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Original Article
Microdeletion of Chromosome 7 in Williams Syndrome and Supravalvular Aortic Stenosis
Ho Sung Kim, Yoon Sung Kang, Kyung Hyo Kim, Young Mi Hong, Yong Soo Yun, Kwang Ho Lee
Clin Exp Pediatr. 1999;42(1):47-59.   Published online January 15, 1999
Purpose : Williams syndrome is characterized by supravalvular aortic stenosis, mental retardation and peculiar facial appearance. Its genetic etiology is considered to be a hemizygotic deletion in Chromosome 7q11.23, which includes the elastin gene. We examined the hemizygotic deletion of Chromosome 7q11.23 in 12 Korean Williams syndrome patients and 8 patients with isolated supravalvular aortic stenosis and performed deletion mapping...
Prospective Randomized Study Comparing L-epinephrine and Budesonide Aerosols in the Treatment of Moderate to Severe Croup
Bo Hwa Choi, Kwang Bog Song, Jung Yeon Shim, Soo-Jong Hong
Clin Exp Pediatr. 1999;42(1):40-46.   Published online January 15, 1999
Purpose : The aim of this prospective, randomized study was to evaluate the effects and adverse effects of nebulized L-epinephrine compared with nebulized budesonide in children with moderate to severe croup. Methods : Children were eligible for the study if their croup scores fell in the moderate to severe range(scores>4) in the AMC from May 1995 till May 1996. The patients...
Effects of Two Different Surfactants on RBC Membrane and Type Ⅱ Alveolar Epithelial Cell in Vitro
Eun Ae Park, Gyoung Hee Kim
Clin Exp Pediatr. 1999;42(1):32-39.   Published online January 15, 1999
Purpose : Respiratory distress syndrome(RDS) is a major cause of death in premature babies. For the treatment of RDS, various artificial pulmonary surfactants have been used. The incidence of pulmonary hemorrhage is increased in association with surfactant therapy in extremely low birth weight infants. But the pathogenesis of this increased incidence is not clear. So we conducted this study...
A Nationwide Clinical Study of Acute Respiratory Distress Syndrome in Children
Soo Jung Choi, Do Suck Jeong, Jae Won Oh, Ha Baik Lee, Im Ju Kang, Kwang Woo Kim, Kyu Earn Kim, Ki Bok Kim, Young Ho Rah, Kang Seo Park, Byong Kwan Son, Ki Young Lee, Sang Il Lee, Ji Tai Choung, Young Mi Hong
Clin Exp Pediatr. 1999;42(1):23-31.   Published online January 15, 1999
Purpose : Acute respiratory distress syndrome(ARDS) is the final course of acute lung injury. It results from various etiological origins and pathophysiologic mechanisms, and has a mortality rate of approximately 60-70%. Although the confirmative incidence of ARDS in children is yet unknown, the increasing incidence of ARDS has been reported in Korea. In the present study, we report ARDS diagnosed...
Inhibitory Effects of Actinomycin-D and Pentoxifylline on the Production of IL-1α and TNF-α by Human Cord and Adult Blood Mononuclear Cells
Eun Ae Park, Kyung Hyo Kim, Gyoung Hee Kim
Clin Exp Pediatr. 1998;41(12):1700-1708.   Published online December 15, 1998
Purpose : An area of intense intrest is assessment of new therapeutic modalities that regulate the inflammatory response in acute bacterial infection is proving to be an area of interest these days. So we conducted this study to compare the inhibitory effects of actinomycin-D and pentoxifylline on the production of IL-lα and TNF-α from cord blood mononuclear cells(MC) to those...
Longterm Follow-up of Autosomal Recessive Polycystic Kidney Disease
June Huh, Il Soo Ha, Hae Il Cheong, Jeong Kee Seo, Yong Choi
Clin Exp Pediatr. 1998;41(12):1693-1699.   Published online December 15, 1998
Purpose : This study was aimed to assess the clinical manifestations and courses of autosomal recessive polycystic kidney disease(ARPKD). Methods : The medical records of 10 children diagnosed as infantile or juvenile ARPKD at Seoul National University Children's Hospital between January, 1984 and December, 1996, were reviewed, retrospectively. Results : The average age at diagnosis was 3 8/12 years(4months-7 3/12 years)...
The Effect of Low-Dose Dopamine on the Renal Function of Asphyxiated Neonates
Seung Yeon Nam, Eun Ae Par, Seung Joo Lee
Clin Exp Pediatr. 1998;41(12):1685-1692.   Published online December 15, 1998
Purpose : Low-dose dopamine(0.5-3μg/kg/min) increases renal blood flow, glomerular filtration rate and natriuresis and has protective and therapeutic effects on oliguric renal failures. Asphyxia is the most common cause of acute renal failure in neonates. But the protective effects of dopamine have never been reported in asphyxiated neonates. So we reported the effects of low-dose dopamine on the renal function...
Long-term Follow-up Study of Children with Minimal Change Nephrotic Syndrome
Jung Sue Kim, Hae Il Cheong, Hyun Soon Lee, Yong Choi
Clin Exp Pediatr. 1998;41(12):1675-1684.   Published online December 15, 1998
Purpose : Most of childhood MCNS has a long disease course with frequent relapses. This study was designed to analyze the long-term clinical course of childhood MCNS, focusing at relapsing pattern, treatment response and complications. Mothods : The medical records of 137 children with biopsy-proven MCNS observed during 1976 ti 1996 were analyzed retrospectively. They were classified as initial responders(111 patients,...
Anogenital Index of Normal Children and Its Clinical Significance in Children with Constipation
Kyung Rye Moon
Clin Exp Pediatr. 1998;41(12):1669-1674.   Published online December 15, 1998
Purpose : The purpose of this study was to find an objective criteria to determine the position of normal anus in Korean children and to evaluate the clinical significance of anterior displacement of anus in children with constipation. Methods : Three hundred and thirty-nine normal children and 24 children with idiopathic constipation represented the basis of this study. The position of the normal anus...
Study of a Comparison of Ultrasonography with Radiography to Localize the Umbilical Arterial Catheter
Byoung Min Choi, Young Kwan Park, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 1998;41(12):1650-1659.   Published online December 15, 1998
Purpose : This study was performed to observe the utilization of ultrasonography in locating the position of UAC and to compare the position with anatomical landmarks seen on radiography. Methods : Optimal position is when the catheter tip is located between T6-T10 or L3-L5 by anteroposterior radiography(AP-R) and above the diaphragm by cross-table lateral radiography(CTL-R). Ultrasonographic studies used a Hewlett Packard...
Cardiovascular Doppler Flow Waveforms in Human Fetuses
Young Mi Hong
Clin Exp Pediatr. 1998;41(12):1639-1649.   Published online December 15, 1998
Purpose : Doppler echocardiography has been used to identify fetal cardiac anatomy and hemodynamics. It can estimate flow velocity, volume, and cardiac output. The purpose of this study was to look at cardiovascular waveforms in fetus and to see if there were any changes in Doppler parameter with fetal growth. Methods : Blood velocity studies were performed across the mitral, tricuspid,...
Effects of Cefodizime on Phagocytosis of COS-1 Ccells
Pyoung Han Hwang, Sang Yun Nam, Ho Keun Yi, Min Ho Kim, Kong Soo Kim, Jung Soo Kim
Clin Exp Pediatr. 1998;41(12):1632-1638.   Published online December 15, 1998
Purpose : Cefodizime is a new third-generation cephalosporin which has a structure and immunomodutation properties similar to cefotaxime. Various studies on cefodizime have demonstrated the direct eradication of bacteria in cooperation with the host defense mechanism, particularly with phagocytosis. We evaluated the effects of cefodizime on the phagocytosis of COS-1 cells transfected with FcγRI/γγ or FcγRIIA cDNA. Methods : Phagocytosis was...
A Clinical Analysis on Acute Lower Respiratory Tract Infections in Children Caused by Influenza Virus in Children
Kiehl Hyung Lee, Woo Kyung Kim, Mi Ran Kim, Dug Ha Kim, Hae Ran Lee, Chong Young Park, Kyu Man Lee
Clin Exp Pediatr. 1998;41(12):1623-1631.   Published online December 15, 1998
Purpose : Although annual epidemics occur, there are only a few clinical studies on influenza in Korea. We evaluated the epidemic and clinical features of acute lower respiratory tract infections in children by influenza virus. Methods : From Feb., 1995 to July, 1997, influenza virus isolations and clinical review were performed on hospitalized children with acute lower respiratory tract infections at...
Diagnostic Sensitivity in Predicting Hyperlipidemia by Bioelectrical Impedance Analysis in Obese Children
Ji Ah Jung, Hyun Mi Kim,, Young Mi Hong, Gyoung Hee Kim
Clin Exp Pediatr. 1998;41(11):1583-1589.   Published online November 15, 1998
Purpose : Childhood obesity is currently on the rise. The complications of childhood obesity are depression, adult obesity, hypertension, diabetes, hyperlipidemia, coronary artery disease and fatty liver. Therefore, accurate diagnosis of obesity is important. The purpose of this study was to assess diagnostic sensitivity to predict hypelipidemia by bioelectrical impedance analysis(BI) in obese children. Methods : One hundred fifteen healthy...
A Clinical Study of Histiocytosis Syndrome
Jong Jin Kim, Jae Kook Cha, Kon Hee Lee, Jong Young Park
Clin Exp Pediatr. 1998;41(11):1575-1582.   Published online November 15, 1998
Surgical Treatment for Intractable Childhood Epilepsy
Yoon Jung Cho, Chun Soo Kim, Joon Sik Kim, Chin Moo Kang, Ji Eun Kim, Sang Do Yi, Eun Ik Son
Clin Exp Pediatr. 1998;41(11):1565-1574.   Published online November 15, 1998
Survey on Parental Knowledge about Febrile Convulsion
Sung Koo Kim, Young Jun Kim, Phil Soo Oh, Young Ah Lee, Ha Joo Choi, Hae Sun Yoon
Clin Exp Pediatr. 1998;41(11):1559-1564.   Published online November 15, 1998
Purpose : We surveyed parental knowlege about febrile convulsion in order to reduce unnecessary use of diagnostic method and management, and to use as an educational guideline. Methods : The survey composed of four items : etiology, diagnosis and treatment, prognosis, and method management at home. The rate of correct answers on the total questionnaire, and each questionnaires was compared to...
Compliance with Anticonvulsant Therapy in Epileptic Children
Young Hwan Choi, Ki Sik Min, Jong Wan Kim, Ki Yang Yoo
Clin Exp Pediatr. 1998;41(11):1553-1558.   Published online November 15, 1998
Purpose : Good compliance with an anticonvulsant medication regimen is essential for the successful management of epilepsy. However, pediatric compliance with anticonvulsant therapy did not well be studied. The aim of this study was to identify the following key in noncompliance in pediatric out patients receiving anticonvulsant therapy determining factors. Methods : Eighty-one epileptic outpatients under fifteen years of age with...
Expression of AQP-1 and AQP-4 in Rat Stomach : An Immunohistochemical Study
Seung Il Kim
Clin Exp Pediatr. 1998;41(11):1544-1552.   Published online November 15, 1998
Relationship of Recurrent Abdominal Pain Syndrome and Gastric Emptying Time
Eui Jun Yang, Jae Hong Park, In Ju Kim
Clin Exp Pediatr. 1998;41(11):1538-1548.   Published online November 15, 1998
Purpose : Recurrent abdominal pain syndrome(RAPS) is not uncommon in school-aged children, but the etiology and pathogenesis are not understood well. But recent studies suggest that motility disorder makes up a majority of the pathogenesis. The aim of this study was to investigate gastric emptying time(GET) which is a method to evaluate gastrointestinal motility in patients with recurrent abdominal pain...
Volumetric Quantitation of Pulmonary Regurgitation and Right Ventricular Function in Postoperative Tetralogy of Fallot by Echocardiography and Magnetic Resonance Imaging
Eun Young Park, Il Tae Whang, Young Mi Hong, Yong Sun Won, Yun Hyun Choi
Clin Exp Pediatr. 1998;41(11):1530-1537.   Published online November 15, 1998
Purpose : Despite improved surgical techniques, pulmonary regurgitation is a common postoperative sequelae in patients with tetralogy of Fallot. Pulmonary regurgitation may induce deterioration of right ventricular performance, right ventricular dilatation and ventricular arrhythmia. The evaluation of the clinical significance of pulmonary regurgitation in postoperative tetralogy of Fallot has been troublesome since there was no technique that could accurately quantitate...
Autonomic Activity, Cardiac Chaos and Circadian Rhythm in Asymptomatic Children with Postoperative Tetralogy of Fallot
Myung-Kul Yum, Nam-Su Kim, Jae-Won Oh, Chang-Ryul Kim, Chul-Burm Lee, June Huh, Chung-Il Noh
Clin Exp Pediatr. 1998;41(11):1517-1529.   Published online November 15, 1998
Purpose : This study aimed to characterize the autonomic and chaotic control of heart rate and circadian rhythm in asymptomatic patients with postoperative tetralogy of Fallot(pTOF). Methods : Twenty-four-hour electrocardiogram recordings were obtained in 30 asymptomatic pTOF patients and in 30 age-and sex-matched controls, aged between 6 and 11 years. The data was digitized and partitioned into sections of 30-...
Relationship between Chest Radiography and Cell-mediated Immunity in Mycoplasma pneumoniae Pneumonia
Yong Dae Ham, Jae Il Yoo, Jin Hwa Jeong, Jeong Ho Lee, Jong Dae Cho
Clin Exp Pediatr. 1998;41(11):1509-1516.   Published online November 15, 1998
Purpose : Mycoplasma pneumoniae pneumonias have been one of the most common causes of lower respiratory tract diseases during childhood. It is suggested that pathologic changes seen in the lung tissues were the histologic expression of the host immune response. The aim of this study was to determine the relationship between the chest radiographic pattern of Mycoplasma pneumoniae pneumonia and...
Immune Responses and Efficacy of Hepatitis B Vaccine in Neonates Born from Hepatitis B Carrier Mothers : Focus on HBV-DNA
Jong-Hyun Kim, Jin-Han Kang, Chang-Kyu Oh
Clin Exp Pediatr. 1998;41(11):1498-1508.   Published online November 15, 1998
Purpose : The aim of this study was to elucidate the pathogenesis of vertical transmission of hepatitis B virus(HBV), and to study the protective efficacy of the vaccine and hepatitis B immune globulin(HBIG). Methods : Eighty-two infants born from HBV carrier mothers were studied. HBV plasma-derived vaccine and HBIG were administered to their neonates. Then, changes of viral markers, anti-preS2...
Significance of Acute Phase Reactants(APR) Score for the Early Detection of Neonatal Bacterial Infection
Seong Woo Kim, Myung Ho Oh, Kee Hyuk Kim, Jay G. Sim
Clin Exp Pediatr. 1998;41(11):1491-1497.   Published online November 15, 1998
Purpose : We performed acute phase reactants(APR) test to evaluate as an appropriate screening test for the early detection of neonatal bacterial infection. Methods : We selected 174 neonates and divided into two groups; sepsis group and well-baby group. We performed APR test. Results : There are no significant difference in total leukocyte count, immature to mature rentrophil ratio, toxic granules, and...
Profile of Insulin, Growth Hormone and Insulin-like Growth Factors in Human Cord Blood According to Birth Weight
Hye Young Kim, Dae Yeol Lee, Soo Chul Cho
Clin Exp Pediatr. 1998;41(11):1484-1490.   Published online November 15, 1998
Purpose : Insulin-like growth factors(IGFs) are mitogenic peptides that are essential for fetal and maternal tissue growth during pregnancy. They circulate primarily with serum IGF-binding protein(IGFBP) which regulates the availability of IGFs to their specific target tissue. This study was performed to examine the relationships between birth weight and IGFs, insulin and growth hormone in the sera of cord blood...
Bone Mineral Metabolism and Rickets Compared between Fortified Human Milk and Preterm Formula Feeding in Prematurity
Hong Sun Ju, Eun Young Jeong, Seong Sook Jeon, Son Sang Seo
Clin Exp Pediatr. 1998;41(11):1476-1483.   Published online November 15, 1998
Purpose : To compare the effect of breast milk containing fortifier with preterm formula on bone mineral metabolism in premature infants, we evaluated the state of bone mineralization, biochemical alteration and the frequency of rickets during the first five months of life. Methods : Fourteen fortified breast milk-fed infants and eleven preterm formula-fed infants who were born at Il-Sin...
The Clinical Study on Marfan Syndrome
Jung Sim Kim, Dong Kyu Jin, See Hwan Ko, Jee Yeon Min, I-Seok Kang, Kye Won Jeon, Yung Lan Choi, Heung Jae Lee, Seung Woo Park, Won Ro Lee, Chong Suh Lee, Sei Yeul Oh, Chang Won Ki, Han Wook Yoo, In Sook Park, Jae Kon Ko
Clin Exp Pediatr. 1998;41(10):1411-1416.   Published online October 15, 1998
Purpose : The aim of this study was to assess the involvement of several organs patients with Marfan syndrome in Korea. Also the clinical features in childhood patients with Marfan syndrome were assessed. Methods : Thirty-eight cases of Marfan syndrome were enrolled in this study. Clinical evaluations of the musculoskeletal, cardiovascular and occular system were performed in all cases. Results : The...
Study on Serum Level of Phenobarbital after Intravenous Administration of Loading Dose
Eun Young Park, In Joon Seol
Clin Exp Pediatr. 1998;41(10):1403-1410.   Published online October 15, 1998
Purpose : To learn the changes of phenobarbital serum level after intravenous administration of loading dose and to determine the optimal time of maintenance therapy to support therapeutic concentration. Methods : A total of 24 patients, who were admitted to the pediatric ward for treatment of ongoing and recurrent seizure, were enrolled in this study from November, 1994 to August,...
The Effect of Steroid Therapy on Growth and Bone Density in Children with Nephrotic Syndrome
Seong Hoi Jeon, Ae Yeon Lim, Young Kook Kim, Hae Won Cheon, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 1998;41(10):1396-1402.   Published online October 15, 1998
Purpose : Long-term steroid therapy for various glomerular disorders in children has been known to decrease serum Vit D3 level and develop osteomalacia. The aim of this study was to observe the effect of long-term steroid therapy on growth and bone density in children with nephrotic syndrome. Methods : Bone density of 17 steroid-treated nephrotic syndrome was compared with that of...
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