatr. 2016;59(1):8-15. Published online January 22, 2016
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Purpose Nephrogenesis is normally accompanied by a tightly regulated and efficient vascularization. We investigated the effect of angiotensin II inhibition on angiogenesis in the developing rat kidney. MethodsNewborn rat pups were treated with enalapril (30 mg/kg/day) or vehicle (control) for 7 days after birth. Renal histological changes were checked using Hematoxylin & Eosin staining. We also investigated the intrarenal expression of vascular... |
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- Evaluation of new American Academy of Pediatrics guideline for febrile urinary tract infection
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Da Min Choi, Tae Hoon Heo, Hyung Eun Yim, Kee Hwan Yoo
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Clin Exp Pediatr. 2015;58(9):341-346. Published online September 21, 2015
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Purpose To evaluate the practical applications of the diagnosis algorithms recommended by the American Academy of Pediatrics urinary tract infection (UTI) guideline. MethodsWe retrospectively reviewed the medical records of febrile UTI patients aged between 2 and 24 months. The patients were divided into 3 groups: group I (patients with positive urine culture and urinalysis findings), group II (those with positive urine culture... |
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- Effect of angiotensin II inhibition on the epithelial to
mesenchymal transition in developing rat kidney
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Hyung Eun Yim, Kee Hwan Yoo, In Sun Bae, Young Sook Hong, Joo Won Lee
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Clin Exp Pediatr. 2009;52(8):944-952. Published online August 15, 2009
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Purpose:To investigate the effects of angiotensin II inhibition on the epithelial to mesenchymal transition (EMT) in the developing
kidney, we tested the expression of EMT markers and nestin in angiotensin converting enzyme (ACE) inhibitor-treated
kidneys.
Methods:Newborn rat pups were treated with enalapril (30 mg/kg/d) or a vehicle for 7 days. Immunohistochemistry for the
expression of α-smooth muscle actin (SMA), E-cadherin, vimentin, and nestin were... |
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- Evaluating and managing hypertension in children: a survey of Korean cardiologists and nephrologists
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Eun Hee Lee, Hyung Eun Yim, Gi Young Jang, Kee Hwan Yoo, Chang Sung Son, Young Sook Hong, Joo Won Lee
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Clin Exp Pediatr. 2008;51(9):992-997. Published online September 15, 2008
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Purpose : Hypertension (HTN) is no longer an exclusively adult disease; the prevalence of pediatric HTN is increasing. To understand the evaluation and treatment of childhood HTN in Korea, we investigated, via a questionnaire, how hypertensive children are currently assessed and managed by pediatric cardiologists (CA) and nephrologists (NE).
Methods : We surveyed 82 pediatric CA and 77 NE, regarding... |
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- Urinary tract infections in infants under six months of age
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Min Joo Kang, Hye Kyung Shin, Hyung Eun Yim, Bo-Kyung Je, So Hee Eun, Byung Min Choi, Jong-Tae Park, Baik Lin Eun, Kee Hwan Yoo
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Clin Exp Pediatr. 2006;49(3):278-286. Published online March 15, 2006
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Purpose : Although suprapubic bladder aspiration(SBA) is the most reliable technique for identifying
bacteriuria in young infant, no report has been published about the clinical manifestations of urinary
tract infection(UTI) diagnosed by aspirated urine in Korea. This study was performed to examine
clinical manifestations and related factors of UTI confirmed by a positive urine culture obtained by
SBA in young infants.
Methods : We reviewed... |
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- A Multivariate Analysis of Risk Factors of Renal Involvement in Henoch-Sch nlein Purpura
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Min Jee Jeoung, Hyung Eun Yim, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
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Clin Exp Pediatr. 2004;47(4):405-411. Published online April 15, 2004
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Purpose : Long-term prognosis of Henoch-Sch nlein purpura(HSP) is determined by the existence and severity of renal involvement. We evaluated the relationship between various clinical features of HSP and the development of renal involvement using univariate and multivariate analyses for early detection and proper management of HSP nephritis.
Methods : We performed a retrospective study of 200 children who were diagnosed... |
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- Case Report
- A Case of Intestinal Lymphangiectasia
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Hyung Eun Yim, Min Ji Jung, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
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Clin Exp Pediatr. 2003;46(9):921-925. Published online September 15, 2003
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Intestinal lymphangiectasia, one of the protein-losing gastroenteropathies, is an uncommon disease characterized by dilated intestinal lymphatics, enteric protein loss, edema, hypoalbuminemia, and lympocytopenia. Small bowel biopsy and CT have been used to confirm the diagnosis of intestinal lymphangiectasia. Small bowel biopsy shows collections of abnormal dilated lacteals in submucosa with distortion of villi and CT findings have been described as... |
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