- Original Article
- Characteristics of late-onset epilepsy and EEG findings in children with autism spectrum disorders
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Haneul Lee, Hoon Chul Kang, Seung Woo Kim, Young Key Kim, Hee Jung Chung
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Clin Exp Pediatr. 2011;54(1):22-28. Published online January 31, 2011
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Purpose To investigate the clinical characteristics of late-onset epilepsy combined with autism spectrum disorder (ASD), and the relationship between certain types of electroencephalography (EEG) abnormalities in ASD and associated neuropsychological problems. MethodsThirty patients diagnosed with ASD in early childhood and later developed clinical seizures were reviewed retrospectively. First, the clinical characteristics, language and behavioral regression, and EEG findings of these late-onset epilepsy... |
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- Electrocardiography as an early cardiac screening test in children with mitochondrial disease
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Ran Baik, Jung Hyun Chae, Young Mock Lee, Hoon Chul Kang, Joon Soo Lee, Heung Dong Kim
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Clin Exp Pediatr. 2010;53(5):644-647. Published online May 31, 2010
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Purpose To evaluate myocardial conductivity to understand cardiac involvement in patients with mitochondrial disease. MethodsWe performed retrospective study on fifty-seven nonspecific mitochondrial encephalopathy patients with no clinical cardiac manifestations. The patients were diagnosed with mitochondrial respiratory chain complex defects through biochemical enzyme assays of muscle tissue. We performed standard 12-lead electrocardiography (ECG) on all patients. ResultsECG abnormalities were observed in 30 patients (52.6%).... |
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- Ocular manifestations in Leigh syndrome
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Kyo Ryung Kim, Suk Ho Byeon, Young Mock Lee, Hoon Chul Kang, Joon Soo Lee, Heung Dong Kim
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Clin Exp Pediatr. 2010;53(2):163-166. Published online February 15, 2010
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Purpose : Leigh syndrome is a typical type of mitochondrial disease. This study was conducted to analyze the types of ophthalmologic symptoms and results of funduscopy conducted in the ophthalmologic examination of patients with Leigh syndrome.
Methods : Funduscopy was conducted on 24 subjects, who were chosen among those diagnosed as having mitochondrial respiratory chain complex defect and who were clinically... |
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- Risk factors of ocular involvement in children with mitochondrial respiratory chain complex defect
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Jung Hyun Chae, Jung Hun Lee, Kyo Ryung Kim, Suk Ho Byeon, Young Mock Lee, Hoon Chul Kang, Joon Soo Lee, Heung Dong Kim
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Clin Exp Pediatr. 2010;53(12):994-999. Published online December 31, 2010
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Purpose Mitochondrial dysfunction can present with various symptoms depending on the organ it has affected. This research tried to analyze the ophthalmologic symptoms and ophthalmologic examination (OE) results in patients with mitochondrial disease (MD). MethodsSeventy-four patients diagnosed with mitochondrial respiratory chain complex defect with biochemical enzyme assay were included in the study. They were divided into 2 groups based on the OE... |
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- Ictal single-photon emission computed tomography with slow dye
injection for determining primary epileptic foci in infantile spasms
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Yun Jung Hur, Joon Soo Lee, Hoon Chul Kang, Hye Jung Park, Mi Jin Yun, Heung Dong Kim
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Clin Exp Pediatr. 2009;52(7):804-810. Published online July 15, 2009
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Purpose : We investigated whether ictal single-photon emission computed tomography (SPECT) with prolonged injection of technetium-99m (99mTc) ethyl cysteinate dimer during repeated spasms can localize the epileptogenic foci in children with infantile spasms.
Methods : Fourteen children with infantile spasms (11 boys, 3 girls; mean age, 2.2¡¾1.3 years) were examined. When a cluster of spasms was detected during video electroencephalography (EEG)... |
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- Functional recovery after transplantation of mouse bone marrow-derived
mesenchymal stem cells for hypoxic-ischemic brain injury in immature rats
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Wooksun Choi, Hye Kyung Shin, So-Hee Eun, Hoon Chul Kang, Sung Won Park, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Baik-Lin Eun
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Clin Exp Pediatr. 2009;52(7):824-831. Published online July 15, 2009
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Purpose : We aimed to investigate the efficacy of and functional recovery after intracerebral transplantation of different doses of mouse mesenchymal stem cells (mMSCs) in immature rat brain with hypoxic-ischemic encephalopathy (HIE).
Methods : Postnatal 7-days-old Sprague-Dawley rats, which had undergone unilateral HI operation, were given stereotaxic intracerebral injections of either vehicle or mMSCs and then tested for locomotory activity in... |
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- The efficacy of ketogenic diet in childhood intractable epilepsy with malformation of cortical development
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Young-Mock Lee, Du Cheol Kang, Da Eun Chung, Hoon Chul Kang, Heung Dong Kim
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Clin Exp Pediatr. 2006;49(2):192-197. Published online February 15, 2006
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Purpose : Malformation of cortical development(MCD) constitutes an important etiology of intractable epilepsy and is considered an indication for surgical treatments, though their efficacy is limited and variable depending on MCD's location or distribution. Ketogenic diets are widely known to be effective, but as little study has been made concerning their efficacy on epilepsy with MCD, we evaluated the efficacy... |
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