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Original Article
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Korean parents’ perceptions of the challenges and needs on school re-entry during or after childhood and adolescent cancer: a multi-institutional survey by Korean Society of Pediatric Hematology and Oncology
Jun Ah Lee, Jae Min Lee, Hyeon Jin Park, Meerim Park, Byung Kiu Park, Hee Young Ju, Ji Yoon Kim, Sang Kyu Park, Young Ho Lee, Ye Jee Shim, Heung Sik Kim, Kyung Duk Park, Yeon-Jung Lim, Hee Won Chueh, Ji Kyoung Park, Soon Ki Kim, Hyoung Soo Choi, Hyo Seop Ahn, Jeong Ok Hah, Hyoung Jin Kang, Hee Young Shin, Mee Jeong Lee
Clin Exp Pediatr. 2020;63(4):141-145.   Published online November 14, 2019
Question: What are the parental needs and challenges when their children return to school after cancer?
Finding: In addition to scholastic aptitude-oriented programs, emotional and psychosocial support is necessary for a successful return to school.
Meaning: Pediatric oncologists should actively engage in improving oncology practices to better integrate individualized school plans and educate peers and teachers to improve health literacy to make them understand the needs of children with cancer.
Case Report
Oncology
Targeted busulfan and fludarabine-based conditioning for bone marrow transplantation in chronic granulomatous disease
Hee Young Ju, Hyoung Jin Kang, Che Ry Hong, Ji Won Lee, Hyery Kim, Sang Hoon Song, Kyung-Sang Yu, In-Jin Jang, June Dong Park, Kyung Duk Park, Hee Young Shin, Joong-Gon Kim, Hyo Seop Ahn
Clin Exp Pediatr. 2016;59(Suppl 1):S57-S59.   Published online November 30, 2016

Chronic granulomatous disease (CGD) is a primary immunodeficiency disease caused by impaired phagocytic function. Hematopoietic stem cell transplantation (HSCT) is a definitive cure for CGD; however, the use of HSCT is limited because of associated problems, including transplantation-related mortality and engraftment failure. We report a case of a patient with CGD who underwent successful HSCT following a targeted busulfan and...

Hemophagocytic lymphohistiocytosis diagnosed by brain biopsy
Hee Young Ju, Che Ry Hong, Sung Jin Kim, Ji Won Lee, Hyery Kim, Hyoung Jin Kang, Kyung Duk Park, Hee Young Shin, Jong-Hee Chae, Ji Hoon Phi, Jung-Eun Cheon, Sung-Hye Park, Hyo Seop Ahn
Clin Exp Pediatr. 2015;58(9):358-361.   Published online September 21, 2015

Hemophagocytic lymphohistiocytosis (HLH) is characterized by fever, splenomegaly, jaundice, and pathologic findings of hemophagocytosis in bone marrow or other tissues such as the lymph nodes and liver. Pleocytosis, or the presence of elevated protein levels in cerebrospinal fluid, could be helpful in diagnosing HLH. However, the pathologic diagnosis of the brain is not included in the diagnostic criteria for this...

Original Article
Pulmonary tuberculosis misdiagnosed as lung Metastasis in childhood cancer patients
Hyun Rae KK, Dong Whand Lim, Kang Min, Kyung Duk Park, Jun Ah Lee, Soo Yeon Cho, Yoon Hoh Kook, Hee Youn Kim, Dong Ho Kim
Clin Exp Pediatr. 2009;52(8):904-909.   Published online August 15, 2009

Purpose:The differential diagnosis for a pulmonary nodule is intriguing in cancer patients. Metastasis might be a preferential diagnosis, and yet possibilities of other medical conditions still exist. Pulmonary tuberculosis should be enlisted in the differential diagnosis for a pulmonary nodule in cancer patients in Korea. This study was aimed at analyzing the incidence and clinical features of pulmonary tuberculosis that were misdiagnosed as...
Bilateral retinoblastoma: Long-term follow-up results from a single institution
Sang Yul Choi, Dong Hwan Kim, Kang Min Lee, Hyun Jae Lee, Mi-Sook Kim, Tai-Won Lee, Sang Wook Choi, Dong Ho Kim, Kyung Duk Park, Jun Ah Lee
Clin Exp Pediatr. 2009;52(6):674-679.   Published online June 15, 2009
Purpose : The authors aimed to analyze the long-term effects of treatments, especially external beam radiotherapy (EBRT), in bilateral retinoblastoma patients. Methods : This retrospective study analyzed the medical records of 22 bilateral retinoblastoma patients who were registered between October, 1987 and October, 1998 and followed-up for more than 10 years. They were treated by enucleation, EBRT, and systemic chemotherapy....
Serum methotrexate level is inversely related to the outcome of osteosarcoma patients
Jun Ah Lee, Min Suk Kim, Jin Kyung Lee, Dong Ho Kim, Young Joon Hong, Won Seok Song, Wan Hyeong Cho, Soo-Yong Lee, Jung Sub Lim, Kyung Duk Park, Dae-Geun Jeon
Clin Exp Pediatr. 2009;52(5):581-587.   Published online May 15, 2009
Purpose : To evaluate the correlation between serum methotrexate (MTX) peak levels and clinical outcome of osteosarcoma, as well as to determine the correlation of these levels with the histologic response and event-free survival (EFS). Methods : To maintain the homogeneity of the study population, we selected 52 patients with localized extremity osteosarcoma who had received two cycles of neoadjuvant...
Clinical significance of loss of p16 protein by immunohistochemical staining in acute lymphoblastic leukemia
Hye Young Jin, Kyoung In Kang, Sun Young Kim, You Sook Youn, Joon Won Kang, Deog Yeon Jo, Kye Chul Kwon, Kyung Duk Park
Clin Exp Pediatr. 2008;51(1):73-77.   Published online January 15, 2008
Purpose : p16 gene, mapped to the 9p21 chromosomal region, has emerged as a candidate tumor suppressor gene in human neoplasm. It is an inhibitor of cyclin-dependent kinase and inhibits Rb phosphorylation. In a variety of tumors including childhood acute lymphoblastic leukemia (ALL), deletion and/or mutation of the p16 gene has been found. Despite their high frequency, the prognostic importance...
Clinical Evaluation of Tissue Biopsy for Children with Neck Mass; A Single Center Study
You Sook Youn, Hye Won Yoon, Sun Young Kim, Ji Young Sul, Chang Jun Song, Jin Man Kim, Kyung Duk Park
Clin Exp Pediatr. 2005;48(8):839-845.   Published online August 15, 2005
Purpose : Neck masses, in pediatric population, derive from a multitude of congenital, inflammatory, or neoplastic diseases. The majority of these masses represent benign conditions. However, thorough clinical evaluation is required to rule out malignant diseases. We evaluated the causes, clinical characteristics and outcomes of children with neck masses who underwent tissue biopsy. Methods : A total of 28 medical records...
Clinical and Cytogenetic Analysis of Children with Maternal Chromosomal Balanced Translocation
Han Hyuk Lim, Hee Jeong Jeong, Kyung Duk Park, Sook Ja Kim
Clin Exp Pediatr. 2005;48(7):701-705.   Published online July 15, 2005
Purpose : Parents' genetic information plays an important role in their children's genetic expression. Human chromosome has 23-paternal chromosomes and 23-maternal chromosomes. Parental chromosomal translocation can induce clinical problems in their children because of imbalance in genetic information. We intent to analyze the cytogenentic and clinical features about children with maternal balanced translocation between chromosome 15 and 18. Methods :...
Protein C as a Differential Marker for Bacterial Infection among Pediatric Patients with Fever
Eun Ha Mo, In Hae Nam, Kyung Duk Park
Clin Exp Pediatr. 2004;47(8):839-843.   Published online August 15, 2004
Purpose : This study was performed to find the clinical significance in protein C as a differential marker in the beginning stage of infection and prognosis factor in severe infection among pediatric patients who were admitted due to fever. Methods : A total of 40 pediatric patients who had temperatures higher than 37.5℃ on admission at the Department of Pediatrics,...
Medical Lecture Course
Recent Advances of Adoptive Immunotherapy to Prevent CMV Disease after Allogeneic Stem-cell Transplantation
Kyung Duk Park
Clin Exp Pediatr. 2003;46(5):418-422.   Published online May 15, 2003
Original Article
Results of Chemotherapy of Hepatoblastoma and Hepatocellular Carcinoma in Children
Kyung Duk Park, Gi Woong Seong, Jae Kyung Lee, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1995;38(2):195-206.   Published online February 15, 1995
Purpose : Surgical excision has been the primary treatment for hepatoblastoma and hepatocellular carcinoma. However, at presentation, only one third of such tumors are surgically resectable. Without operation, the disease is fatal. Therefore, neoadjuvant chemotherapy has been introduced for conversion of the unresectable tumors into the resectable ones. We studied th e effects of chemotherapy for hepatic malignancy in children. Methods...
A Prospective Study of Totally Implanted Venous Access System in 19 Children with Cancer
Kyung Duk Park, Eun Sil Dong, Seong Hoon Ha, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn, Seong Eun Jun, Gui Won Park
Clin Exp Pediatr. 1993;36(5):687-692.   Published online May 15, 1993
A totally implanted venous access system was inserted in 19 children with cancer. The devices were utilized for the administration of antineoplastic drug, parenteral fluids, antibiotics, and blood products. Total duration of implantation was 4,046 days for 23 implanted system (range 7-445 days). Complications included cather infection (0.247/100 catheter day), occlusion (0.692/100 catheter days), and dislodgement of needle (0.643/100 catheter...
Carcinomas in Childhood -A 10-Year Experience in Seoul National University Hospital-
Hong Hoe Koo, Kyung Duk Park, Hye Lim Jung, Sang Kyu Park, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1992;35(10):1369-1376.   Published online October 15, 1992
Carcinomas in childhood differ from those in adults in their frequency, histologic type, and distribution of primary sites. In children, carcinomas are rare and few series have been published containing sufficient mumbers of cases to permit a reliable account of the incidence and survival of children with carcinoma. During a 10-year period, 1982-1991, we observed 40 patients less than 16...
Case Report
Three Cases of Brain Tumors with Bone Metastasis
Eun Joo Kim, Kyung Duk Park, Eun Sil Dong, Hye Jung Park, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn, Je Geun Chi
Clin Exp Pediatr. 1992;35(3):381-389.   Published online March 15, 1992
Medulloblastoma and primitive neuroectodermal tumor(PNET) are relatively common intracranial neoplasms in childhood. Their extracranial metastasis were thought to be rare occurrences. But they are more frequent compared to other intracranial tumors. The most frequent site of metastasis deposits in medulloblastoma is bone, and metastasis to lymph node, peritoneum, liver or lung have been reported infrequently. The authors experienced three cases...
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