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The Effect of Tumor Necrosis Factor-α in Cultured Neonatal Rat Cardiomyocytes
Su Jin Kim, Dong Seok Lee, Ok Ko, Il Soo Mun, Bok Hyun Ko, Yong Wook Jung
Clin Exp Pediatr. 2001;44(11):1262-1268.   Published online November 15, 2001
Purpose : Tumor necrosis factor-α(TNF-α) is a pro-inflammatory cytokine that has been implicated in the pathogenesis of cardiovascular disease. Serum levels of TNF-α are elevated in many human cardiac related pathogenic conditions, including heart failure. It is well known that TNF-α inhibits myocardial contractility and induces apoptosis of adult rat cardiomyocytes via stimulation of TNF receptor 1. But pathophysiologically relevant...
A Study on the Risk Factors of Periventricular Leukomalacia in Combined Use with Gentle Ventilation and High-Frequency Ventilation
Suk Ho Kang, Sung Eun Kim, Man Hoi Hur, Sang Geel Lee
Clin Exp Pediatr. 2001;44(11):1254-1261.   Published online November 15, 2001
Purpose : It is suggested that persistent hypocarbia caused by ventilator therapy could be a risk factor in PVL. The study is aimed to discover whether for preventing hypocarbia with combined use of gentle ventilation and high frequency ventilation, other factors would be causers of PVL. Methods : Among 45 infants who were born and survived through ventilator treatment in...
Bystander Effect of HSV-TK/GCV Gene Therapy in Murine Neuroblastoma
Eun Jung Shim, Se Ryoung Kim, Eun Hae Park, Hyun Sang Cho, Jae Kook Cha, Hae Ran Lee
Clin Exp Pediatr. 2001;44(11):1249-1253.   Published online November 15, 2001
Purpose : To demonstrate the bystander effect in murine neuroblastoma model which transduced with HSV-TK gene in vitro and in vivo. Methods : The LNC/TK vector was transfered in vitro into the neuro-2a cells, murine neuroblastoma cell line. Variable mixed populations of neuro-2a cells consisting of HSV-TK＋ or HSV-TK－ were plated into culture plates and treated with GCV for...
Comparison of Brainstem Auditory Evoked Response in Normal Infants, Male and Female, Right and Left Ear
Soo Jin Han, Soo Shin Cho, Kang Ho Cho, EeIl Ryoo, Gwang Hoon Lee, Ho Joon Im, Kye Hwan Seol, Gil Hyun Kim, Hak Soo Lee
Clin Exp Pediatr. 2001;44(11):1243-1248.   Published online November 15, 2001
Purpose : Brainstem auditory evoked response(BAER) is used as screening test for hearing disorders, damages of the central nervous system and congenital anomalies. We studied the difference values according to gender and stimulation sites in normal full-term infants. Methods : We performed BAER in 38 male and 28 female normal full-term infants, delivered in the Gil Medical Center, Gachen Medical School,...
The Role of Aldosterone on the Development of Renal Tubular Reabsorption in Low Birth Weight Infants
Byung Min Choi, Hoe Kyoung Koo, Jin Won Yook, Kyoung Bum Kim, Gi Young Jang, Moon Hee Kim, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 2001;44(11):1233-1242.   Published online November 15, 2001
Purpose : To determine the postnatal changes in aldosterone action on the renal tubular reabsorption in low birth weight(LBW) infants, we assessed the relation of the aldosterone concentrations to renal parameters during the first 10 days of life. Methods : Twenty LBW infants were evaluated and their gestational ages ranged from 32.4 to 39.3 weeks and their birth weights ranged from...
Classification and Risk Factors for Chronic Lung Disease(CLD) of Prematurity : Classical CLD Versus Atypical CLD
Chang Won Choi, Beyong Il Kim, Heui Seung Jo, Jun Dong Park, Chong Jae Kim, Bo Hyun Yoon, Jung-Hwan Choi
Clin Exp Pediatr. 2001;44(11):1222-1232.   Published online November 15, 2001
Purpose : We tried to classify the different type of CLD and assess the risk factors for classical CLD and atypical CLD. Methods : Retrospective cohort analysis was done in 120 preterm infants with birth weights less than 1,500 g who were admitted to NICU in Seoul National University Children's Hospital between Jan. 1993 and Dec. 1998 and survived more...
Serum Level of G-CSF and GM-CSF and CFU-GM Response to Hematopoietic Growth Factors in a Patient with Cyclic Neutropenia
Youn-Kyung Lee, Seok-Hun Kim, Kwang-Woo Kim, Soon Lee, Heung-Sik Kim, Dong-Seok Chun, Kun-Soo Lee
Clin Exp Pediatr. 2001;44(10):1168-1175.   Published online October 15, 2001
Purpose : Serum levels of G-CSF and GM-CSF were measured and CFU-GM assay using G- CSF, GM-CSF and SCF was conducted to evaluate the influence of hematopoietic growth factor on the precursor cells of cyclic neutropenia. Methods : A 7-year-old male with cyclic neutropenia was studied. Marrow mononuclear cells were isolated at neutrophil nadir and recovery and cultured in methylcellulose media...
Evoked Potentials and Cranial Ultrasonography as a Prognostic Method in Newborn with Asphyxia
Hyung Jin Kim, Hee Kang, Byoung Min Choi, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 2001;44(10):1162-1167.   Published online October 15, 2001
Purpose : This study was aimed at finding a diagnostic tool which is useful in predicting the neurologic outcome of the asphyxiated newborns. Methods : 31 newborns with asphyxia were evaluated by brainstem evoked potentials and cranial ultrasonography(CUS). During the neonatal follow-up, we evaluated the development of the babies with Bayley Scale of Infant Development II and INFANIB on corrected age...
Nitroblue Tetrazolium(NBT) Test as a Screening Test of Urinary Tract Infection in Children
Nyun Huh, Chang Hee Oh, Je Woo Kim, Phil Soo Oh, Hae Sun Yoon, Won Keun Song
Clin Exp Pediatr. 2001;44(10):1157-1161.   Published online October 15, 2001
Purpose : It has been reported that the Nitroblue Tetrazolium(NBT) test is more accurate than the urine pH, leukocyte esterase and nitrite test as a screening test of urinary tract infection (UTI). The purpose of this study is to compare the NBT test with other screening tests and evaluate the clinical usefulness of the NBT test as a screening test. Methods...
A Study on the Disease Course and Prognosis of Cyclic Vomiting Syndrome
Hye Ran Yang, Jae Sung Ko, Jeong Kee Seo
Clin Exp Pediatr. 2001;44(10):1141-1156.   Published online October 15, 2001
Purpose : To describe clinical features of cyclic vomiting syndrome(CVS), managements during episodes, prophylactic drugs as long term therapy and to investigate the disease course and prognostic factors of CVS. Methods : Thirty two children who fulfilled the diagnostic criteria of CVS and who presented to Seoul National University Children's Hospital from March 1989 to December 2000, were included. Data were...
Electrophysiologic Study of Cardiac Conduction System in Children
Chae Ok Shin, Myung Chul Hyun
Clin Exp Pediatr. 2001;44(10):1135-1140.   Published online October 15, 2001
Purpose : Pediatric cardiac arrhythmias are increasing but there is no normal values of cardiac electrophysiologic studies(EPS) in Korean children. So we performed cardiac EPS in children undergoing cardiac catheterization for mild congenital heart disease without cyanosis and ECG abnormality. Methods : We studied 24 children(male : 9, female : 15) with mild congenital heart disease(PDA : 10, VSD : 8,...
Clinical Efficacy of Selective Fetal Echocardiography
Su Young Hong, Ji Eun Ban, Young Seok Lee, Hyoung Doo Lee
Clin Exp Pediatr. 2001;44(10):1127-1134.   Published online October 15, 2001
Purpose : The aims of this study was to assess the indication, diagnostic, accuracy and prognostic influence of fetal echocardiography. Methods : From 1995 to 1999, 283 pregnancies were evaluated with fetal echocardiography at Dong-A University Hospital. We reviewed medical records included indication, fetal echocardiographic findings, postnatal echocardiographic findings, methods of treatment and outcome of prenataly diagnosed patients. Results : Family...
The Relationship of Maternal Disorder with Neonatal Cord Blood Leptin - Preeclampsia, Diabetes Mellitus, Antenatal Steroid Treatment -
Seon Mi Park, Eun Young Kim, Yeong Bong Park, Sang Kee Park
Clin Exp Pediatr. 2001;44(10):1119-1126.   Published online October 15, 2001
Purpose : Leptin, the product of the ob gene is primarily by adipose tissue but also by the human placenta. Leptin may also have a role as a regulator of fetal growth and development during normal pregnancy as well as in pregnancies associated with anomalous fetal growth. Our study aimed to discover whether or not leptin concentration in neonatal cord...
Growth and Neurodevelopmental Outcome at 15 Months of Corrected Age in Very Low Birth Weight Infants with Chronic Lung Disease
Seon Young Kim, Chang Yee Cho, Young Youn Choi
Clin Exp Pediatr. 2001;44(10):1112-1118.   Published online October 15, 2001
Purpose : This study was performed to compare the growth and neurodevelopmental outcome at 15 months of corrected age in very-low-birth weight infants between chronic lung disease(CLD) group and the control group. Methods : Very-low-birth-weight infants who were admitted and survived in the NICU(neonatal intensive care units) of Chonnam Univeristy Hospital from Jan. 1997 to Jan. 2000 were divided into...
Relationship between Serum Leptin Levels and Other Predictors in Obese Children
Se Jin Park, Ki Won Park, Young Mi Hong
Clin Exp Pediatr. 2001;44(10):1103-1111.   Published online October 15, 2001
Purpose : The product of the ob gene, leptin is an adipocyte specific hormone that might be involved in the regulation of food intake by the central neuroendocrine system. Recent studies reported that serum leptin concentrations were correlated with Body mass index(BMI) and other obesity measurements. The aims of this study were to evaluate leptin concentrations according to degree of...
Measles, Mumps, and Rubella Immunization in Children with Egg Allergies
Seung Yeon Nam, Eun Hee Jung, Jin A Jung, Yong Min Park, Kyoung Hee Jeon, Ju Suk Lee, Gi Young Jang, Kang Mo Ahn, Sang Il Lee
Clin Exp Pediatr. 2001;44(9):1031-1035.   Published online September 15, 2001
Purpose : The safety of MMR(Measles, Mumps, and Rubella) immunization to children with egg allergies has been debated for decades because the live attenuated virus used in the vaccine is grown in cultured chick-embryo fibroblasts. Many studies that investigated adverse reactions to MMR vaccine have been reported abroad, but there has been no report in Korean children. So, this study is aimed at determining...
Infectious Manifestations in Childhood Leukemia
Yoon Jung Cho, Heung Sik Kim, Chin Moo Kang
Clin Exp Pediatr. 2001;44(9):1019-1030.   Published online September 15, 2001
Purpose : Infection is one of the major causes of morbidity and mortality in children during chemotherapy for leukemia and the development of fever in neutropenic cancer patients frequently indicates infection. The purpose of the present study is to evaluate infectious manifestations during the course of leukemia. Methods : Seventy eight leukemic children who had one or more occasions of infection during hospitalization from January...
Clinical Features and ECG Findings of Supraventricular Tachycardia in Pediatric Patients
Chang Hwan Jang, Myung Chul Hyun
Clin Exp Pediatr. 2001;44(9):1012-1018.   Published online September 15, 2001
Purpose : Supraventricular tachycardia(SVT) is the most frequent symptomatic arrhythmia in children. We performed this study to disover the SVT mechanisms, age at SVT onset, symptoms and ECG findings of SVT and effect of adenosine on SVT. Methods : We studied 57 patients(male : 30, female : 27, age : 1 day-15.8 years) who had been admitted or transferred due to SVT from January,...
The Changes of Production of RANTES and Gro-α in Kawasaki Disease
Young Hwan Lee, Hyun Kyung Lee, Bo Hyeong Lee, Sun Yoon Jung, Hee Sun Kim, Sang Bum Lee
Clin Exp Pediatr. 2001;44(9):1002-1011.   Published online September 15, 2001
Purpose : Kawasaki disease is probably driven by abnormalities of the immune system after infectious insult. In this report, a clinical review with laboratory parameters and the changes of the plasma levels of chemokines(RANTES and Gro-α) was undertaken according to the clinical stage of Kawasaki disease. Methods : This investigation included 74 samples from 21 patients(10 boys, 11 girls; mean age, 27.8 months) with Kawasaki...
Body Composition by Bioelectrical Impedance Analysis in Obese Children
Jong Eun Lee, Ki Won Par, Su Jin Cho, Il Tae Whang, Young Mi Hong
Clin Exp Pediatr. 2001;44(9):992-1001.   Published online September 15, 2001
Purpose : Body composition by bioelectrical impedance analysis(BIA) is a very useful method of analysing body composition in many diseases. BIA is a simple, rapid, non-invasive and reproducible technique. There was no comparative analysis between obese and healthy children. A comparative analysis between obese and healthy children is needed to assess the effect of excercise and other interventions in the management of childhood obesity....
Clinical Analysis of Pediatric Death in Emergency Room
Bo Hyeong Lee, Mi Jung Kim, Hyun Kyung Lee, Young Hwan Lee, Kwang Hae Choi, Seok Hun Song, Sam Beom Lee, Byung Soo Do
Clin Exp Pediatr. 2001;44(9):987-991.   Published online September 15, 2001
Purpose : Sudden, unexpected pediatric death triggers acute grief in most survivors. In this study, we analyzed the pediatric death in emergency room in order to find out the factors for minimized unexpected pediatric death and increase awareness of these conditions. Methods : We performed a review on the records of 63 patients under the age of 16 years who died before and after...
Growth Hormone Receptor Mutation and Partial Growth Hormone Insensitivity in Children with Idiopathic Short Stature
So Chung Chung, Ran Namgung, Duk Hee Kim
Clin Exp Pediatr. 2001;44(8):922-935.   Published online August 15, 2001
Purpose : Children with idiopathic short stature(ISS) are classified on the basis of exclusion criteria. Short stature with normal or increased circulating growth hormone(GH) and low IGF-I levels indicates that partial growth hormone insensitivity(GHI) may play a role in ISS. The present study was performed to investigate whether partial GHI is observed in children with idiopathic short stature and whether...
Evaluation of the Severity in Patients with Bronchial Asthma Using FEF25-75%
Sun Yoon Jung, Eun Sil Lee, Young Hwan Lee, Han Ku Moon
Clin Exp Pediatr. 2001;44(8):916-921.   Published online August 15, 2001
Purpose : Spirometry, because of its simplicity and reproducibility, has been used to evaluate pulmonary function in childhood asthma. We investigated whether FEF25-75% is the most sensitive parameter among other spirometric parameters in the diagnosis of pulmonary function and airway obstruction. Methods : This study included 32 children with asthma. We recorded values of spirometry(FVC, FEV1, PEFR, and FEF25-75%) before and...
QT Dispersion after Chemotherapy with Anthracyclines in Children
Jae Kon Ko, Young Hwee Kim, In Sook Park, Jong Jin Seo, Hyung Nam Moon
Clin Exp Pediatr. 2001;44(8):908-915.   Published online August 15, 2001
Purpose : Anthracycline induced cardiotoxicity is well known and its pathology is characterized by localized myocardial cell necrosis and myocardial fibrosis. The variability in QT interval duration amongst the different leads of the standard 12-lead ECG(QT dispersion) is considered to reflect inhomogenous repolarization of the myocardium. The aim of this study was to assess the effects of anthracycline on cardiac...
The Usefulness of Magnetic Resonance Cholangiography in the Diagnosis of Biliary Atresia
Seok Joo Han, Ki Sup Chung, Myung-Joon Kim, Airi Han, Eui Ho Hwang
Clin Exp Pediatr. 2001;44(8):899-907.   Published online August 15, 2001
Purpose : To evaluate the usefulness of magnetic resonance cholangiography(MRC) for the diagnosis of biliary atresia in infantile cholestatic jaundice. Methods : Fifty consecutive infants with cholestatic jaundice underwent single-shot MRC for 3 years. The radiologic diagnosis of non-biliary atresia with MRC was based on visualization of the common bile duct and common hepatic duct. The diagnosis of biliary atresia was...
Serial Changes of CK, CK-MB after Radiofrequency Catheter Ablation in Pediatric Patients
Se Young Kim, Myung Chul Hyun
Clin Exp Pediatr. 2001;44(8):893-898.   Published online August 15, 2001
Purpose : To investigate the degree of myocardial injury incurred by radiofrequency catheter ablation(RFCA), we serially measured CK, CK-MB levels in 24 pediatric paroxysmal supraventricular tachycardia patients undergoing RFCA(male : 12, female : 12, mean age : 10.5 years, mean weight : 37.2 kg). Methods : We serially measured blood CK, CK-MB levels, 1 day before RFCA(baseline), 8 hours after...
The Measurement of Neonatal Pulmonary Artery Pressure by Echocardiography
Ju Young Chung, Dong Chul Park
Clin Exp Pediatr. 2001;44(8):886-892.   Published online August 15, 2001
Purpose : The main purpose of this study was to conduct accurate noninvasive measurement of the pulmonary artery pressure(PAP) in the neonatal period. The other purpose was to find some descriminant factors that are correlated with pulmonary artery pressure even when there is no tricuspid regurgitation(TR) or patent ductus arteriosus(PDA). Methods : 32 cases of premature and full term infants with...
M-mode Echocardiographic Abnormalities in Infants of Diabetic Mothers
Myung Chul Hyun
Clin Exp Pediatr. 2001;44(8):881-885.   Published online August 15, 2001
Purpose : The purpose of this study was to evaluate M-mode echocardiographic abnormalities in infants of relatively well controlled diabetic mothers and to determine the timing of spontaneous regression. Methods : Echocardiographic study was prospectively carried out in 9 neonates born to diabetic mothers(infants of diabetic mothers, IDM) and 6 newborn infants(control) matched for weight and age. And the study were...
The Detection of Chlamydia trachomatis Using Nested PCR in Prematurity and Delivery of Low Birth Weight Infant
Jae Ho Noh, Hye Kyung Lee, Han Jin Kim, Yong Sik Min, Kyeong Bae Park, Joon Soo Park, Young Chang Kim, Sung Ran Cho
Clin Exp Pediatr. 2001;44(8):875-880.   Published online August 15, 2001
Purpose : Polymerase chain reaction(PCR) has generally been more sensitive than traditional tests for the detection of Chlamydia trachomatis which has been a leading cause of sexually transmitted disease. We performed this study to find out if there is an association between C. trachomatis infection and low birth weight(LBW) or prematurity. Methods : The study included 98 premature or LBW infants...
Usefulness of Serum Prealbumin Concentration as a Marker for Nutritional Adequacy in Premature Infants
Soo Jin Lee, Eun Ae Park, Jeong Wan Seo
Clin Exp Pediatr. 2001;44(8):867-874.   Published online August 15, 2001
Purpose : Serum prealbumin concentration has been proposed as a useful nutritional marker that responds rapidly and sensitively to calory and protein intake. But the reports of prealbumin in premature infants are not sufficient and variable. The purpose of this study was to evaluate the usefulness of serum prealbumin concentration as a marker for nutritional adequacy in premature infants. Methods...
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