Ghea Mangkuliguna, Edi Setiawan Tehuteru, Reganedgary Jonlean, Nicholas Adrianto, Stella Kallista
Clin Exp Pediatr. 2025;68(9):712-721. Published online July 4, 2025
Question: Does consolidative allogeneic stem cell transplantation (allo-SCT) after chimeric antigen receptor (CAR) T-cell therapy improve outcomes of children and young adult patients with relapsed/refractory hematologic malignancies? Finding: The meta-analysis showed reduced relapse rates and favorable survival trends with allo-SCT despite low evidence quality. Meaning: Consolidative allo-SCT after CAR T-cell therapy may enhance survival; however, further clinical studies are needed.