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Original Article
A Clinical Study of Acute Symptomatic Seizures in Children
Kyeong Eun Lee, Won Seop Kim
Clin Exp Pediatr. 2000;43(9):1254-1262.   Published online September 15, 2000
Purpose : To determine the incidence, etiology, sex, age, seizure type and prognosis of acute symptomatic seizures in children and evaluate the hypothesis that acute symptomatic status epilepticus( SE) is associated with an increased risk of subsequent unprovoked seizure compared with the risk of acute symptomatic seizure without SE. Methods : Five hundred and sixty-eight convulsive children visited the Pediatric Department of Chungbuk National University...
A Study of Endoscopic Variceal Ligation of under 6-Year-Old Aged Children with Esophagcal Varices
Jeong Hee Moon, Mi Hyon Tae, Nam Seon Beck
Clin Exp Pediatr. 2000;43(9):1241-1247.   Published online September 15, 2000
Purpose : Endoscopic variceal sclerotherapy(EVS) has been considered the mainstay therapy for bleeding esophageal varices in adults. Howevere, recent data have shown that endoscopic variceal ligation is just as efficacious and has fewer complications than EVS. Although there are many reports concerning EVL in adults, only a few studies have been done of children. Methods : We performed EVL in 9...
Hepatitis B Virus Pre-S Gene Mutations in Children with Chronic Hepatitis B Infection
Jae Young Kim, Woo Yeong Chung, Chul Ho Kim
Clin Exp Pediatr. 2000;43(9):1232-1240.   Published online September 15, 2000
Purpose : The envelope of HBV consists of three polypeptides which are encoded in pre-S/S open reading frame. Three translation initiation sites are present within this pre-S/S open reading frame, i.e. pre-S1, pre-S2, and S, allowing the expression of large, middle and small HBs proteins. The pre-S1 is thought to carry the receptor binding site for viral entry into hepatocyte...
Clinical Evaluation of Cyclic Vomiting Syndrome
Jung Mee Cheon, Mee Ryung Um, Mun Hyang Lee, Nam Seon Beck
Clin Exp Pediatr. 2000;43(9):1223-1231.   Published online September 15, 2000
Purpose : To obtain basic data on cyclic vomiting syndrome(CVS) and clinical findings of CVS. Methods : Fifteen patients diagnosed as CVS from April 1995 to July 1999 were enrolled in this study. Results : Among 15 children with CVS(11 boys, 4 girls), 4 patients were put in the migraine group and 11 patients in non-migraine group. The onset age...
Effect of Hypoxia on Antegrade and Retrograde Atrioventricular Conduction in Isolated Perfused Rabbit Heart
Heon-Seok Han, Young Jun Song, Miran Kang
Clin Exp Pediatr. 2000;43(9):1213-1223.   Published online September 15, 2000
Purpose : Cyanotic congenital heart diseases patients are in a state of hypoxia since birth. In general, hypoxia delays atrioventricular conduction. The atrioventricular node in such a hypoxic condition would have a different function, and some possibility for arrhythmia. The authors studied atrioventricular nodal function during hypoxia to elucidate the relationship between hypoxia and arrhythmia, including atrioventricular node in terms...
Significance of Postoperative Peritoneal Drainage and Peritoneal Dialys is in Infants with Congenital Heart Disease Who Underwent Open Heart Surgery
Ji-Hwan Choi, Jae-Hwa Oh, Hyang-Suk Yoon, Jong-Bum Choi, Soon-Ho Choi
Clin Exp Pediatr. 2000;43(9):1207-1212.   Published online September 15, 2000
Purpose : We reviewed 5 years worth of experience with peritoneal drainage and dialiysis in infants who underwent open heart surgery. The aim of this study was to investigate the effect of peritoneal drainage and peritoneal dialysis on fluid on balance and several paramenters od intensive care. Methods : Six(10%) of 60 consecutive infants who underwent open heart surgery required peritoneal...
Transcatheter Closure of the Patent Ductus Arteriosus
Young A Lee, Myung Chul Hyun, Sang Bum Lee
Clin Exp Pediatr. 2000;43(9):1200-1206.   Published online September 15, 2000
Purpose : Transcatheter closure of the patent ductus arteriosus(PDA) is a well-established, effective therapeutic modality, and many kinds of devices have been used to perform this closure. The aim of this study is to compare the effects of different kinds of devices. Methods : We reviewed retrospectively the charts of 43 patients who were admitted to Kyungpook University Hospital between June...
Assessment of Ventricular Function Using Myocardial Performance Index in Patients with Atrial Septal Defect
Ji-Yon Lee, Jo-Won Jung
Clin Exp Pediatr. 2000;43(9):1192-1299.   Published online September 15, 2000
Purpose : This study was designed to define normal values for a nongeometric MPI in children and evaluate the utility of mycoMPI in congenital heart disease with distorted ventricular geometry. Methods : The study population consisted of 44 normal patients and 28 patients with atrial septal defect(ASD) with dilated right ventricle and paradoxical septal motion. Right ventricular(RV) and left...
Morphometric Analysis of the Infundibulum in Tetralogy of Fallot
Su Hee Kwak, Myung Chul Hyun, Sang Bum Lee
Clin Exp Pediatr. 2000;43(9):1187-1191.   Published online September 15, 2000
Purpose : The morphogenic mechanism of tetralogy of Fallot is known to be an antero-superior deviation and hypertrophy of the subpulmonary infundibulum. We performed this study to measure the subpulmonary infundibulum in patients with tetralogy of Fallot and compare those with normal control. Methods : Echocardiographic data and medical reports of 12 patients, with classical tetralogy of Fallot who were diagnosed...
Detection of Herpes Viral DNA in Peripheral Blood of Kawasaki Disease Patient by Nested Polymerase Chain Reaction
Hae-Soon Kim
Clin Exp Pediatr. 2000;43(9):1180-1186.   Published online September 15, 2000
Purpose : Epidemiologic evidence suggests an infectious cause for Kawasaki disease(KD), but the etiology of KD remains unknown. The aim of this study was to determine whether viral infections are related in the pathogenesis of KD by detecting viral genomes using nested polymerase chain reaction. Methods : Peripheral blood was obtained from 18 acute KD patients before administration of intravenous gamma...
Risk Factors for Neonatal Sepsis in Premature Infants Admitted to Neonatal Intensive Care Unit
Chang-Ryul Kim, Jae-Won Oh, Myung-Kul Yum, Soo-Jee Moon
Clin Exp Pediatr. 2000;43(9):1174-1179.   Published online September 15, 2000
Purpose : The purpose of this study is to find out the risk factors of sepsis except the prematurity itself. Methods : Seventy-seven premature infants less than 37 weeks of gestation, who were admitted to the neonatal intensive care unit of Hanyang University Kuri Hospital between July 1995 and December 1996, were enrolled in this study. All 77 premature infants, 14...
Postnatal Changes in Left Ventricular Performance in Early Neonatal Life
Sung Wook Yang, Chan Wook Woo, Jee Youn Lim, Jung Hwa Lee, Joo Won Lee, Chang Sung Son, Young Chang Tockgo, Young Yoo
Clin Exp Pediatr. 2000;43(9):1168-1173.   Published online September 15, 2000
Purpose : This study was undertaken to investigate changes in cardiac performance in early neonatal life by observing the changes of left ventricular(LV) function and volume according to the size of ductus arteriosus. Methods : The study group consisted of 21 full-term Cesarean section neonates who were admitted to the nursery of Korea University Hospital. We serially investigated the...
Factors Influencing the Onset of Honeymoon Period in Children with Type I Diabetes Mellitus
Jin Soon Hwang, Sei Won Yang
Clin Exp Pediatr. 2000;43(8):1106-1110.   Published online August 15, 2000
Purpose : Type I diabetes mellitus(DM) is an autoimmune disease which decreases insulin secretion of pancreatic β-cell. The honeymoon period in type I DM is known to be related to the partial recovery of C-peptide and preservation of pancreatic β-cell function. The aim of this study was to determine factors influencing the onset of honeymoon period in children with type...
Effectiveness of Preoperative Transcatheter Arterial Chemoembolization in Hepatoblastoma
Pyoung Han Hwang, Dae Sun Jo, Dae Yeol Lee, Jung Soo Kim
Clin Exp Pediatr. 2000;43(8):1098-1105.   Published online August 15, 2000
Purpose : To evaluate the effectiveness of transcatheter arterial chemoembolization(TACE) as a preoperative treatment for initially unresectable hepatoblastomas. Methods : From January 1995 to July 1999, we identified two boys and three girls(age range : 5- 27 months; mean age : 12 months) with pathologically-confirmed hepatoblastoma. To assess response to treatment, we utilized an identical TACE procedure for all the patients....
A Prospective Study on Ceftriaxone-associated Biliary Pseudolithiasis : A Dose-related Comparison
Sun Ju Lee, Jun Ho Kim, Jin Hwa Jeong, Sung Min Cho, Sung Tae Park, Dae Seob Choi, Hyeon Kyeong Lee
Clin Exp Pediatr. 2000;43(8):1090-1097.   Published online August 15, 2000
Purpose : Ceftriaxone, a parenteral third-generation cephalosporine, is widely used in the treatment of various bacterial infections. It possesses high calcium-binding affinity, forming complexes with calcium in bile salts to develop precipitate that mimics gallstone on ultrasonography. Biliary pseudolithiasis resolves completely with cessation of therapy, but several symptomatic patients have undergone cholesystectomy. We prospectively evaluated the incidence, risk factors and...
Management of Post-operative Pulmonary Artery Stenosis in Tetralogy of Fallot
Young Seok Lee, In Seung Park, Jae Young Lee, Soo Jin Kim, Mi Young Han, Do Jun Cho, Eun Jung Bae, Seong Ho Kim
Clin Exp Pediatr. 2000;43(8):1081-1089.   Published online August 15, 2000
Purpose : Pulmonary artery stenosis is a common finding in post-operative tetralogy of Fallot (TOF), and it is one of the most frequent indication of reoperation. The objective of this study was to determine the procedural success rate of balloon angioplasty(BAP), endovascular stent, and reoperation for pulmonary artery stenosis in terms of its clinical impact on the subsequent management of...
Repair of Corrected Transposition of the Great Arteries
Soo Jin Kim, Young Seok Lee, Mi Young Han, Jae Young Lee, Do Jun Jo, In Seung Park, Eun Jung Bae, Chang-Ha Lee, Woong-Han Kim, Young-Tak Lee, Seong Ho Kim
Clin Exp Pediatr. 2000;43(8):1074-1080.   Published online August 15, 2000
Purpose : To assess the clinical characteristics and surgical approaches in different anatomical and hemodynamic types of corrected transposition of great arteries(TGA) and learn the surgical results of those patients. Methods : All 52 patients who were diagnosed as corrected TGA between December 1987 and November 1999 and their medical records were reviewed. Three groups were identified according to associated anomalies;...
Change of Cerebrospinal Fluid Ferritin in Children with Meningitis
Mee Hee Youm, Eun Young Kim, Young Jong Woo, Hyun Ju Park, Chan Jong Kim
Clin Exp Pediatr. 2000;43(8):1068-1073.   Published online August 15, 2000
Purpose : Despite the advent of new and more potent antibiotics, mortality and morbidity rates due to bacterial meningitis remain stagnant. Rapid detection of microorganism and early antibiotics treatment are the most important prognostic factors of bacterial meningitis. For early diagnosis of bacterial meningitis biochemical markers such as lactic dehydrogenase, lactic acid, C-reactive proteia have been measured in cerebrospinal fluid....
A Study of Surface Physical Properties of New Surfactant Using Synthetic Peptides of Surfactant Protein-B
Chong-Woo Bae, Yong-Mook Choi, Joo Hyun Kang, Sang-Chul Lee, Kil Lyong Kim, Kyung-Soo Hahm
Clin Exp Pediatr. 2000;43(8):1059-1067.   Published online August 15, 2000
Purpose : To produce a new generation of artificial pulmonary surfactant(PS), surfactant protein (SP)-B from human PSwas isolated, and the amino acid sequences of these proteins were studied. Artificial peptides of human SP-B were synthesized. New artificial PS preparations which were composed of phospholopids and two artificial synthetic SP-B peptides were made, and the surface physical properties of these new PS preparations were tested. Methods...
Neonatal Systemic Candidiasis : Comparison of Albicans and Parapsilosis Infection
Jung Mie Han, Ho Young Lee, Mi Jeong Kang, Sun Young Ko, Yun Sil Chang, Won Soon Park
Clin Exp Pediatr. 2000;43(8):1052-1058.   Published online August 15, 2000
Purpose : Systemic Candidiasis has become an increasingly important cause of morbidity and mortality in NICU infants. Severe infections caused by non-albicans Candida species have been increasingly reported in NICU infants. The purpose of the present study was to compare relative severity, mortality rates for C. albicans(CA) and C. parapsilosis(CP) infections in our NICU. Methods : This study included 16 infants...
The Effect of Massage on Premature Infants
Hee Sook Son, Jae Woo Lim, Kyuchul Choeh, Chang Soo Ra, Hark Hee Kim
Clin Exp Pediatr. 2000;43(8):1046-1051.   Published online August 15, 2000
Purpose : To determine the effects of massage therapy on growth, development, hormones, immune function, hepatic function, hematopoietic function and sleep pattern of preterm infants. Methods : Thirty-one preterm infants of less than 35 weeks gestational age, who were admitted to Eulji Medical College Hospital Neonatal Intensive Care Unit between August 1998 and May 1999, and were in the state without mechanical ventilation or...
A Study on the Prediction of Neurodevelopmental Outcome by Cranial Ultrasound in Preterm and Low Birth Weight Infants
Ji Young Rha, Chang Yee Cho, Young Youn Choi
Clin Exp Pediatr. 2000;43(8):1037-1045.   Published online August 15, 2000
Purpose : Recent progress in neonatal medicine increased the survival of preterm low birth weight infants. However, neurodevelopmental sequelae are ever increasing. We carried out this study to determine whether serial cranial ultrasonographic findings could predict neurodevelopmental outcome. Methods : Four hundred and forty-one preterm low birth weight infants, who were admitted to the Neonatal Intensive Care Unit of Chonnam University...
Oscillometric Blood Pressure Values of Infants and Children
Hae In Suh, Young Mi Hong
Clin Exp Pediatr. 2000;43(8):1029-1036.   Published online August 15, 2000
Purpose : Automated oscillometric blood pressure measurement is not used universally, but has a tendency to be used more frequently in pediatric areas. Reference values of blood pressure by this method were not reported on infants and children under 5 years of age in Korea. This study was performed to study normative blood pressure values by using oscillometric method, presenting...
Insulin-like Growth Factor(IGF)-I and IGF-Binding Protein-3 in Relation to Hemoglobin Concentration in Healthy Infants
Yoon Ki Kang, Dae-Yeol Lee
Clin Exp Pediatr. 2000;43(7):967-973.   Published online July 15, 2000
Purpose : Insulin-like growth factor(IGF-I) and IGF binding protein(IGFBP)-3 is thought to play an important role in fetal erythropoiesis. The objective of this study was to establish a relation between IGF-I, free IGF-I, IGFBP-1, and -3 with hemoglobin level in healthy term, 3-month, and 12-month old infants. Methods : Healthy term infants(n=20) were enrolled at birth, as well as 3 months(n=30) and 12 months(n=30) of...
Effect of Growth Hormone Secretion on Serum Concentration of Leptin
Se-Eun Kim, Jeong-Nyeo Lee, Sang-Ook Nam, Woo-Yeong Chung
Clin Exp Pediatr. 2000;43(7):959-966.   Published online July 15, 2000
Purpose : To investigate the effect of growth hormone(GH) secretion on serum concentration of leptin, we evaluated the differences in serum concentration of leptin between patients with growth hormone deficiency(GHD) and GH normal short stature in prepubertal male children, and the relationship between GH and serum leptin level. Also, we analyzed the correlation between serum concentrations of leptin and insulin-like growth factor-I(IGF-I), insulin-like growth...
A Study of Clinical Features of Acute Tumor Lysis Syndrome in Children
Ick-Jin Song, Young-Tak Lim
Clin Exp Pediatr. 2000;43(7):952-958.   Published online July 15, 2000
Purpose : Tumor lysis syndrome is characterized by hyperuricemia, hyperphosphatemia, hyperkalemia and hypocalcemia due to destruction of tumor cells. The purpose of this study is to estimate in children the incidence, onset time, differences in outcomes between hemodialysis and conservative therapy, and predictive factor of tumor lysis syndrome before treatment with chemotherapy. Methods : Subjects were 108 children who had received...
Induction of Apoptosis of Ewing`s Sarcoma Cells by Regulating Fusion Protein Expression
Ho Keun Yi, Ran Ju Kim, Dae Yeol Lee, Jung Soo Kim, Pyoung Han Hwang
Clin Exp Pediatr. 2000;43(7):942-951.   Published online July 15, 2000
Purpose : Fusion genes(EWS-Fli-1 and EWS-erg ) function as transcription activators and are essential for maintaining tumorigenic properties in Ewing`s sarcoma cells. Several reports have noted that Ets family transcription factors bind with CBP(CREB binding protein) in vitro. To understand the interaction of fusion proteins and CBP, we studied the CBP protein in TC135 cells expressing the EWS-Fli-1 gene. We...
Kinetics of GABAA Receptors in An Animal Model of Irradiation-induced Neuronal Migration Disorders
Chan Jong Kim, Young Jong Woo, Min Cheol Lee
Clin Exp Pediatr. 2000;43(7):933-941.   Published online July 15, 2000
Purpose : A majority of patients with neuronal migration disorders(NMDs) in cortical structures suffer from medically intractable epilepsy. The role of NMDs on seizure susceptibility or epileptogenecity has not been well documented. In the present study, we established an experimental model of NMDs in Sprague-Dawley rats by exposing fetal rats to external irradiation in order to demonstrate epileptogenic effect of NMDs lesions. Methods : Pregnant...
Natural History and Clinical Feature of Multicystic Dysplastic Kidney detected with Prenatal Ultrasonography
Young Lim Shin, Hye Sung Won, Jong Hyun Yoon, Young Seo Park
Clin Exp Pediatr. 2000;43(7):926-932.   Published online July 15, 2000
Purpose : Multicystic dysplastic kidney(MCDK) is characterized by the presence of multiple cysts of varying sizes. It is associated with ureteral or pelviureteral atresia, and a non-functioning kidney. The purpose of this study was to examine the clinical feature and the natural history of MCDK. Methods : A study was performed in 36 children with prenatal diagnosis of MCDK from 1989 to 1999. All...
Selective Gamma Globulin Treatment in Kawasaki Disease : The Comparison between Single 1g/kg and 2g/kg
Su Mi Ihn, Ren Zhe Ann, Hong Ryang Kil, Young Hun Chung
Clin Exp Pediatr. 2000;43(7):920-925.   Published online July 15, 2000
Purpose : Treatment of Kawasaki disease with intravenous gamma globulin(IVGG), together with aspirin, has been demonstrated to be safe and effective in preventing coronary artery lesion and systemic inflammation, but optimal IVGG dosage and administration method are still controversial. We compared the therapeutic efficacy and clinical response of single IVGG 1g/kg to that of IVGG 2g/kg for comparable risk group of Kawasaki disease. Methods :...
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