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Original Article

Assessing kidney outcomes in childhood-onset lupus nephritis: role of National Institutes of Health-modified histological indices

Nuanpan Penboon, Pornpimol Rianthavorn

Background: Childhood-onset lupus nephritis (cLN) is an aggressive disease. Although histological class has historically guided its treatment, its prognostic value remains limited. Although the National Institutes of Health (NIH)-modified activity index (AI) and chronicity index (CI) incorporate glomerular and tubulointerstitial changes and may provide better prognostic insight, their utility in cLN is not well established.
Purpose: Here we aimed to assess the utility of the NIH-modified-modified AI and CI...

DOI: https://doi.org/10.3345/cep.2025.01277 [Accepted]

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