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The Effect of Low-Dose Dopamine on the Renal Function of Asphyxiated Neonates

Journal of the Korean Pediatric Society 1998;41(12):1685-1692.
Published online December 15, 1998.
The Effect of Low-Dose Dopamine on the Renal Function of Asphyxiated Neonates
Seung Yeon Nam, Eun Ae Par, Seung Joo Lee
Department of Pediatrics, College of Medicine, Ewha Womans University, Seoul, Korea
저용량 Dopamine이 가사 신생아의 신기능에 미치는 영향
남승연, 박은애, 이승주
이화여자대학교 의과대학 소아과학교실
Correspondence: 
Seung Joo Lee, Email: 1
Abstract
Purpose
: Low-dose dopamine(0.5-3μg/kg/min) increases renal blood flow, glomerular filtration rate and natriuresis and has protective and therapeutic effects on oliguric renal failures. Asphyxia is the most common cause of acute renal failure in neonates. But the protective effects of dopamine have never been reported in asphyxiated neonates. So we reported the effects of low-dose dopamine on the renal function of asphyxiated neonates.
Methods
: Twenty-seven asphyxiated neonates who were admitted to the neonatal intensive care unit of Ewha Womans University hospital, from September, 1995 to June, 1997, were randomized to dopamine group(N=14, dopamine 0.5-3μg/kg/min) and control group(N=13). Serum creatinine(Pcr) and Na(PNa), urine creatinine(Ucr) and Na(UNa), urine output, creatinine clearance rate(Ccr), fractional excretion of Na(FENa) of two groups were compared on postnatal day 1, 3, 5. Incidences of acute renal failure and neonatal complications were also checked.
Results
: The postnatal changes of Pcr(mg/dL), Ccr(mL/min/1.73m2) and FENa(%), on lst, 3rd & 5th days were not significnatly diffrent between dopamine group and control group. The postnatal changes of UNa(mmol/day) and urine output(ml/kg/hr) in dopamine group on 1st, 3rd & 5th days were significantly higher than those of control group(P<0.05). The incidence of acute renal failure, intraventricular hemorrhage, bronchopulmonary dysplasia, patient ductus arteriosus, sepsis and necrotizing enterocolitis were not significantly different between two groups.
Conclusion
: Low-dose dopamine, which was prophylactically given after birth in asphyxiated neonates, showed natriuretic and diuretic effects without significant increase of glomerular function.
Key Words: Low-dose dopamine, Renal function, Neonate, Asphyxia


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