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Original Article
Changes in the Findings of 99mTc-dimercaptosuccinic Acid(DMSA) Scan after Acute Pyelonephritis in Childhood and Renal Scar
Sang Hee Ahn, So Young Yoon, Chong Hyun Yoon, Dae Hyuk Moon, Young Seo Park
Clin Exp Pediatr. 2000;43(4):543-549.   Published online April 15, 2000
Purpose : We evaluated the change in the findings of DMSA scan after acute pyelonephritis (APN), and the relationship between renal scar formation and risk factors such as vesicoureteral reflux(VUR), organism and inflammatory reaction. Methods : We examined 200 patients under the age of 5 years with first APN. DMSA scan, voiding cystourethrography(VCUG), erythrocyte sedimentation rate(ESR) and C-reactive protein (CRP) were...
Effect of Liver Transplantation in Children with Fulminant Hepatitis
Young Mee Seo, Bo Hwa Choi, Kyung Mo Kim, Kwang Min Park, Young Joo Lee, Sung Gyu Lee
Clin Exp Pediatr. 2000;43(4):535-542.   Published online April 15, 2000
Purpose : Liver transplantation(LT) is regarded as an important management option for fulminant hepatitis(FH), which is associated with considerable mortality under conservative management. The aim of this study was to evaluate the outcome of children with FH according to management. Methods : We reviewed medical records of patients presented with FH from January 1994 until April 1999. The children were...
Infective Endocarditis in Children : Review of 35 Cases over 11 Years(1987-1997)
Jeong Jin Yu, Young Ho Kwak, Jung-Youn Hong, He Sun Jung, Jin Young Song, Hoan Jong Lee, Chung Il Noh, Jung Yun Choi, Yong Soo Yun
Clin Exp Pediatr. 2000;43(4):526-534.   Published online April 15, 2000
Purpose : Infective endocarditis(IE) is a serious complication in children with structural heart disease. We reviewed 35 cases of IE to identify the recent changes in the pattern of preexisting heart diseases, the spectrum of causative organisms and prognosis. Methods : The clinical records of children diagnosed as IE at the Seoul National University Children`s Hospital from January 1987 through December...
Congenital Heart Anomalies in Patients with Clefts of the Lip and/or Palate
Jin Ho Yu, Jeong Jin Yu, June Huh, Chung Il Noh, Jung Yun Choi, Yong Soo Yu
Clin Exp Pediatr. 2000;43(4):520-525.   Published online April 15, 2000
Purpose : The prevalence of congenital heart anomalies is known to be higher in patients with clefts of the lip and/or palate(CL/P). The purpose of this study was to determine the prevalence and type of congenital heart anomalies in patients with CL/P. Methods : We investigated congenital heart anomalies in 756 patients presented with CL/P from January 1986 to December...
Factors Predictive of Response to Interferon-α Therapy in Children with Chronic Hepatitis B
Hong Kwon Kim, Bo Hwa Choi, Kyung Mo Kim, Kyung Hoon Kang, In Seok Lim, Eung Sang Choi
Clin Exp Pediatr. 2000;43(4):514-519.   Published online April 15, 2000
Purpose : The efficacy and safety of interferon-alpha(IFN-α) therapy in children with chronic hepatitis B(CHB) is similar to that of adults. However, little information is available about the predictive factors of response to this therapy in children. The aim of this study was to determine the predictive factors for responsiveness to IFN-α therapy in children with CHB. Methods : The basal...
Etiologic Agents and Clinical Features of Acute Pyogenic Osteoarthritis in Children
Young Ho Kwak, Su Eun Park, Jung Youn Hong, He Sun Jung, Jin Young Park, Jung Hwan Choi, Hoan Jong Lee, In Ho Choi
Clin Exp Pediatr. 2000;43(4):506-513.   Published online April 15, 2000
Purpose : Though acute pyogenic infections of musculoskeletal system are infrequent in children, delayed diagnosis or inadequate management may cause serious chronic sequelae. We analysed 40 cases of children who were affected by acute septic osteomyelitis and/or septic arthritis to find etiologic agents and to establish proper initial antimicrobial therapy. Methods : Medical records of 40 cases of microbiologically confirmed acute...
Association between Tuberculin Responses and Serum IgE
Pil Ju Jeong, Yong Dae Ham, Jin Hwa Jeong, Jeong Ho Lee
Clin Exp Pediatr. 2000;43(4):502-505.   Published online April 15, 2000
Purpose : Atopy is a state of allergic response, mediated by IgE, to common environmental allergens. In recent decades, there has been an increase in prevalence of atopic disorders in children in developed countries. The factor associated with the rise of atopy incidence may be declining exposure to some infection opportunities. The aim of this study is to determine if...
The Clinical Significance of Cerebrospinal Fluid Interleukin-6 Levels in Viral Meningitis
Eun Joo Ju, In Chul Ahn, Jae Ho Lee
Clin Exp Pediatr. 2000;43(4):496-501.   Published online April 15, 2000
Purpose : Cytokines found at a inflammatory site may be a good indicator of clinical severity of an infectious inflammatory disease. We assayed interleukin 6(IL-6) concentrations in cerebrospinal fluid(CSF) from patients affected with viral meningitis, and verified the relationship between IL-6 and inflammatory parameters and whether IL-6 can be used as a diagnostic marker in the diagnosis of viral meningitis. Methods...
Antibody Response and Adverse Reaction Following Immunization with MMR Vaccine Produced on Human Diploid Cells in Korean Children
Sung Hee Oh, Jin Han Kang, Young Mo Sohn, Hoan Jong Lee, Bok Yang Pyun, Chang Hwi Kim
Clin Exp Pediatr. 2000;43(4):489-495.   Published online April 15, 2000
Purpose : This prospective study was performed to evaluate the immunogenecity and safety of MMR vaccine(Triviraten Berna￠c) in Korea children. Methods : Seventy-three infants aged between 12 to 18 months were recruited from several university hospitals between December 1995 to June 1996. MMR vaccine(Triviraten Berna￠c) was administrered and blood was obtained before and 6-10 weeks after vaccination. IgG antibodies against measles,...
Oscillometric Blood Pressure of Upper and Lower Extremities and Aortic Blood Flow Velocity in Neonates
Sang Young Bae, Hae Soon Kim, Se Jung Sohn, Young Mi Hong
Clin Exp Pediatr. 2000;43(4):484-488.   Published online April 15, 2000
Purpose : We studied the blood pressure difference between the upper and lower extremities in healthy newborn infants and the effect of isthmic narrowing of the aorta on making a possible difference. Methods : The blood pressure was measured with an oscillometric blood pressure device from four extremities of 62 healthy infants aged 1-15 days. A Doppler echocardiography was performed for...
Molecular Epidemiologic Analysis of a Cluster of Klebsiella Pneuminiae Infection in Neonatal Intensive Care Unit
Sung Soo Jin, Jong Hyun Kim, Jae Kyun Hur, Jin-Han Kang
Clin Exp Pediatr. 2000;43(4):477-483.   Published online April 15, 2000
Purpose : Klebsiella pneumoniae is a major nosocomial pathogen in neonatal intensive care unit (NICU). Sequential outbreaks of K. pneumoniae infection in NICU could occur due to antibiotic resistant strains or persistent environmental sources in NICU. When these outbreaks are happen, epidemiological analysis must be performed to discover the nosocomial sources and clarify the nature of the outbreaks strains. We...
Comparison of Intraventricular Hemorrhagic Findings in Preterm Infants Between Brain Ultrasonogram and Magnetic Resonance Imaging at Discharge
Yong Kuk Kim, Sung Suk Do, Mi Hyun Cho, Sang Geel Lee
Clin Exp Pediatr. 2000;43(4):470-476.   Published online April 15, 2000
Purpose : It has been customary to perform brain ultrasonogram(brain US) for the early detection of intraventricular hemorrhage(IVH) during intensive care of neonates. On the other hand magnetic resonance imaging(MRI) has been greatly restrictioned due to its complicated procedures. This study was conducted to identify changes in neonates' brain structure and to gain basic data for the long-term follow-up of...
Apoptosis of Peripheral Blood Mononuclear Cells in Different Ages of Normal Children
Dong Soo Kim, Hyun Young Kim, John A Linton
Clin Exp Pediatr. 2000;43(4):463-469.   Published online April 15, 2000
Purpose : To survive in an ecological environment, an individual must develop immunity to various antigens. Therefore, populations of peripheral blood mononuclear cells(PBMC) in humans change continuously with growth. The object of this study is to evaluate the apoptosis of peripheral blood mononuclear cells(PBMC) in normal children of different ages. Methods : PBMC were isolated from the study groups. Ten...
Diagnostic Significance of the Urine-Stick Test in Middle and High School Children in Seoul
Mi Jung Park, Yun Ju Kang, Jong Hee Kim, Duk Hi Kim
Clin Exp Pediatr. 2000;43(3):411-416.   Published online March 15, 2000
Purpose : This study was performed to assess the diagnostic significance of the urine-stick test in detecting Diabetes Mellitus(DM) and to assess the clinical characteristics of adolescent diabetes. Methods : A total of 926,208 middle and high school children participated. The urine-stick test was performed and those who showed glycosuria and, further studies such as evaluations of plasma glucose, triglyceride, cholesterol...
One Hundred Cases of HLA-matched Sibling Allogeneic bone Marrow Transplantation in Children : Single Center Study
Hack Ki Kim, Bin Cho, Nak Gyun Chung, Dae Chul Jeong, Soh Yeon Kim, Hyun Jung Lee, Kyong Su Lee, Kyung Ja Han, Won Il Kim, Il Bong Choi, Chun Choo Kim
Clin Exp Pediatr. 2000;43(3):402-410.   Published online March 15, 2000
Purpose : We reviewed 100 cases of HLA-matched sibling allogeneic bone marrow transplantation( allo-BMT) in children and wish to share these results. Methods : One hundred children had undergone allo-BMT from HLA-identical siblings between Nov. 1983 and May 1998. There were 50 males and 50 females with a median age of 10 years and a median follow-up of 38 months. Out of 100 cases,...
Study of Autoantibodies Against Platelet GP IIb/IIIa and GP Ib/IX in Childhood Chronic Idiopathic Thrombocytopenic Purpura
Chanwook Woo, Junghwa Lee, Kwangchul Lee, Soonkyum Kim
Clin Exp Pediatr. 2000;43(3):395-401.   Published online March 15, 2000
Purpose : Chronic idiopathic thrombocytopenic purpura(CITP) is an autoimmune disease caused by autoantibodies reacting to certain antigens, and platelet glycoprotein(GP) IIb/IIIa and GP Ib/IX complexes are thought to be some of those antigens. However, the clinical significance of anti-GP autoantibodies in CITP patients is unknown. In this study, we investigated the clinical correlation between the presence of circulating autoantibodies against...
Effect of Hypoxia-ischemia on c-fos Expression in the Neonatal Rat Brain
Wang Bock Lee, Sun Hak Kwon, Heng Mi Kim
Clin Exp Pediatr. 2000;43(3):386-394.   Published online March 15, 2000
Purpose : Brain damage resulting from a combination of hypoxia and ischemia in the newborn infant remains a major cause of perinatal death, cerebral palsy, mental retardation and epilepsy. Metabolic stress, including ischemia, hypoxia and seizures, induces the expression of a variety of stress proteins including nuclear proto-oncogene c-fos. The induction of c-fos can be considered a biomarker of events...
A Study on the Clinical Significance of Periodic Lateralized Epileptiform Discharges and Relation to Brain Imaging Study in Children
Jong Hwa Lee, Eun Young Park, Nam Su Kim, In Joon Seol
Clin Exp Pediatr. 2000;43(3):380-385.   Published online March 15, 2000
Purpose : Periodic lateralized epileptiform discharges(PLEDs), initially described by Chatrian et al in 1964, are an EEG phenomenon characterized by lateralized or focal spike-and-wave complexes with moderate to high voltage which occur in a periodic or semiperiodic pattern. This study was performed to assess the clinical significance of PLEDs and its relation to an imaging study of the brain. Methods :...
Apoptosis of Cord Blood Mononuclear Cells Infected with Enterovirus
Dong Soo Kim
Clin Exp Pediatr. 2000;43(3):372-379.   Published online March 15, 2000
Purpose : To evaluate apoptosis of cord blood mononuclear cells(CBMC) infected with enterovirus. Methods : Cord blood was obtained from 20 neonates which were delivered vaginally without any complications. Cord blood mononuclear cells(CBMC) were isolated, and after 24h and 48h incubation, cells were stained with Annexin V and Propidium Iodide and were analyzed with FACScan flowcytometer. CBMCs were also incubated with...
Physiological Effects of Kangaroo Care(skin-to-skin care) in Small Preterm Infants and Their Parents
Heng-Mi Kim, Soo-Young Kim
Clin Exp Pediatr. 2000;43(3):365-371.   Published online March 15, 2000
Purpose : Kangaroo care is the practice of holding a small premaure infant, naked except for a diaper and hat, against a parent's chest. The purpose of this study is to determine the safety and feasibility of kangaroo care in a NICU as defined by physiological variables. Methods : Ten stable, spontaneously breathing preterm infants, weighing less than 2,000gm were...
The Usefulness of Fluorescence in Situ Hybridization(FISH) in the Diagnosis of Prader-Willi Syndrome
Young Ho Yang, Duk Hee Kim, So Chung Chung, Yong Seok Sohn, Mee Sun Kim
Clin Exp Pediatr. 2000;43(3):360-364.   Published online March 15, 2000
Purpose : To detect microdeletion of 15q11-13 region, high resolution cytogenetic analysis or FISH with probe at Prader-Willi syndrome region can be used. We tried to evaluate whether FISH with SNRPN is a more effective method than G-banding microscope in the diagnosis of Prader-Willi syndrome. Methods : Peripheral blood sampling was done on five patients who we suspected of Prader-Willi syndrome...
Immune Response to SA14-14-2 Live Attenuated Japanese Encephalitis Vaccine
Min Soo Park, Hye Ok Rho, Young Mo Sohn, Laura Chandler, Robert Shope, Theodore F. Tsai
Clin Exp Pediatr. 2000;43(3):351-359.   Published online March 15, 2000
Purpose : SA14-14-2 live attenuated Japanese encephalitis(JE) vaccine has been administered safely and effectively to more than 100 million children in China since 1988, and recently licensure of the vaccine in Korea has been sought. Immune response to the vaccine was investigated. Methods : In the first clinical evaluation of the vaccine outside of China, we monitored side effects in 93...
A Survey on the Adolescent Health Care in Pediatric Practice
Ki Hea Cho, Youn Jung Choi, Young Kyu Shin, Baek Lin Eun, Sang Hee Park, Chang-Ho Hong
Clin Exp Pediatr. 2000;43(3):344-350.   Published online March 15, 2000
Purpose : This study was designed to establish standard guidelines to meet the growing health care needs of adolescents by direct assessment of pediatricians' current practices, attitude and obstacles to the primary care of adolescents. Methods : A questionnaire consisting of 9 questions, including personal characteristics of respondents, current health care practice of adolescents, attitude, obstacles to providing adolescent care, interest...
The Seoul Infant Developmental Screening Test
Keun Lee
Clin Exp Pediatr. 2000;43(3):335-343.   Published online March 15, 2000
Purpose : The importance of early detection of developmental delays during infancy and preschool years has been repeatedly stressed, as early diagnosis of retardation increases the opportunities for effective therapy. Several screening tests developed in other countries are inappropriate for Korean children. The purpose of this study was to standardize a developmental screening method for Korean children. Methods : One hundred...
Anticancer Effect of Arsenic Trioxide in Acute Promyelocytic Leukemia
Ki Young Song, Jin Hye Park, Yoon Jung Cho, Won Ki Baek, Ki Young Kwon, Heung Sik Kim, Chin Moo Kang
Clin Exp Pediatr. 2000;43(3):327-334.   Published online March 15, 2000
Purpose : Acute promyelocytic leukemia(APL or AML, M3) represents an unique model for cancer research in terms of biological and clinical features. Since 1988, it has been widely confirmed that all-trans retinoic acid(ATRA) can induce complete clinical remission in over 85% of APL patients by a differentiation process, with PML-RARα protein possibly being the direct target of ATRA. However, ATRA...
Factors Related to the Outcome of Neonatal Seizures
Sung Koo Kim, Ran Lee, In Kyu Lee, Ki Joong Kim, Young Seung Hwang
Clin Exp Pediatr. 2000;43(2):267-273.   Published online February 15, 2000
Purpose : Seizures during the neonatal period may be an important indicator of serious neurologic abnormalities and can cause permanent neurologic sequelae. We attempted to find and analyze the factors related to the outcome of neonatal seizures. Methods : Seventy-six newborns with seizure were reviewed. The outcomes were analyzed according to etiologic diseases, gestational ages, characteristics of seizure, and neuroimaging and...
Relation between Renal and Scrotal Involvement in Henoch-Schönlein Purpura
Eui Seong Lee, Pyung Kil Kim, Young Kwan Park, Hae Won Cheon, Kee Hwan Yoo
Clin Exp Pediatr. 2000;43(2):260-266.   Published online February 15, 2000
Purpose : Although Henoch-Schönlein purpura(HSP) has been described in detail, there is a paucity of information describing scrotal involvement and risk factors for renal involvement. This study was performed to evaluate the incidence of scrotal involvement and the relationship between renal and nonrenal involvement, including scrotal involvement. Methods : We retrospectively reviewed medical records of 164 male children who were diagnosed...
Medical Therapy in Children with Persistent Hyperinsulinemic Hypoglycemia of Infancy(PHHI)
Hyun-Jeong Kim, Mi-Jeong Kim, Hwa-Sook Shin, Jung-Sim Kim, Mie-Ryung Uhm, Si-Hwan Ko, Suk-Hyang Lee, Dong-Kyu Jin
Clin Exp Pediatr. 2000;43(2):253-259.   Published online February 15, 2000
Purpose : Persistent hyperinsulinemic hypoglycemia of infancy(PHHI), which is characterised by inappropriate insulin secretion in spite of hypoglycemia, needs urgent treatment to prevent cerebral hypoglycemic damage. Although pancreatectomy is the treatment of choice for PHHI, there are several complications which follow treatment. We suggest that aggressive medical therapy, when effective, is preferable to partial pancreatectomy. Methods : We evaluated 8 patients...
Changes in Fat Tissue and Growth Hormone Receptor mRNA after Growth Hormone Therapy
Hye Jung Shin, Duk Hee Kim, So Chung Chung, Kyungyoon Kam
Clin Exp Pediatr. 2000;43(2):247-252.   Published online February 15, 2000
Purpose : Growth hormone(GH) is a powerful inhibitor of lipoprotein lipase and is known to decrease fat cell mass. The lipolytic effect has more pronounced influence on visceral fat than subcutaneous fat. The effects of GH therapy on GH receptor in fat tissue are not clear. We investigated the changes in fat tissue and GH receptor mRNA in adipose tissue...
The Improvement of Cell Viability due to Dilution and Removal of DMSO in Thawing of Stem Cells
Hoon-Kyung Lee, Kyung-Ha Ryu, Il-Tae Whang, Eun Suk Kang, Ki Sook Hong, Kyung-Hyo Kim, Young-Mi Hong, Kyung-Hee Kim, Keun Lee
Clin Exp Pediatr. 2000;43(2):241-246.   Published online February 15, 2000
Purpose : Cryopreserved stem cells from cord blood are usually infused with Dimethyl Sulfoxide (DMSO) immediately after thawing. However, this process may cause cell damage due to osmotic shock, and the administration of DMSO may also cause toxic effects. We studied a new method of increasing cell viability by stabilizing osmolarity by adding dextran 40 and washing out DMSO. Methods :...
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