- Original Article
- Predictive factors for severe infection among febrile infants younger than three months of age
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Eun Young Cho, Hwa Song, Ae Suk Kim, Sun Ju Lee, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi, Kwan Lee, Byoung Chan Park
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Clin Exp Pediatr. 2009;52(8):898-903. Published online August 15, 2009
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Purpose:This study investigated the predictive factors for identifying infection-prone febrile infants younger than three months.
Methods:We conducted a retrospective study of 167 infants younger than three months with an axillary temperature >38℃
who were hospitalized between 2006 and 2008. If they met any of the following criteria, positive blood culture, CSF WBC ≥
11/mm3 or positive CSF culture, urinalysis WBC ≥6/HPF and positive... |
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- Assessment of parental understanding of epilepsy and effects of educational programs in an epilepsy camp
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Sung Min Cho, Soon Hak Kwon, Doo Kwun Kim, Jun Sik Kim, Han Koo Moon, Hye-Eun Se, Kye Hyang Lee, Eun Ju Lee, Jun Hwa Lee, Nho Eun Kim
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Clin Exp Pediatr. 2009;52(5):549-556. Published online May 15, 2009
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Purpose : To assess parental knowledge and understanding of epilepsy including social stigma and evaluate the effects of educational programs on parents in an epilepsy camp.
Methods : We conducted an epilepsy camp on August 23-24, 2008, at Gyeongsan. Twenty families with an epileptic child each participated in the camp. We performed a survey before and after the camp to... |
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- Case Report
- A Case of Hereditary C7 Deficiency Associated with Meningococcal Meningitis
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Hyun Woo We, Won Duck Kim, Sun Ju Lee, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi, Gyoung Yim Ha
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Clin Exp Pediatr. 2004;47(7):799-802. Published online July 15, 2004
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The complement system is composed of more than 25 different proteins and is usually divided into classical and alternative pathways. Complement component 7(C7) is one of the five terminal complement proteins that, upon activation of either the classical or the alternative pathway, interacts sequentially to form a large protein-protein complex, called membrane attack complex(MAC). Assembly of the MAC on target... |
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- Medical Lecture Course
- Recurrent Early-Life Seizures and Changes in GABAA Receptors Expression in Hippocampus
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Doo Kwun Kim
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Clin Exp Pediatr. 2004;47(6):596-603. Published online June 15, 2004
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The immature brain differs from the adult brain in its susceptibility to seizures, seizure characteristics, and responses to antiepileptic drugs. Gamma(γ)-aminobutyric acid(GABA) is the predominant inhibitory neurotransmitter in the adult brain. GABA exerts its main action through GABAA receptors, which are coupled to a ligand-gated chloride channel. The receptor protein is a pentameric structure composed of multiple subunits of different... |
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- Original Article
- Clinical and Virologic Study of Aseptic Meningitis
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Hyun Ji Kim, Hae Kwan Cheong, Cheoll Jung, Kyu Man Lee, Young Mee Jee, Won Duck Kim, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi
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Clin Exp Pediatr. 2004;47(4):392-398. Published online April 15, 2004
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Purpose : The cause of aseptic meningitis remains mostly unknown because viral culture and identification is difficult. Thus, we report a study on 123 children with aseptic meningitis in Gyeongju in 2002 to identify the causing virus and the relationship with the clinical manifestation.
Methods : We prospectively investigated the patients, admitted to Dongguk University Hospital, into two groups between April... |
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- Case Report
- A Case of Klippel-Trenaunay Syndrome Combinded with Sturge-Weber Syndrome
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Mi Young Kim, So Young Lee, Na Yeon Kim, Sun Ju Lee, Won Duck Kim, Sung Min Cho, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi
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Clin Exp Pediatr. 2003;46(9):909-912. Published online September 15, 2003
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Klippel-Trenaunay syndrome is a rare mesodermal phakomatosis characterized by cutaneous haemangiomata(usually unilateral and involving an extremity), venous varicosities and osseous and soft tissue hypertrophy, of the affected limb. Sturge-Weber syndrome, also a mesodermal pharkomatosis, is characterized by a port-wine nevus, which is present from birth and covers the face and cranium in the territory of the first division of the... |
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- Case Report
- A Case of Partial Inverted Duplication of Chromosome 7q
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Hyun Ji Kim, So Young Lee, Mi Young Kim, Chung Sun Baek, Won Duck Kim, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi
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Clin Exp Pediatr. 2003;46(5):510-513. Published online May 15, 2003
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Duplication of chromosome 7q has been reported as either partial or complete. Partial 7q duplication was first described by Carpentier in 1972. Pure partial duplication of the long arm of chromosome 7 is extremely rare and only 16 cases with a pure partial duplication of different 7q segment have been described in the literature. Pure partial duplication of the long... |
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- Chondrodysplasia Punctata(Rhizomelic Type)
Associated with Pneumothorax
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Ji Sun Mok, Hye Won Hwang, Jin Eun Kim, Dong Seok Lee, Doo Kwun Kim, Seong Min Choi
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Clin Exp Pediatr. 2001;44(8):965-970. Published online August 15, 2001
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Chondrodysplasia punctata is a rare congenital syndrome caused by a peroxisomal dysfunction. Chondrodysplasia punctata is classified into four main types-Coradi-Hunermann's type, rhizomelic type, X-linked dominant form and X-linked recessive form. A male patient with this condition was born at 39 weeks gestation, the pregnancy being complicated by polyhydroamnios, breech presentation, and anomalies of congenital limbs. At delivery, there was no... |
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- A Case of Aseptic Meningitis Following Administration of Intravenous Immunoglobulin in A Patient with
Idiopathic Thrombocytopenic Purpura
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Su Jin Kim, Ji Eun Kim, Hei Won Hwang, Ji Sun Mok, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi, Woo Taek Kim
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Clin Exp Pediatr. 2001;44(7):823-826. Published online July 15, 2001
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Intravenous immunoglobulin(IVIG) has been widely used to treat idiopathic thrombocytopenic purpura in childhood. Aseptic meningitis has been reported as a rare complication of IVIG therapy. This report is on an 11 year-old boy with ITP who suffered from aseptic meningitis following the administration of IVIG. He was given 1 g/kg of IVIG for 2 days, and on the fourth day... |
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- Two Cases of Leigh Disease in Siblings
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Su Jin Kim, Ji Eun Kim, Hei Won Hwang, Ji Sun Mok, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi, Woo Taek Kim
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Clin Exp Pediatr. 2001;44(6):718-722. Published online June 15, 2001
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Leigh disease is a familial and degenerative disorder characterized by focal, bilateral, and usually symmetric lesions of the both gray and white matter in the brain and the spinal cord. The clinical course is variable, but in most cases, the prognosis is poor with subacute progression leading to death within months or years of life. The pathogenesis was known as... |
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- Original Article
- A Clinical Study of Intravenous Gamma Globulin Re-treatment
in Kawasaki Disease
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Na Yeon Kim, Chun Hyuk Chang, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi, Woo Taek Kim
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Clin Exp Pediatr. 2000;43(2):223-228. Published online February 15, 2000
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Purpose : Intravenous gamma globulin(IVGG) treatment has reduced symptoms and complications in Kawasaki disease(KD). However, fever persisted in 20-30% of the patients, and there are no reliable data on the indication and dosage of IVGG re-treatment. Therefore, we tried to reveal the effectiveness of IVGG re-treatment and to find risk factors in predicting the re-treatment.
Methods : Among 57 patients with... |
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- The Role of Nitric Oxide in Seizures Induced by Pentylenetetrazole
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Jun Ho Kim, Doo Kwun Kim
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Clin Exp Pediatr. 2000;43(10):1356-1363. Published online October 15, 2000
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Purpose : Nitric oxide(NO) is a highly reactive messenger molecule that is synthesized by nitric oxide synthase(NOS) in a number of tissues including the brain. Our aim was to examine the possible role of NO on pentylenetetrazole(PTZ)-induced seizure in rats as a proconvulsant or an anticonvulsant.
Methods : Male Sprague-Dawley rats weighing 200-300g were used. PTZ(40mg/kg) was used to induce seizure.... |
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- Case Report
- A Case of Ectopic CD7(+) Congenital Monocytic Leukemia
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Na Yeon Kim, Dong Seok Lee, Jin Hwa Jeong, Sung Min Cho, Doo Kwun Kim, Sung Min Choi, Woo Taek Kim, Kyung Im Ha
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Clin Exp Pediatr. 1999;42(7):1003-1007. Published online July 15, 1999
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Congenital acute leukemia is a rare disorder with approximately 200 cases reported. It is defined as a childhood leukemia occurring at birth or before 1 month of age at a rate of 1%. Acute leukemias are generally classified according to morphology, cytochemistry and cell surface marker expression. Most leukemias conform to an ordered lineage-specific pattern of gene expression, but a... |
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- A Case of Nonsyndromic Paucity of Interlobular Bile Ducts in Down Syndrome
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Chun Hyuk Chang, Jun Ho Kim, Sun Ju Le, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi, Woo Taek Kim, Tae Jung Jang
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Clin Exp Pediatr. 1999;42(6):858-862. Published online June 15, 1999
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The nonsyndromic paucity of interlobular bile ducts, which belongs to intrahepatic biliary atresia, is characterized by conjugated hyperbilirubinemia, suggesting cholestasis in newborn infants it has little relationship with extrahepatic congenital abnormalities.
Pathologic findings through percutaneous liver biopsy show portal changes(duct paucity and fibrosis) and lobular changes(cholestasis, giant cell transformation, extramedullary hematopoiesis and perisinusoidal fibrosis). The overall incidence of intrahepatic biliary... |
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- Original Article
- Study of Nosocomial Infection of Rotavirus in Preterm and Full-term Neonates
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Kwang Ok Chung, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi, Woo Taek Kim, Sun Hee Yu
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Clin Exp Pediatr. 1999;42(3):332-338. Published online March 15, 1999
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Purpose : The present study was designed to investigate rotavirus infection by comparing clinical characteristics of the nosocomial infection of rotavirus between preterm and full-term neonates.
Methods : The subjects were admitted from May to December, 1996. In 71 preterms, 44 were Rotazyme positive, 27 were negative, and in 321 full-terms, 64 were Rotazyme positive, 257 were negative. We studied the... |
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- Effects of Hyperthermia on Neuronal Nitric Oxide Synthase Expression after Cerebral Ischemia in Gerbils
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Doo Kwun Kim, Duk Joon Suh
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Clin Exp Pediatr. 1999;42(11):1542-1551. Published online November 15, 1999
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Purpose : This study was aimed to elucidate the effect of hyperthermia on neuronal nitric oxide synthase(nNOS) expression in both cerebral hemispheres after left common carotid artery occlusion in gerbils.
Methods : Using Mongolian gerbils, cerebral ischemia was produced by occluding carotid artery for 1-4 hours. Rectal temperature was maintained at 36℃ for normothermia and 40℃ for hyperthermia by heating pad.... |
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- Case Report
- A Case of Neonatal Hyperthyroidism with Unilateral Ear Anomaly
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Kwang Ok Chung, Na Yeon Kim, Sung Min Cho, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi
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Clin Exp Pediatr. 1998;41(6):845-849. Published online June 15, 1998
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Neonatal hyperthyroidism is a very rare disorder occurring typically in the offspring of patients
with Graves' disease or chronic thyroiditis. It is caused by the transplacental passage of thyroid
stimulating antibodies(TSAb) from the mother to the fetus. There has been few reports of
neonatal hyperthyroidism associated with congenital anomalies.
We experienced a case of neonatal hyperthyroidism with unilateral microtia and agenesis of
external auditory canal... |
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- Original Article
- Retrospective 3-year Clinical Study of Enterobacter Bacteremia in Neonatal Intensive Care Unit
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Kwang Ok Chung, Chun Hyuk Chang, Sung Min Cho, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi
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Clin Exp Pediatr. 1998;41(4):466-471. Published online April 15, 1998
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Purpose : Enterobacter is one of the important organisms in neonatal intensive care unit. We
reviewed the clinical characteristics, underlying diseases, invasive procedures during admission,
mortality and antibiotic sensitivity of Enterobacter infection in NICU.
Methods : We retrospectively reviewed 21 neonatal patients whose blood cultures yielded
Enterobacter between June 1994 and June 1997 at Dongguk University Hospital.
Results : Blood cultures were positive in 62... |
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- Case Report
- A Case of Lacquer-Thinner Intoxication
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Young Soo Baik, Hee Sin Ko, Kyung Bae Kwon, Doo Kwun Kim, Sung Min Choi, Woo Taek Kim, Jeong Ok Choi, Hyun Jong Sin
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Clin Exp Pediatr. 1995;38(5):713-718. Published online May 15, 1995
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We experienced a case of Lacquer-Thinner intoxication in a 14 month old male infant who s uffered from aspiration pneumonia, gastrointestinal bleeding, acute hepatitis, acute renal failure, respiratory failure, disseminated intravascular coagulopathy, and focal myoclonic seizure.
Lacquer-Thinner is composed of toluene, xylene, methyl ethyl ketone, n-butyl alcohol, ethylene glycol monoethyl ether, and isophorone. The main components are toluene and xylene. Th... |
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