Clinical and Experimental Pediatrics

Original Article

The Protective Effect of Vitamin E and Desferrioxamine on Cultured Cerebral Neurons of Neonatal Mouse Damaged by Ischemic Condition

So-ra Lee, Yeon-kyun Oh, Seung-taek Park

Clin Exp Pediatr. 1999;42(10):1426-1433. Published online October 15, 1999

Purpose : Perinatal asphyxia is an important cause of neurologic morbidity. Experiments in animal models of hypoxic-ischemic brain injury demonstrate that brain damage starts during hypoxia-ischemia. In order to evaluate the ischemic condition-induced neurotoxic effect in view of oxi- dative stress, we examined the cytotoxic effect in cultured cerebral neurons of neonatal mouse. Methods : Dissociated cell cultures were prepared...

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The Effects of Glutamate Receptor Antagonists on Cultured Cerebral Cortical Neurons of Neonatal Mouse Damaged by Oxidative Stress

Dae-ho Choi, Yeon-kyun Oh, Seung-taek Park

Clin Exp Pediatr. 1999;42(8):1096-1103. Published online August 15, 1999

Purpose : To evaluate neurotoxic effects induced by oxygen-radicals, which were generated by adding xanthine oxidase(XO) and hypoxanthine(HX), and protective effects of glutamate receptor antagonist such as MK-801 and 6-cyano-7-nitroquinoxaline(CNQX). Methods : Dissociated cell cultures were prepared from cerebrum of neonatal mouse. Tissues were dissected and diced into small pieces in phosphate buffered saline and were incubated at 37℃. Isolated cells...

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Effect of Oxygen Radicals on Cultured Cerebral Neurons of Neonatal Mouse

Yeon-kyun Oh, Seung-taek Park

Clin Exp Pediatr. 1997;40(6):786-793. Published online June 15, 1997

Purpose : In order to elucidate the neurotoxic mechanism of oxygen radicals which are pathological factor of ischemia, we evaluated the oxidant-induced neurotoxicity and the neuroprotective effect of antioxidant on cultured cerebral neurons derived from neonatal mouse. Methods : Neurotoxic effect was investigated after cultured mouse neuronal cells were exposed to oxygen radicals which were generated enzymatically by reaction of xanthine oxidase(XO) and hypoxanthine(HX). And also...

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