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Morphometric Analysis of the Infundibulum in Tetralogy of Fallot

Journal of the Korean Pediatric Society 2000;43(9):1187-1191.
Published online September 15, 2000.
Morphometric Analysis of the Infundibulum in Tetralogy of Fallot
Su Hee Kwak, Myung Chul Hyun, Sang Bum Lee
Department of Pediatrics, College of Medicine, Kyungpook National University, Taegu, Korea
Fallot 4징에서 누두부의 형태계측적 분석
곽수희, 현명철, 이상범
경북대학교 의과대학 소아과학교실
Abstract
Purpose
: The morphogenic mechanism of tetralogy of Fallot is known to be an antero-superior deviation and hypertrophy of the subpulmonary infundibulum. We performed this study to measure the subpulmonary infundibulum in patients with tetralogy of Fallot and compare those with normal control.
Methods
: Echocardiographic data and medical reports of 12 patients, with classical tetralogy of Fallot who were diagnosed echocardiographically from Dec. 1996 to Jan. 1999 in Kyungpook National University Hospital, were retrospectively reviewed. A control group consisted of 11 children who underwent a complete echocardiographic examination for a heart murmur and were found to be structually normal. Measurements of the subpulmonary infundibulum were performed in systolic still frames with the subxiphoid short axis view.
Results
: Compared with the normal control children, the following indexed infundibular dimensions in patients with tetralogy of Fallot were significantly smaller : volume, length, cross-sectional area, diameters of pulmonary valve annulus, main, left and right pulmonary arteries, PA index and McGoon ratio. The following measurements were increased in tetralogy patients : the angle between infundibular septum and ventricular septum, and infundibular free wall thickness.
Conclusion
: We confirmed both antero-superior deviation of infundibular septum and infundibular hypoplasia as morphologic abnormalities in tetralogy of Fallot. We also revealed relatively equal contributions of shortening of infundibular length, and increased infundibular septal and free wall thickness to infundibular hypoplasia.
Key Words: Morphometric analysis, Infundibulum, Tetralogy of fallot


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