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Antibody Response and Adverse Reaction Following Immunization with MMR Vaccine Produced on Human Diploid Cells in Korean Children

Journal of the Korean Pediatric Society 2000;43(4):489-495.
Published online April 15, 2000.
Antibody Response and Adverse Reaction Following Immunization with MMR Vaccine Produced on Human Diploid Cells in Korean Children
Sung Hee Oh1, Jin Han Kang2, Young Mo Sohn3, Hoan Jong Lee4, Bok Yang Pyun5, Chang Hwi Kim5
1Department of Pediatrics, College of Medicine, Hanyang University, Seoul, Korea
2Department of Pediatrics, College of M edicine, The Catholic University of Korea, Seoul, Korea
3Department of Pediatrics, College of Medicine, Yonsei University, Seoul, Korea
4Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea
5Department of Pediatrics, College of Medicine, Soonchunhyang University, Korea
한국 소아에 있어 인체 이배체세포 배양 MMR 백신 접종 후 항체반응 및 부작용에 대한 평가
오성희1, 강진한2, 손영모3, 이환종4, 편복양5, 김창휘5
1한양대학교 의과대학 소아과학교실
2가톨릭대학교 의과대학 소아과학교실
3연세대학교 의과대학 소아과학교실
4서울대학교 의과대학 소아과학교실
5순천향대학교 의과대학 소아과학교실
Abstract
Purpose
: This prospective study was performed to evaluate the immunogenecity and safety of MMR vaccine(Triviraten Berna¢c) in Korea children.
Methods
: Seventy-three infants aged between 12 to 18 months were recruited from several university hospitals between December 1995 to June 1996. MMR vaccine(Triviraten Berna¢c) was administrered and blood was obtained before and 6-10 weeks after vaccination. IgG antibodies against measles, mumps and rubella viruses were measured by enzyme immunoassay. Untoward reactions were observed immediately after vaccination and for the following 4 weeks.
Results
: Seroconversion rate against measles virus following MMR vaccination was 100%(18/18, infants), and geometric mean titers(GMT)(95% confidence intervals(CI) before and after vaccination were 3.77(3.13-4.98) and 66.51(49.93-129.62), repectively. Seroconversion rate against mumps virus was 85.9%(55/64 infants), and GMT(95% CI) before and aftervaccination in 32 vaccinees were 3.37(3.05-3.95) and 76.11(71.30-126.70), respectively. Untoward reactions following MMR vaccination were not severe the pre- and post vaccination CBC results were also comparable.
Conclusion
: Antibody response and untoward reactions following MMR vaccination in Korean children appear comparable to previous reports. Further investigation is needed for the immunogenecity of MMR vaccine with a larger population and for the protective efficacy of the vaccine, especially against mumps.
Key Words: Measles, Mumps, Rubella, Vaccination, Immunogenecity, Adverse reaction, Safety


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