Clinical and Experimental Pediatrics

Original Article

A Follow-Up Study of Intractable Diarrhea in Early Infancy: Clinical Features of Cow's Milk Allergy and Cow Milk-Sensitive Enteropathy

Young Rak Kwon, Young Ho Ahn, Jin Bok Hwang, Chang Ho Han, Hai Lee Chung, Young Dae Kwon

Clin Exp Pediatr. 1995;38(11):1515-1524. Published online November 15, 1995

Purpose : The multiplicity of poorly defined illnesses and the variability of clinical and laboratory features elicited by milk ingestion in sensitized infants has made it difficult to differentiate them from the more common forms of cow milk intolerance. Following up the cases of intractable diarrhea in early infancy(illI), We investigated the clinical features of cow's milk allergy(CMA) and cow...

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A Clinical Study on the Liver Cirrhosis in Children: Review of 40 Cases

Je Woo Kim, Ki Sup Chung, Chan Il Park

Clin Exp Pediatr. 1995;38(11):1506-1514. Published online November 15, 1995

Purpose : Liver cirrhosis is relatively uncommon disease in childhood, but the overall prevalence rate and etiology of the liver cirrhosis in children were uncertain in Korea. This clinical study was undertaken to help pediatricians manage the patients properly by investigating the etiology, clinical findings and the outcome on 40 pediatric patients with liver cirrhosis. Methods : This study was conducted...

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A Clinical Evaluation of the Gastrofiberscopy Studies in Children

Jung Ah Park, Young Ho Ahn, Jin Bok Hwang, Chang Ho Han, Hai Lee Chung, Young Dae Kwon, Jae Bok Park

Clin Exp Pediatr. 1995;38(11):1498-1505. Published online November 15, 1995

Purpose : This study aimed to provide, as basic material, the experience of gastrofiberscopy in children and the clinical significance of Helicobacter pylori(H. pylori) infection in pediatric gastrointestinal disease. Methods : The objects were 99 patients(male 49, female 50) who underwent gastrofiberscopic examination in case of endoscopic indication at department of pediatrics of Taegu Hyosung Catholic University Hospital from March 1993...

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Respiratory Syncytial Virus Infections and Application of Nested Reverse Transcription-Polymerase Chain Reaction

Kon-Hee Lee, Hae-Sun Yoon, Kyu-Man Lee, Kyung-Hee Kim, Yang-Ja Cho

Clin Exp Pediatr. 1995;38(11):1486-1497. Published online November 15, 1995

Purpose : Respiratory syncytial virus(RSV) in the most common cause of bronchiolitis and pneumonia in chileren less than 2 years old. Complications of RSV infections may be life-threatening in children who are immunosuppressed or who have congenital heart disease. Thus it is imperative that laboratory results be rapid and accurate. We therefore were interested in evaluating the role of RSV...

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Concentrations and Placenta Transferability of Subclasses of IgG in Newborn Infants with Gestational Age

Gyung Hee Kim

Clin Exp Pediatr. 1995;38(11):1476-1485. Published online November 15, 1995

Purpose : The object of this study was to investigate concentration and placental transfer of IgG subclasses in greater detail and examine the effect of gestational age. Methods : The concentration of IgGl. IgGz. IgG3 and IgG4 were estimated in 119 pairs of maternal and cord sera from pregnancies of various gestation ranging from 32 to 43 weeks using the method...

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Use of Fluorescent in Situ Hybridization to Evaluate the Number of Chromosomes in Buccal Smear Cells in Normal Newborn Infants

Byoung Chan Lee, Jee Yeon Song, So Young Kim, Hyun Hee Kim, Seunghoon Han, Jong-In Byun, Wonbae Lee, Kyong Su Lee

Clin Exp Pediatr. 1995;38(11):1470-1475. Published online November 15, 1995

Purpose : The diagnosis for chromosomal anomality has been made by obtaining cells in metaphase from peripheral blood and fresh tissue culture. But this method is difficult to perform because somewhat invasive and necessary time for cell culture and staining(48-72hr). Recently, the method to find numerical abnormalities in, autosome and sex chromosome of adult buccal mucosal smear by FISH was...

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Clinical Characteristics of Patients with Tumer' Syndrome according to Karyotypic Differences

Eun Young Kim, Kyoung Sim Kim, Kibok Kim, Won Jin Kee

Clin Exp Pediatr. 1995;38(11):1460-1469. Published online November 15, 1995

Purpose : To assess the differences of clinical features according to various karyotypes in Turner syndrome. Methods : Subjected to study were 45 patients with Turner syndrome, including 5 newborns, from March 1974 to April 1994. They were divided into 3 groups according to karyotypes: 45,X, mosaicism, and structural aberration; and the clinical features were compared. Also structural aberration groups, 46,XXp-and...

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The Correlation between the Duration of Breast Feeding and Iron Deficiency Anemia(IDA)

Yee Ja Kang, Ha Sin Park, Hae Jin Choeh, Kyuchul Choeh

Clin Exp Pediatr. 1995;38(11):1453-1459. Published online November 15, 1995

Purpose : Iron deficiency anemia(IDA) is the most common nutritional deficiency. in young infants. This study was designed to determine a correlation between the duration of breast feeding and the severity of IDA, and to determine the recommending start point of iron fortified diet. Methods : The correlation between duration of breast feeding, and severity of iron deficiency. and IDA was...

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The Changes of Thyroid Function Tests and TSH Receptor Antibody Levels During Antithyroid Drug Therapy of Graves Disease in Children

Jeong-Ho Kim, Eun-Young Cho, Han-Wook Yoo

Clin Exp Pediatr. 1995;38(10):1404-1410. Published online October 15, 1995

The mainstay of treatment in children with Graves' disease is antithyroid drug therapy. Most commonly used drugs are methimazole(MMI) and propylthiuracil(PTU). These drugs inhibit thyroid hormone synthesis through mechanisms that interfere with the action of thyroid peroxidase. Since antithyroid drugs are unable to inhigit the secretion of thyroid hormone which is already produced, it takes 2 to 3 weeks for...

Relationship of Insulin-like Growth Factor-I with Pharmacologically Stimulated Growth Hormone secretion in Growth hormone Deficient Children

Phil-Soo Oh, Ki-Joong Kim, Young-Iee Yu, In-Joon Seol, Jeh-Hoon Shin

Clin Exp Pediatr. 1995;38(10):1394-1403. Published online October 15, 1995

Purpose : At present, to determine growth hormone(GH) deficiency in short stature, many provocative tests using various pharmacologic agents such as clonodine, L-dopa, insulin should be done. These are not only complicated, but also misleading in some patients. And so, in search of a simple method of detecting GH deficiency that may replace the complicated stimulation test, we measured basal...

Effect of Prophylactic Treatment of High Doses Recombinant Human Erythropoietin on Anemia in Premature Infants

Soon Seong Park, Seong Ho Hong, Hye Lime Jung, Dong Hyeok Keum

Clin Exp Pediatr. 1995;38(10):1384-1393. Published online October 15, 1995

Purpose : This study was conducted to determine whether prophylatic treatment with recombinant human erythropoietin(rHuEPO) could prevent anemia and reduce the need for blood transfusion in premature infants. Methods : This study was conducted from May, 1992 to July 1994. We randomly assigned 24 premature infants with gestational age less than 34 weeks and birth weight less than 2.0kg. After having...

Prospective, Controlled Trial with Dipheny1-dimethy1-dicarboxylate in Children with Chronic Liver Diseses : The Effect on Lowering Serum Aminotransferase Levels

Ji Eun Wunon, Sang Gil An, Ki Moon Cha, Yong Min Chung, Hee Sup Kim, Hann Tchah, Ho Jin Park

Clin Exp Pediatr. 1995;38(10):1378-1383. Published online October 15, 1995

Purpose : The prospective cotrolled study was performed to identify the effect of the dipheny1-dimethy1-dicarboxylate(PMC) on lowering serum transaminases in children with chronic liver diseases. Methods : The twenty patients were paticipated in this study who were followed up in the Department of Pediatrics of the Seoul Red Cross Hospital because of the elevated levels of serum alaine aminotransferase(ALT) and aspartate...

Etretinate Induced Cardiovascular Malformations in Mouse Embryo

Il Kyung Kim, Chang Sung Son, Young Chang Dockgo, Yong Hyuk Jeon

Clin Exp Pediatr. 1995;38(10):1370-1377. Published online October 15, 1995

Purpose : Etretinate(Tigason? is an aromatic retinoid currently in therapeutic use for psoriasis but studies have shown that it is a potent teratogen in human and in experimental animal. So we carried this study to observe teratogenic effects of etretinate and to search a possibility of etretinate for using as an experimental model to induce cardiovascular malformation. Methods : In order...

Change of Coronary Arterial Distensibility by Intravenous Infusion of Adenosine in Kawasaki Disease Patients Who Had Coronary Artery Aneurysm

Myung Chul Hyun

Clin Exp Pediatr. 1995;38(10):1363-1369. Published online October 15, 1995

Purpose : To investigate the effect of Kawasaki disease on coronary arterial distensibility, we studied 14 patients with Kawasaki disease who had had coronary artery aneurysms(mean of 4.5years have elapsed after onset of Kawasaki disease). Methods : Using Hewiett Packard-1500 echocardiogram, we measured RR interval, BP(blood pressure), EDD(end diastolic dimension), ESD(end systolic dimension), FS(fractional shortening), LVPWT(left ventricular posterior wall thickness), peak...

A Clinical Study of Interrupted Aortic Arch

Myoung Dong Shin, Tae Hun Kang, Hyoung Doo Lee, Si Chan Sung

Clin Exp Pediatr. 1995;38(10):1349-1355. Published online October 15, 1995

Purpose : We conducted this study to determine the clinical manifestations and prognostic factors of interrupted aortic arch(IAA). Methods : We performed retrospective clinical study with chart review in 9 infants who were diagnosed as IAA between January, 1993 and December, 1994. Results : Infants with IA were from 7 days to 92 days of age. Among them, 6 cases were type...

Cough Variant Asthma

Bin Cho, Joon Sung Lee

Clin Exp Pediatr. 1995;38(10):1340-1348. Published online October 15, 1995

Purpose : Asthma, one of the most common of chronic cough in children, is easily diagnosed when classic triad; cough, wheezing, dyspnea are presented. However, it has become apparant that cough may be the sole manifestation of this disease. This cough variant asthma is underdiagnosed and undertreated. The clinical manifestations and subject variables of asthma especially, cough variant asthma had...

A Study of Antimicrobial Sensitivity to Isolated Bacteria in Ulsan

Sun Ju Kim, Yong Woon Baek, Jin Yeong Jeong, Sung Ryul Kim

Clin Exp Pediatr. 1995;38(10):1329-1339. Published online October 15, 1995

Purpose : The Patterns of predominant microorganisms and their antibiotic sensitivity have been changed by various factors. Identification and evaluation of major pathogenic organisms and selection of optimal antibiotics were essential in the management of infectious diseases. This susceptibility patterns of antibiotics would be useful to improve empirical antimicrobial therapy. Methods : We studied the antimicrobial sensitibity to isolated bacteria from...

Circumcision, Neonates, Pain sensation

In Rok Do, Jeong Ho Lee, Yong Sub Kim, Jong Dae Jo

Clin Exp Pediatr. 1995;38(10):1324-1328. Published online October 15, 1995

Purpose : Routine neonatal circumcision has widely performed without anesthesia under the assumption that the penis of neonates does not yet have functioning pain sensory nerve endings at this early stage of development, and has decreased the incidence of neonatal urinary tract infection. This study was performed to evaluate whether neonates recognize pain during opertion of circumcision without anesthasia. Methods :...

Analysis of Auditory Brainstem Response in the Infants at High Risk for Hearing Disability

Kang Ho Cho, Myoung Jae Chey

Clin Exp Pediatr. 1995;38(10):1315-1323. Published online October 15, 1995

Purpose : This study is performed to evaluate the clinical course, degree of hearing impairment and neurologic outcome of the infants at high risk for hearing disability. Methods : The 603 infants who had risk factors, such as severe birth asphyxia, hiperbilirubinemia requiring exchange transfusion, head and neck anomaly every low birthweight under 1500gm, family history of childhood hearing impairment, bacterial...

Changes of Serum Tumor Necrosis Factor-α and Interleukin-1β in the Sepsis of Neonates

Mi Yeon Lee, Yeon Kyun Oh, Ji Hyun Cho

Clin Exp Pediatr. 1995;38(10):1307-1314. Published online October 15, 1995

Purpose : Cytokines have recently been identified as important endogenous mediators of the host immune response to bacterial infection. But little is clarify about serum levels of cytokines in neonatal sepsis. The aim of this study was to know the changes of the level of cytokines during neonatal sepsis, to compare the level of cytokines in gram negative and gram...

Relation between Airway Responsiveness and Serum IgE in Children with History of Asthma, Allergic Rhinitis, and Atopic Dermatitis

Su- Jin Park, Ki-Hyun Chung, Wan-Seob Kim, Kang-Seo Park

Clin Exp Pediatr. 1995;38(9):1262-1269. Published online September 15, 1995

Purpose : Asthma is known to be related to serum IgE levels. But it is not ascertained whether there is a relation between serum IgE levels and airway hyperresponsiveness to methacholine challenge. For this reason we studied the relation between the serum IgE levels and airway hyperresponsiveness or responsiveness in regard to asthma, allergic rhinitis, and atopic dermatitis. Methods : The...

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Iron Deficiency Anemia in Infants

Woon Ja Chung, Kue Sook Kim, Mi Kyung Kim, Shin Na Kim

Clin Exp Pediatr. 1995;38(9):1253-1261. Published online September 15, 1995

Purpose : To study the incidence of iron deficiency anemia we conducted blood tests with questionnaire regrarding weaning status. We tried to figure out the relation between iron deficiency anemia and financial and educational levels of their parents. The purpose of this study is to emphasize the importance of screening for iron deficiency anemia at well baby clinic and educate mothers...

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Analysis of Radiologic Findings in Children with Urinary Tract Infection

Won Suk Kuk, Il Kyung Kim, Ho Seong, Chang Hee Choi

Clin Exp Pediatr. 1995;38(9):1242-1252. Published online September 15, 1995

Purpose : Because some patients with urinary tract infection (UTI) may combine vesicoureteral reflux and progress to reflux nephropathy, the early diagnosis and treatment of UTI are important. We have performed this study to recognize the meaning of the radiologic examination centering around technetium 99m- labelled dimercaptosuccinic acid renal scan(DMSA scan) in pediatric UTI patients. Methods : We have studied 55...

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Clinical and Histologic Changes in Children with Chronic Hepatitis B Virus Infection after Alpha Interferon Therapy

Kyung Mo Kim, Soo Jong Hong, Young Seo Park, Hyung Nam Moon, Chang Yee Hong, Joo Ryoung Huh

Clin Exp Pediatr. 1995;38(9):1232-1241. Published online September 15, 1995

Purpose : Several trials in children for chronic hepatitis B have shown the efficacy of alpha interferon in eliminating hepatitis B virus replication, accompanied by an improvement in the liver cell damage. But reports about the alpha interferon therapy are rare in Korean children and there is no report about histologic changes even with adult. So we tried to...

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Results of the Mechanical Valve Replacement in the Right Side of the Heart in Children

Hyeon Jin Park, Chung Il Noh, Ho Sung Kim, Jung Yun Choi, Yong Soo Yun, Yong Jin Kim

Clin Exp Pediatr. 1995;38(9):1220-1231. Published online September 15, 1995

Purpose : We performed this study in order to evaluate the outcome of the mechanical valve replacement in the right side of the heart in children. Methods : Retrospective analysis of the clinical records of 26 patients who had undergone a right sided valve replacement between October 1986 and September 1992 at Seoul National University Children뭩 Hospital. Results : Twenty six children...

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A Study of Relationship between Bronchial Hyperreactivity (BHR) and Atopic Findings in Mycoplasma pneumoniae Pneumonia

In Kyeong Seo, Weon Jeong Bae, Jae Ook Lee, Im Ju Kang

Clin Exp Pediatr. 1995;38(9):1210-1219. Published online September 15, 1995

Purpose : The respiratory infection due to Mycoplasma pneumoniae among school aged children and adolescents was recognized as an important cause of wheezing or BHR. This study was performed to evaluate relationship between BHR to Mch inhalation challenge and atopic findings in M. pneumoniae pneumonia. Methods : 61 patients with M. pneumoniae pneumonia who were admitted to the department of Pediatrics,...

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Natural Anti-PRP Antibody Levels to Haemophilus Influenzae Type b(Hib) and Changes of Antibody Levels after Three Doses of Vacination

Eun Sun Yoo, Eun Ae Park, Gyoung Hee Kim

Clin Exp Pediatr. 1995;38(9):1201-1209. Published online September 15, 1995

Purpose : The Haemophilus influenzae type b(Hib) was the most common cause of meningitis and invasive bacterial disease mainly in children 2 months to 5 years old in the United States. The conjugated Hib vaccines have recently been licensed by the US Food and Drug Administration for routine use in infants beginning at 2 months of age, and the Infectious...

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Clinical Observations of Transient Idiopathic Hypocalcemia

Jeong Nyun Kim, Mi Jung Park, Duk Hi Kim, Ho Sung Kim

Clin Exp Pediatr. 1995;38(9):1193-1200. Published online September 15, 1995

Purpose : In concern of diagnosis and treatment of transient idiopathic hypocalcemia, a major cause of infantile, we studied the onset of age, clinical characteristics, laboratory findings, and duration of treatment and recovery of transient idiopathic hypocalcemia. Methods : The author observed 19 infants with transient idiopathic hypocalcemia who had been admitted to Yonsei university hospital due to convulsion for 4...

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Riboflavin Status of Normal Newborn Infants and the Changes of Riboflavin During Phototherapy in Hyperbilirubinemic Newborn Newborn Infants

Eun Ae Park, Gyoung Hee Kim

Clin Exp Pediatr. 1995;38(9):1185-1192. Published online September 15, 1995

Purpose : Riboflavin is the most important water soluble vitamin in infant nutrition. Riboflavin is converts to flavin mononucleotide (FMN), Flavin adenine dinucleotide(FAD) and then, participiates in the metabolism of energy, protein cellular oxidation-reduction reactions as a cofactor of reactions. Also riboflavin, a light sensitive vitamin, has a maximum absorption spectrum at a wave length similar to that at which...

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Serum 2-microglobulin and Retinol Binding Protein and Urine 2-microglobulin and 1-microglobulin in Early Neonatal Period

Jong Duck Kim, Jae Kak Choi, Yong Hwoe Moon

Clin Exp Pediatr. 1995;38(9):1176-1184. Published online September 15, 1995

Purpose : For evaluation of usefulness of the serum .2-microglobulin(B2MG), retinol binding protein(RBP), urine 1-microglobulin(A1MG), and B2MG on neonatal renal function and renal tubular injuries, we detected and compared these values in 20 neonates. Methods : They were grouped into premature neonate, gestational age was 30-50 weeks(group Ⅰ), and full term neonate, gestational age was 38-40 weeks(group Ⅱ), The group Ⅱ...

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Original article