| Effect of Growth Hormone Secretion on Serum Concentration of Leptin |
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Se-Eun Kim1, Jeong-Nyeo Lee2, Sang-Ook Nam3, Woo-Yeong Chung1 |
1Department of P ediatrics, College of M edicine, Inje University, Pusan, Korea
2Department of Clinical Pathology, College of M edicine, Inje University, Pusan, Korea
3Department of Pediatrics, College of M edicine, Pusan National University, P usan, Korea |
| 성장호르몬 분비가 혈중 Leptin 농도에 미치는 영향 |
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김세은1, 이정녀2, 남상욱3, 정우영1 |
1인제대학교 의과대학 소아과학교실
2인제대학교 의과대학 임상병리학과학교실
3부산대학교 의과대학 소아과학교실 |
Correspondence:
Woo-Yeong Chung, Email: chungwy@chollian.net
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| Abstract |
Purpose
: To investigate the effect of growth hormone(GH) secretion on serum concentration of
leptin, we evaluated the differences in serum concentration of leptin between patients with growth
hormone deficiency(GHD) and GH normal short stature in prepubertal male children, and the
relationship between GH and serum leptin level. Also, we analyzed the correlation between serum
concentrations of leptin and insulin-like growth factor-I(IGF-I), insulin-like growth factor binding
protein-3(IGFBP-3), total cholesterol(TC), free fatty acid(FFA) and body mass index(BMI).
Methods
: Eight cases with GHD and 10 cases with GH normal short stature were included in
this study. Patients were all male, prepubertal children with mean age 10.6 years. Blood samples
were collected in these patients by L-dopa GH provocation test. Statistical analysis of the comparisons
of serum leptin level and correlation of multiple variables were performed using PC-SAS
program. Significance was defined as P < 0.05.
Results
: The mean serum concentration of leptin in GHD(12.27±10.63ng/mL) was significantly
higher than in GH normal short stature(5.39±3.21ng/mL)(P =0.0344). Serum concentration of leptin
was negatively correlated to GH(y=-7.7x＋43.3, r=-0.23, P =0.0109). Serum concentration of leptin
was positively correlated to BMI(y=2.5x－33.3, r=0.75, P =0.0003). Serum concentration of leptin
was not correlated to IGF-I, IGFBP-3, TC and FFA.
Conclusion
: Serum concentration of leptin was siginificantly increased in patients with GHD
compared to GH normal short stature and was negatively correlated to GH. |
| Key Words:
Serum leptin, Growth hormone, Growth hormone deficiency, L-dopa GH provocation test |
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