Clinical and Experimental Pediatrics

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Chun Mae Jin (Jin CM)

1 Article

Original Article

Anti-tumor effect of new compound, 127, through the induction of apoptosis

Ki Hwan Baek, A Lum Han, Sae Ron Shin, Chun Mae Jin, Young Wook Yoon, Seung Taek Yu, Jong Duk Kim, Du Young Choi

Clin Exp Pediatr. 2009;52(6):696-700. Published online June 15, 2009

Purpose : We screened more than 350 compounds with an endoperoxide ring structure in search of an anti-leukemic drug and found that compound 127 (c-127) could induce significant cytotoxicity in HL-60 cells. In this study, we investigated the molecular mechanisms of compound 127-induced antitumor activity on HL-60 cells. Methods : HL-60 cells were cultured in Rosewell Park Memorial Institute 1640...

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