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Original Article
A Case of Virus Associated Hemophagocytic Syndrome.
Yang Soo Kang, Ue Chong Yang, Hae Il Cheoung, Ho Jin Park, Mi Ja Shin, Je Geun Chi
Clin Exp Pediatr. 1989;32(4):567-575.   Published online April 30, 1989
Virus associated hemophagocytic syndrome is a rare hemophagocytic disorder, apparently associated with active viral infection, apparently associated with active viral infection, in which reactive histiocytes proliferate in the reticuloendothelial system, mainly bone marrow and medullary portions of lymph nodes, as a non-malignant, reversible but potentially constitutional symptoms with high fever and hepatosplenomegaly and by laboratory findings of pancytopenia, hemophagocytosis, abnormal liver function and coagulopathy. Inappropriate immunosuppressive...
Clinical Studies of Urinary Tract Infection in Infant and Children.
Kee Sung Yang, Mi Soo Ahn, Hong Bae Kim, Ji Sub Oh
Clin Exp Pediatr. 1989;32(4):533-541.   Published online April 30, 1989
Clinical studies on the 82 patients of sympomatic urinary tract infection who were admitted to pediatric department of Wallace Memorial Baptist Hospital from August 1984 to July 1987 were subjected in this study. The result were as follows. 1) The incidence was 0.79% of total pediatric inpatients during the same period. 2) Age incidence disclosed under 1 year in 49 patients(59.7%) and under 6 year...
A Case Posttraumatic Parkinsonism.
Young Wan Kim, Chang Jun Coe
Clin Exp Pediatr. 1989;32(3):438-443.   Published online March 31, 1989
We experienced a case of parkinsonism in a 6 year 4 month old boy who sustained basal skull fracture after outcar accident. The clinical features and response to therapy were described with brief literature review.
A Case of Congenital Megakaryoblastic Leukemia Accompanied by Down Syndrome Which was Diagnosed by Autopsy Findings.
Il Kyung Kim, Dong Beom lee, Jung Sik Min, Chang Hee Choi, Je Geun Chi
Clin Exp Pediatr. 1989;32(2):262-269.   Published online February 28, 1989
Many cases of acute megakaryonlastic leukemia have been reported in childhood or adults, but congenital form or the cases occuring in neonatal period is very rare throughout the world. In Korea only one case was reported previously by Chung et al in 1987. The authors experienced a case of congenital megakaryoblastic leukemia accompanied by Down' s syndrome, which was confirmed by autopsy and positive...
A Clinical Study on Peptic Ulcer in Childhood.
S L Lee, Y S Kim, E S Suh, T W Paik, C M Kang
Clin Exp Pediatr. 1989;32(2):198-205.   Published online February 28, 1989
Although many papers about peptic ulcer disease in childhood has stated that the condition is increasing in incidence during the past several years, still the condition is not frequently recognized in childhood compared with the incidence in adults. Authors carried out the clinical analysis on 35 patients with peptic ulcer under the age of 15 years who were admitted to pediatric department of Dong...
Clinical Observations of Meningitis.
Byoung Hoon Lee, Hyung Keun Nam, Myung Ik Lee, Keun Chan Sohn
Clin Exp Pediatr. 1989;32(2):180-190.   Published online February 28, 1989
The 267 cases of meningitis were observed at National Medical Center between Jan. 1st 1979 and May 31, 1986. The results were as follow; 1) In BM and TM sexual difference was not notice, but male was more in AM. 2) In BM infancy was the most common, but school age was common was AM. 3) Most cases developed during spring in BM and TM...
A Case of Testicular Tumor Metastasized to The Lung.
Jong Sik Kim, Dae Young Kim, Kang Ho Kim, In Kwyu Park, Young Bong Park, Chang Soo Ra
Clin Exp Pediatr. 1989;32(1):137-142.   Published online January 31, 1989
A 11/2 year old male child was admitted to the Department of Pedíatrics of Chosun University Hospital because of dyspnea and coughíng. on physical examination, intercostal and subcostal retraction were observed, and dullness and decreased breathing sound were auscultated on the right side chest. Seven months earlier, the patient developed a mass on the right side testis and has grown rapidly and was admitted to...
A Case of Metastatic Ganglioneuroblastoma.
Ghee Young Jung, Chin Sam Ro, Ki Ung Hong, Yun Jung Kim, Eun Kyung Hong, Moon Hyang Park
Clin Exp Pediatr. 1989;32(1):121-129.   Published online January 31, 1989
Ganglioneuroblastoma is a malignant tumor which contains characteristics of both the neuroblastoma and the ganglioneuroma. It may be invasive and metastasized to the distant organs. We experienced a case of ganglioneuroblastoma which was arised from the left adrenal gland and metastasized to the left femur and the bone marrow. A 3 year old male patient was diagnosed as ganglioneuroblastoma and confirmed histologically A review of literatures...
Angioimmunoblastic Lymphadenopathy in a Child.
S J Lee, H S Lee, H S Kim, C M Kang, D S Kim
Clin Exp Pediatr. 1988;31(12):1669-1673.   Published online December 31, 1988
Angioimmunoblastic lymphadenopathy is a lymphoma like disorder consisting of generalized lymphadenopathy, hepatosplenomegaly, skin rashes, often associated with dysgammag- lobulinemia. We have experienced recently 3 year old female complaining of generalized lymphadenopthy, fever, hepatomegaly and hypergammaglobulinemia, and was proved as angioimmunoblastic lymphadenopathy histologically. Patient was treated with combined chemotherapy with COMP and responded well clinically in 4 months. The brief review of the literature was made.
Pancreatic ISlet-cell Adenoma in a Neonate.
Kyu Bum Cho, Yang Bin Im, Dong Hwan Lee, Sang Jhoo Lee, Tae Jeong Kwon, Dong Hwa Lee
Clin Exp Pediatr. 1988;31(12):1650-1656.   Published online December 31, 1988
Islet cell adenoma is a rare cause of severe neonatal hypoglycemia. A newborn infant with severe symptomatic hypoglycemia had persistent hypoglycemia in spite of therapy with parenteral glucose solution. Islet-cell adenoma of mixed islet-acinar type was found when subtotal pancreatectomy was performed at 42 days of age. Following surgery she had a transient hyperglycemia and required isulin for 40 days. She has remained normoglycemic but...
The Direct Coombs Test and Heat Elution Test in ABO Incompatible Hemolytic Disease of the Newborn.
Kook In PArk, Chul Lee, Ran Namgung, Dong Gwan Han, Kir Young Kim
Clin Exp Pediatr. 1988;31(12):1633-1640.   Published online December 31, 1988
The clinical study on 28 cases of ABO HDN who were diagnosed at Pediatric Department of Severance hospital and Yong Dong Severance hospital, Yonsei University for last 5 months was. And in these cases, heat elution test in combined with direct Coombs test using standard techniques were performed to evaluate the clinical significance of serological diagnosis. The following results were obtained. 1) Of 28 ABO HDN...
A Case of Infantile Cortical Hyperostosis.
Jae Kyoun Rhim, Young Hyuk Lee, Chang Jun Coe, Duk Jin Yoon
Clin Exp Pediatr. 1988;31(11):1494-1498.   Published online November 30, 1988
Recently we have experienced a case of infantile cortical hyperostosis. The patients was 2 months old male who complained irritability, soft tissue swelling of both lower extremities. X-ray showed periosteal new bone formation on both tibiae. Bone scan revealed hot uptake at the lesion. We are reporting this infantile cortical hyperostosis with reviewing literatures.
Histiocytic Medullart Reticuloisis in Children.
Duck Kyu Kim, Jung Hyun Park, Ok Ji Hwang, Ja Ye Kim, Woo Kap Chung, Kye Sook Lee
Clin Exp Pediatr. 1988;31(9):1217-1224.   Published online September 30, 1988
Histiocytic medullary reticulosis (HMR) is a clinicopathologic syndrome characterized by its acute onset and relentless progression to death within a few months. Major clinical features are fever, wasting, generalized lymphadenopathy and hepatosplenomegaly. In the terminal stages, Jaundice, purpura, anemia and leukopenia are common. Cardinal pathologic features are diffuse proliferation of atypical, neoplastic, erythrophagocytic histiocytes and their precursors throughout the reticuloen- dothelial system. Here, we present 2...
Lipoproteinelectropheresis pattern in Nephrotic Syndrome.
Soon Don Hong, Byung Soo Cho, Chang Il Ahn
Clin Exp Pediatr. 1988;31(9):1163-1170.   Published online September 30, 1988
This study was undertaken to eluidate lipoprotein patterns in patients with childhood nephrotic syndrome by response to initial steroid therapy, serum albumin level in MCNS and other histologic classifications. The result were summerized as follows. 1) There were 19 cases (52.8%) of abnormal lipoprotein patterns by Fredrickson classifications, type Ila were 6 cases (16.7%), type lib were 1 cases (2.8%) and type IV were 12 cases...
ABO Gene Frequency in ABO Hemolytic Disease of Newborn.
Young Mi Hong, Keun Lee
Clin Exp Pediatr. 1988;31(9):1105-1113.   Published online September 30, 1988
ABO hemolytic disease in newborn due to ABO incompatibility between mother and infant is one of common cause of neonatal hyperbilirubinemia and early detection has been emphasized due to its possible neurologic sequelae. Many studies reported prevalence difference of ABO hemolytic disease in various races, which could be ascribed to different frequency of ABO genes in races. From Feb. 1986 to May 1987 full...
A Case of Acute Megakaryoblastic Leukemia in Infant with Down's Syndrome.
Jung Soon Whang, Soon hee Kim, Moon Ja Kim, Keun Lee, Je Geun Chi
Clin Exp Pediatr. 1988;31(8):1064-1070.   Published online August 31, 1988
Acute megakaryoblastic leukemia is an uncommonly recognized disorder that is characterized by rapidly progressive proliferation of atypical megakaryocytes and their precursor cells, and fatal course. Abnormalities in chromosome 21 may have a more than random relationship to acute megakaryoblastic leukemia. The authors reports a case of acute megakaryoblastic leukemia in a 2 month old female patient who was admitted for evaluation of hepatosplenomgaly. Multiple organ infiltration...
A Case of Hemolytic Disease of Newborn due to Anti-E.
Sang Keun Oh, Youn O Park, hyun Sook Seo, Mi Sook Park, Young Chul Lee, Hee Dae Park, Hee Joo Lee
Clin Exp Pediatr. 1988;31(8):1059-1063.   Published online August 31, 1988
A 2-day-old male infant was admitted to the Incheon Christian Hospital due to severe jaundice. He was a third baby and his Rh phenotype was CcDEe. The direct antiglobulin test of the infant was strong positive. Eluates that were made from the infanfs elder brother and sister were both CDe. Her two previous infants showed no evidence of erythroblastosis. She had a past...
Thyriod Function Studies in Children with Nephrotic Syndrome.
In Hoon Lee, Chan Yung Kim
Clin Exp Pediatr. 1988;31(8):1037-1047.   Published online August 31, 1988
To evaluate the influence of nephrotic syndrome on the thyroid function test in children, serum T3, T4, free T4, TSH, TBG and rT3 were measured using radioimmunoassay in 14 clinically euthyroid children with nephrotic syndrome who were admitted to Department of Pediatrics, Pusan National University Hospital from July, 1986 to August, 1987. Control group was 15 children who visit our outpatient department for minor...
Goiter in Children.
Young Wan Kim, Duk Hi Kim, Byeung Ju Jeoung
Clin Exp Pediatr. 1988;31(8):1028-1036.   Published online August 31, 1988
We studied 197 cases of patients with goiter who visited Department of Pediatrics, Yonsei University College of Medicine from January 1980 to June 1987. For each patient, serum T4, free T4, T3, TSH, antithyroid antibody, and antimicrosomal antibody were analyzed, thyroid scan was performed, and radioiodine uptake was measured. Following results were obtained: 1) Male to female ratio of 197 cases of goiter was 1:7.5, predominent...
Plasma Renin Activity (PRA) in Peripheral Vein and Renal Veins in Normotensive Children with Cyanotic Congenital Heart Disease.
Sang Kyu Park, Hae Il Cheong, Chung Il Noh, Yong Soo Yun, Yong Choi, Kwang Wook Ko
Clin Exp Pediatr. 1988;31(8):1021-1027.   Published online August 31, 1988
PRA’s in peripheral vein, both renal veins, and inferior vena cava (IVC) were measured in 25 normotensive children without renal disease undergoing cardiac catheterization for their underlying cyanotic congenital heart disease. And we presented the results as reference values/ranges of PRA in children. 1) There was no significant difference in PRA between both side renal veins at any absolute PRA levels with a mean ratio (RT/LT)...
A Study of Maternal IgG Anti-A, B in ABO Hemolytic Disease of Newborn: Relation between Antibody titer in Mother and Clinical Severity in Neonate.
Chong Woo Bae, yong Mook Choi, Chang Il Ahn, Hyun Sook Chi
Clin Exp Pediatr. 1988;31(8):999-1006.   Published online August 31, 1988
Only IgG anti-A, or Anti-B cross the placenta and are responsible for the occurrence of ABO hemolytic disease of newbom(HDN). We have conducted the role of IgG anti-A or anti-B in mothers to occurrence and severity of the disease with were related to the level of antibodies in pathogenesis of ABO-HDN. This report presents the relation between the degree of bilirubin, hemoglobin concentration in ABO-HDN...
Statistical Assessment on Chromosomal Aberrations observed on Childhood.
Seong Ho Kim, Jeh Hoon Shin, Soo Jee Moon, Hahng Lee, KeunSoo Lee, Youl Hey Cho, Myung So Ryu, Young Kyun Paik
Clin Exp Pediatr. 1988;31(8):977-983.   Published online August 31, 1988
Chromosomal studies were carried out in 730 patients at the Dept, of Pediatrics and Genetics, Hanyang University Hospital, form December 1979 to April 1986. A statistical assessment was carried out in 244 cases who have chromosomal aberrations. The following results were obtained: 1) Chromosomal aberrations were observed in 244 cases among 730 cases, so the propotion of chromosomal aberrations was 33%. 2) Age distribution revealed 53% of chromosomal...
A Prospective Study of Urinary beta2 -Microglobulin in Infants with Meconium-Stained Amniotic Fluid.
Sung Oh Kim, Jeh Hoon Shin, Woo Gill Lee, Soo Jee Moon, Keun Soo Lee
Clin Exp Pediatr. 1988;31(8):968-976.   Published online August 31, 1988
We studied prospectively whether events that result in meconium staining may be associated with additional abnormalities that are not clinically apparent associated by measurements of urinary concentrations of β₂-microglobulin indicating renal proximal tubular functions. Among 61 fullterm, healthy neonates delivered at Hanyang University Hospital during the period of September 1986 through April 1987, urinary concentration of β₂-microglobulin and creatinine were measured during the immediate perinatal...
A Case of Cleidocranial Dysostosis with Leukemia.
Baik Lin eun, Si Hun Han, Young Sook Hong, Soon Kyum Kim
Clin Exp Pediatr. 1988;31(7):930-934.   Published online July 31, 1988
Cleidocranial dysostosis is a rare, inherited abnormality which affects the development of mem- bransous and cartilaginous bone. Authors report a case of cleidocranial dysostosis with leukemia in a 10 year old boy. The review of the literature was made briefly.
7 Cases of Group B Streptococcal Meningitis and Sepsis.
Young Wan Kim, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1988;31(7):873-880.   Published online July 31, 1988
We report 7 cases of Group B streptococcal meningitis and sepsis. Six of the patients were admitted to the Department of Pediatrics, Severance Hospital and Youngdong Severance Hospital in 1986 and one was admitted in 1979. The age of onset ranged from 10 to 34 days of age and all were cases of late onset. The Clinical findings were fever, seizure, poor feeding,...
Percutaneous Balloon Angioplasty in Patients with Congenital Aortic Valvular Stenosis.
Yong Soo Yun, Chang Yee Hong
Clin Exp Pediatr. 1988;31(7):817-821.   Published online July 31, 1988
Aortic valve stenosis was relieved by balloon dilatation during cardiac catheterization on 9 children aged 1 month to 15 years. Aortic valve diameter was estimated by two dimensional echocardiography to assist in the choice of balloon size. Before dilatation the transaortic systolic pressure gradients ranged from 60 mmHg to 177 mmHg, (mean: 91 ±38 mmHg). There were signifeant reduction in the transaortic systolic pressure...
Hypoplastic Left Heart Syndrome : Report of a Unique Survivor.
Hang Bo Cho, Seong Ho Kim, Ha Baik Lee, Kyu Hwang Rhee, Chong Moo Park
Clin Exp Pediatr. 1988;31(6):790-795.   Published online June 30, 1988
Hypoplastic left heart syndrome is a rare, and fatal congenital heart disease. Most of the patients with this syndrome die within the 1st month of life. Recently we experienced a hypoplastic left heart syndrome in a child who was unusually living without surgical intervention for 3 and half years. The unique clinical course might result from a number of favorable hemodynamic factors and intact...
Truncus Arteriosus Associated with Interrupted Aortic Arch.
Chang Hyun Yang, Jae Seung Yang, Jun Hee Sul, Dong Soo Kim, Sung Kyu Lee, Dong Shik Chin
Clin Exp Pediatr. 1988;31(6):779-783.   Published online June 30, 1988
We experienced a case of truncus arteriousus associated with interrupted aortic arch, ventricular septal defect and patent ductus arteriosus. A 5 month old boy had complained of rapid respiration and feeding difficulty since birth. There was no visible cyanosis or clubbing toes and nails. There was a grade 2 〜3 ejection systolic murmur with maximum intensity at the left lower sternal border. Diagnosis was...
Statistical Analysis of Pediatric Diseases in Korea.
Kyong Su Lee, Ki Sup Chung, Ki Yang Ryoo, Woo gill Lee, Sang Bum Lee, Se Jin Kang
Clin Exp Pediatr. 1988;31(6):678-690.   Published online June 30, 1988
Statistical analysis of pediatric diseases in patients admitted to the department of pediatrics in 34 hospitals having pediatric residency program for 2 years from Jan. 1985 to Dec. 1986 was underwent for the purpose of assessing the disease pattern in the pediatric aged people in Korea. The results obtained were as follows 1) Total number of inpatients was 112,309, of which 69,266 were male and...
A Case of Congenital Nephrotic Syndrome.
Choong Sun Kang, Chang Hee Hwang, Pyung Kil Kim, Hyeon Joo Jeong, In Joon Choi, Jung Hye Choi
Clin Exp Pediatr. 1988;31(5):627-634.   Published online May 31, 1988
Congenital nephrotic syndrome is an uncommon disorder, which is caused by a heterogenous group of renal diseases with variable etiology and natural history. It may be inherited, sporadic, acquird or a part of a general malformation syndrome. This disorder has no single or pathological feature for pathognomonic finding, and there is no ultimate curative treatment except renal transplantation. We experienced a case of congenital...
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