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Original Article
Therapeutic Effect of Different Doses of Recombinant Human Granulocyte Colony-Stimulating Factor(rhG-CSF) on Neonatal Sepsis Complicated by Neutropenia
Moon Young Choi, Yeon Sook Jung, Dong Woo Son, Hyo Seop Ahn
Clin Exp Pediatr. 2002;45(4):439-448.   Published online April 15, 2002
Purpose : The aim of this study is to determine and compare the effects of adjunctive therapy with different doses of recombinant human granulocyte-colony stimulating factor(rhG-CSF) on reversing sepsis-associated neonatal neutropenia, and their survival rate in a group I/II-type trial. Methods : RhG-CSF was injected subcutaneously to 10 septic-neutropenic neonates with doses of 10 μg/kg from Oct. 1995 to Sep. 1996,...
Short Term Effect of Recombinant Human Growth Hormone Therapy in Children with Chronic Renal Failure
Si-Whan Ko, Dong-Kyu Ji
Clin Exp Pediatr. 1998;41(9):1256-1261.   Published online September 15, 1998
Purpose : Growth retardation is one of the major side effects of chronic renal failure. In this study, the short-term growth promoting effect, effect on the chemical parameters, and probable side effects of growth hormone treatment to child patients with chronic renal failure were examined. Methods : The research sample was 5 child patients diagnosed with chronic renal failure and receiving...
Case Report
Protein Losing Entropathy Due to TB Enterocolitis was Detected by 99mTc-Human Serum Albumin Scan
Hyoung No Kim, Jae Won Huh, Sang Gun Bee, Yong Woon Back, Chang Hyun Lee
Clin Exp Pediatr. 1997;40(12):1750-1755.   Published online December 15, 1997
Protein losing entropathy was a secondary disorder of the gastrointestinal tract, which is associated with lymphatic obstruction, inflammatory and noninflammatroy disease. It' s clinical manifestations were abdominal pain, edema, diarrhea and growth failure. We described a 12-year-old boy, who had chronic diarrhea for 3 months and edema of lower extremities for 7 days. He also had severe hypoalbuminemia, iron definency anemia, liver diseases and malnurition,...
Original Article
Prophylactic Treatment of Anemia of Prematurity with Recombinant Human Erythropoietin and High Doses of Iron
Young Ho Lee, Ahn Hong Choi, Soon Yong Lee, Jeong Sook Park, Bong Keun Choi, Hyoung Shim Chang
Clin Exp Pediatr. 1997;40(3):361-367.   Published online March 15, 1997
Purpose : We conducted randomized study to determine whether high doses(6mg/kg/ day) of iron would exert a more supplemental effect than low doses(3mg/kg/day), and which regimen of recombinant human erythropoietin(rHuEPO) and iron would be more beneficial in the prophylactic treatment of anemia of prematurity. Methods : We randomly assigned 38 sick premature infants who were more likely than symptom-free premature infants requiring erythrocyte transfusions for...
Effect of Recombinant Human Erythropoietin on the Anemia of Premature Infants
Young Ah Lee, Ki Soo Kim, Young Seo Park, Hyung Nam Moon, Chang Yee Hong
Clin Exp Pediatr. 1996;39(5):631-640.   Published online May 15, 1996
Purpose : To determine whether the prophylactic treatment with recombinant human erythropoietin(rHuEPO) for the anemia of prematurity would reduce the need for blood transfusions. Methods : We randomly assigned 17 premature infants to therHuEPO group and the control group. For the rHuEPO group (n=9, birth weight=1210¡¾156 g, gestational age=31.7¡¾1.9wk), rHuEPO (400U/kg) was given three times a week for 4 weeks, plus iron (8 mg/kg/day) and vitamin...
A Study of Relation between Serum Aminotransferase Elevation and Clinical Symptoms from Human Rotavirus Gastroenteritis
Gee Sun Hong, Hwa Young Jeon, Won Kyu Choi, Mee Kyung Namgoong, Jong Soo Kim
Clin Exp Pediatr. 1995;38(1):54-60.   Published online January 15, 1995
This study was taken to measure the serum aminotransferase level and it's correlation with clinical symptoms from Human Rotavirus gastroenteritis. This report is based on analysis of 434 patients who were admitted to the Pediatric department at Wonju Christian Hospital because of watery diarrhea and vomiting during 2-year period from July, 1991 to June 1993. The stool specimen on admission...
A Study of Serum Transaminase Level and It's Correlation with Several Symptoms in Children with HRV Gastroenteritis
Gang Youl Bae, Eui Tak Oh, Woo Sik Jung, Kil Seo Kim
Clin Exp Pediatr. 1993;36(8):1146-1155.   Published online August 15, 1993
The retrospective study was taken to study the serum trasnsaminase level and it's correlation with several symptoms in human rotavirus gastroenteritis. 494 children, who admitted to the Department of Pediatrics in Dae Dong Hospital from January 1991 to December 1991 with chief complaints of waterdy diarrhea were included in studies. The 1 st stool specimen on admission was tested for rotavirus Ag...
Growth Promoting Effect of Recombinant methionyl-Growth Hormone in Children with Chronic Renal Failure
Heon Seok Han, Yong Choi, Hyung Ro Moon
Clin Exp Pediatr. 1992;35(10):1355-1360.   Published online October 15, 1992
The authors studied the growth-promoting effect of yeast-derived methionyl-hGH in short statured children with uremic chronic renal failure. The subjects were prepubertal chronic renal insufficient patients whose height standard deviation scores were below -2.0. Two boys and two girls participated in this study. Chronic renal insufficiency was the only cause for the short stature. HGH was given to the subjects in dose...
Clincal Observations on Human Rotavirus (HRV) Gastroenteritis
Seung Ryong Han, Seung Hyun Seo, Ki Sik Min, Jong Wan Kim, Kwang Nam Kim, Ki Yang Ryoo
Clin Exp Pediatr. 1992;35(2):226-233.   Published online February 15, 1992
Clinical observations were made on 787 patients who were admitted to pediatric department of Kangdong Sacred Heart hospital because of watery diarrhea and vomiting between Jan. 1987 and Dec, 1989. ELISA study was done to detect HRV antigen for all patients. The results were as follows : 1) HRV antigen was detected in 492 patients (62.5%) by ELISA among 787 patients with watery...
Effect of yeast-derived methionyl recombinant growth hormone on growth hormone deficient dwarf.
Jong Jin Seo
Clin Exp Pediatr. 1991;34(9):1269-1275.   Published online September 30, 1991
Fifteen GH deficient dwarfs were treated with LBD-003, the first year-derived rhGH produced in Korea. The growth promoting effect of LBD-003 was excellent and similar to that of the pituitary extract GH or the previous imported rhGHs. The serum concentrations of IGF-1 at 6th and 12th month of treatment showed significant elevation (p< 0.005, p< 0.001 respectively), but no significant correlation was observed between the...
Study on the antibody formation in patinets treated with recombinant human growth hormone(rhGH).
Hye Jung Joo, Duk Hi Kim, Dong Soo Kim
Clin Exp Pediatr. 1991;34(9):1261-1268.   Published online September 30, 1991
Patients with short stature admitted to the Pediatrics Endocrinology Clinic, Yonsei University College of Medicine during a six-year period from August, 1983 to August, 1989 were divided into three groups. The group 1 received rhGH, group 2 received Oxandrolone and group 3 did not receive any treatment. These patients were tested for presence of antibodies to rhGH with ELISA and effect of rhGH was evaluated. 1) Among 53...
Production and characterization of monoclonal antibodies against human albumin.
Ja Wook Koo, Dong Kyu Jin, Yong Choi, Kwang Wook Ko, Suhnggwon Kim, Jung Sang Lee, Chung Gyu Park, Chang Yong Cha
Clin Exp Pediatr. 1991;34(8):1070-1079.   Published online August 31, 1991
Hybridoma technology를 이용하여 human albumin에 선택적으로 반응하는 4 종류의 단세포군 항 처 1(HSA-1，HSA-2, HSA-3, HSA-4) 를 개발하였다. 단세포군의 isotype 및 subclass를 효소 결합 면역 측정법으로 검색한 결과 IgGi 이었다. 단세포군 항체 HSA-1 을 제외한 HSA-2, HSA-3, HSA-4 모두 human albumin에 선택적으로 반 응함을 효소 결합면역 측정 법과 Western blot immunoassay로 알아내 었다. HSA-1, HSA-2, HSA-3는 albumin의 reduction 여부와 관계 없이 albumin molecule과 반응하였 으나，HSA-4는 albumin을 reduction하지...
The effects of human growth hormone on short stature.
Sang Mi Ha, Duk Hi Kim
Clin Exp Pediatr. 1991;34(7):999-1008.   Published online July 31, 1991
Since Raben’s original report that human growth hormone promoted growth in a boy with pituitary dwarfism, the hormone’s efficacy in children with growth hormone deficiency has been amply confirmed. However the scarcity of growth hormone prepared human pituitaries has limited studies of its usefulness in short stature. The availability of a biologically active human growth hormone produced by recombinant-DNA technology has dramatically changed the...
A Study of Serum Transaminase Level and It's Correlation with Dehydration in Children with HRV Gastroenteritis.
Tae Joon Park, Eung Sang Choi
Clin Exp Pediatr. 1990;33(12):1662-1669.   Published online December 31, 1990
The study was taken to study the serum transaminase level and it’s correlation with dehydration in Human Rotavirus gastroenteritis. 129 children, who admitted to the Department of Pediatrics in Chung-Ang University Hospital from January 1987 to December 1989 with chief complaints of fever, vomiting, and watery diarrhea were included in this studies. The stool specimen on admission was tested for Rotavirus Ag by ELISA method....
Human Rotavirus Antigen in Respiratory Secretion.
Kyung Min Lee, Won Chul Lee, Kook Shin Chang, Mee Kyung Chjang, Woo Tack Kim, Dong Jin Lee
Clin Exp Pediatr. 1990;33(9):1223-1230.   Published online September 30, 1990
A clinical study was carried out on 33 diarrhea patients to determine the frequency and degree of respiratory symptoms and signs in patients with gastroenteritis who had HRV antigen in respira- tory secretion. We devided study group into two: One was 11 children who had HRV antigen in respiratory secretion but did not have in diarrheal stool and the other was 22 children who...
The Pharmacokinetics, Acute Biological Effects and Safety of Recombinant Human Growth Hormones.
Jong Jin Seo
Clin Exp Pediatr. 1990;33(8):1104-1110.   Published online August 31, 1990
The pharmacokinetics, acute biological성fccts and safety of yeast-derived recombinant methionyl- hGH (LBD-003), the first biosynthetic hGH in Korea, were studied in 10 healthy young adults who were administered 8 IU/day intramuscularly for four consecutive days. 1) GH levels reached a mean (±SD) peak of 27.5±10.7 ng/ml at 3.4±0.8 hours following the first dose, and other pharmacokinetic parameters of LBD-003 were similar to those reported for pituitary...
Asymptomatic human rotavirus infections during infancy and preschool period.
Hye Lim Jung, Byoung Hoon Yoo, Tae Sub Shim
Clin Exp Pediatr. 1989;32(11):1482-1488.   Published online November 30, 1989
Asymptomatic human rotavirus (HRV) infection rate was studied by comparing the rate of HRV excretion in diarrhea cases with that in nondiarhea group of children under preschool age. HRV antigen in stool was detected by enzyme-linked immunosorbent assay (ELISA) from children under 6 years of age who were admitted to Pediatric Department of Chung-Ang University Medical Center from November 1988 to mid-April 1989. 1) HRV antigen...
Clinical Studies of Human Rotavirus Gastroenteritis.
Eun Ok Rhee, Nam Joo Hwang, Yaung Sook Choi, Son Sang Seo
Clin Exp Pediatr. 1989;32(10):1369-1376.   Published online October 31, 1989
A clinical study of 92 HRV Antigen positive patients among 270 children admitted to the pediatric department of II Sin Christian Hospital because of diarrhea between Sept. 1st 1986 and Aug. 31st 1987 is reported. All cases were detected by the ELISA method. 1) All patients were under 2 year of age with the peak incidence being between 6 month and 1 year of age and...
A Case of Human Tail.
Kon Hee Lee, Ok Ji Hwang, Ha Joo Choi, Woo Kap Chung
Clin Exp Pediatr. 1989;32(2):285-288.   Published online February 28, 1989
The human tail is thought to be a rare congenital anomaly which resulted from persistence of the vestigial tail of the 14 -16 mm. human embryo. A child with a tail causes for the parents and, in some cases, a feeling of stigma and shame. We experienced a case of human tail who was an 1-day old male. Examination of the baby revealed a...
Clinical Observation of Human Rota Virus(HRV) Gastroenteritis.
Kee Don Hong, Gil Hyun Kim, Jae Ock Park, Sang Jhoo Lee
Clin Exp Pediatr. 1988;31(6):700-706.   Published online June 30, 1988
This study was done with the 96 patients with watery diarrhea from Oct. to Nov. 1986. ELISA study was done to detect Human Rota Virus antigen for all patients. Clinical and laboratory comparision were made between HRV antigen positive group and HRV antigen negative group. The results were as follows: 1) HRV antigen was detected in 62 patients (64.6%) among 96 patients of diarrhea or...
The Influence of Breast Feeding on Clinical Course in HRV Gastroenteritis.
S K Lee, H S Kim, C M Kang
Clin Exp Pediatr. 1987;30(2):144-149.   Published online February 28, 1987
A total of 183 infants under the age of one year which were diagnosed as having HRV gastroenteritis at Pediatric Department, Keimyung University, Dong San Medical Center were studied to determine whether breast feeding can influence the incidence and the clinical course of the disease during the first year of life. Among 183 infants, 62 were breast-fed, 77 were formula-fed, and 44 were...
Clinical Observation on Human Rota Virus Gastroenteritis in Infants and Children.
Han Young Jeong, Gu Seok Jung, Sung Won Kim, Kyung Tae Kim, Kil Hyun Kim
Clin Exp Pediatr. 1986;29(5):517-524.   Published online May 31, 1986
The author studied 105 cases of HRV antigen positive detected by ELISA method among 325 children admitted to the pediatric ward at St. Benedict hospital, whose chief complain was diarrhea during the period of 1 year from Dec. 1st 1983 to Nov. 30, 1984. The results were as follow: 1) A high incidence of antigen positive was observed among...
Study on HRV Gastroenteritis and Nosocomial Infection.
W P Chung, T W Paik, C M Kang
Clin Exp Pediatr. 1986;29(4):394-400.   Published online April 30, 1986
The study was carried out on 227 diarrhea patients to determine the etiology and epidemiology and on 18 patients who developed diarrhea 72 hours following admission to determine the nosocomial acquisition of HRV. The HRV antigen was determined by ELISA. The HRV antigen study was also done on 21 pediatric house staffs and nurses who were taking care of these patients...
Zinc and Copper Concentrations in Human Milk.
Hwa Young Kim, Hyun Young Ahn, Young Yoon Choi, Tae Ju Hwang, Chull Sohn
Clin Exp Pediatr. 1985;28(4):305-313.   Published online April 30, 1985
Human milk is the most appropriate of all available milks for the human infant since it is uniquely adapted to his or her needs. Zinc and Copper are essential for not only as the constituents of enzymes and their activators, but also growth, development and normal metabolism. Zn and Cu concentrations were observed according to the stage of lactation, parity,...
Clinical, epidemiological, and serological observation on human rotavirus gastroenteritis in infants and children.
Chin Moo Kang
Clin Exp Pediatr. 1985;28(2):140-146.   Published online February 28, 1985
The author studied 115 infants with watery diarrhea, admitted to the Pediatric Department of Dorg San Medical Center during the period of 9 months from October 1982 through June 1983 and dsveloped an Enzyme lirked immunosorbent assay to detect human rota virus antigen for all patients and clinical, epidemiologic, and laboratory studies were done. The results were as follows: 1)76...
Clinical, Laboratory and Epidermiology Feature of Human Rota Virus(HRV) Gastroenteritis.
Bok Hee Oh, Soo Jee Moon, Keun Soo Lee
Clin Exp Pediatr. 1983;26(10):959-966.   Published online October 31, 1983
According to the statistical survey for hospitalized children with acute diarrheal diseases, we have experienced big incidence of acute epidemic gastroenteritis during the months of October and November every year. In order to investigate the nature of such epidemic gastroenteritis 24 inpatients with acute gastroenteritis were selected at random for electron microscopic(E.M.) examination of stool as well as enzyme linked immunosorbent assay...
Developmental Changes of Membrane Proteins from Human Erythrocytes.
Chan Uhng Joo, Hyun Suk Lee, Jung Soo Kim, Kyu Cha Kim, Hyung Rho Kim
Clin Exp Pediatr. 1982;25(6):541-546.   Published online June 30, 1982
To investigate the developmental changes of human erythrocytes, adult and fetal erythrocyte membranes prepared from adult and cord blood were analyzed in regard to their proteins, glycoproteins, enzyme activities and glucose transport systems. 1. Adult and fetal erythrocyte membranes appeared to have the same major proteins and gl-ycoproteins in the electrophoretic pattern. 2. ATPase activity in adult erythrocyte membranes was...
Changes in Na and K Concentrations in Human Milk: at different stage of lactation.
Byung Ryong Lee, Jae Sook Ma, Chull Sohn
Clin Exp Pediatr. 1982;25(1):1-7.   Published online January 31, 1982
The concentrations of Sodium and Potassium were measured by flame photometer in the human for milk obtained at clostral(1st 5days postpartum), early transitional (2nd 5days postpartum), late transitional (11th to 29th day postpartum) and mature milk period (1to 15 months postportum) from 92 healthy nursing mothers who delivered at term. The results were summerized as follows: 1) The concentrations of...
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