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High-dose Intravenous Immune Globulin Retreatment in Kawasaki Disease
So Yun Shim, Mi Young Heo, Hae Soon Kim, Sejung Sonh
Clin Exp Pediatr. 2002;45(10):1273-1277.   Published online October 15, 2002
Purpose : To determine clinical features, laboratory findings and cardiac abnormalities of highdose immune globulin(IVIG) retreatment in patients with Kawasaki disease, and to report effectiveness of retreatment. Methods : Retrospective study of 174 children diagnosed with Kawasaki disease at Ewha Mokdong hospital from March, 1999 to July, 2001. Results : Twenty(11.5%) of 174 patients were retreated with high-dose IVIG. After this, only two patients(1.1%) did not...
Mutational Analysis of MECP2 Gene in 34 Rett Syndrome
Sang Jo Park, Tae Gyu Hwang, Byeong Hee Son, Chul Min Kim
Clin Exp Pediatr. 2002;45(10):1263-1272.   Published online October 15, 2002
Purpose : Rett syndrome(RTT) is an X-linked dominant neurodevelopmental disorder affecting 1 per 10,000-15,000 female births worldwide. It was initially described by Andreas Rett in 1966. RTT involves developmental regression characterized stereotypic hand movements, tremors, gait apraxia, seizures, deceleration of head growth after the age of 6-18 months. The disease-causing gene was identified as MECP2 on chromosome Xq28. We carried out mutational analysis of MECP2...
A Comparative Study of Parental Stress in Families with Epileptic Children
Bo-Young Kim, Sung Min Cho
Clin Exp Pediatr. 2002;45(10):1251-1262.   Published online October 15, 2002
Purpose : The purpose of this study is to assess and compare the stress of mothers and fathers in families with epileptic children, and to assess contributing factors to their stress. Methods : We used a family stress survey with 35 questionnaires to obtain data concerning the parents' perceived stress. Data were analyzed with SPSS 8.0 program using Pearson correlation coefficient, oneway ANOVA, and...
Study on Vaccination State in Children : Jeonbuk Province, 2000
Ju Mi Choung, Jung Chul Kim, So Hee Eun, Pyoung Han Hwang, B. Nyhambat, P. Kilgore, Jung Soo Kim
Clin Exp Pediatr. 2002;45(10):1234-1240.   Published online October 15, 2002
Purpose : This study was carried out to obtain the vaccination rate and age appropriateness of vaccination in children under five years of age in Jeonbuk province. Methods : Eight hundred and fifty infants and children were enrolled in this study. Vaccination rate(Number of vaccinees/Number of subjects), places of vaccination, age appropriateness of vacination were examined by either vaccine record review or interview with...
Comparison of Eosinophil Markers between Acute and Recovery Stages in Children with Mycoplasma pneumoniae Pneumonia
Kyu Min Nah, Eun Kyeong Kang, Hee Kang, Yang Park, Young Yull Koh
Clin Exp Pediatr. 2002;45(10):1227-1233.   Published online October 15, 2002
Purpose : Several studies have shown that increases of eosinophil markers are common findings of asthma and Mycoplasma pneumoniae infection, and eosinophil markers reflect the clinical stage of asthma. The purpose of this study was to investigate the change of eosinophil markers according to the clinical stage of Mycoplasma pneumonia. Methods : The patient group consisted of 33 outpatient children with Mycoplasma pneumonia. Peripheral blood...
The Characteristics of the 2000-2001 Measles Epidemic in the Seoul Metropolitan Area
Dae Hun Pee, So Hoon Byun, Kyung Burm Kim, Young Yoo, Kee Hyoung Lee, Young Kyoo Shin
Clin Exp Pediatr. 2002;45(10):1219-1226.   Published online October 15, 2002
Purpose : To assess the clinical characteristics of the 2000-2001 measles outbreak in the Seoul metropolitan area, Korea, the clinical data of measles inpatients were analyzed. Methods : Three hundred and five children diagnosed with measles by clinical manifestation from July, 2000 to February, 2001, in Seoul, Ilsan and Ansan City were grouped according to their age and investigated for clinical manifestations, vaccination history...
Post-natal Outcome of Fetal Hydronephrosis Detected with Prenatal Ultrasonography
Youn Jin Park, Soon Jung Mun, Chong Woo Bae, Bum Ha Lee, Jin Il Kim
Clin Exp Pediatr. 2002;45(10):1213-1218.   Published online October 15, 2002
Purpose : Hydronephrosis constitutes a great portion of fetal anomalies screened by prenatal sonogram. The present authors made an attempt to access its natural courses through follow up neonatal hydronephrosis diagnosed by prenatal sonogram. Methods : The study was composed of 23 neonates(36 renal units) who were diagnosed with hydronephrosis through prenatal sonogram screening and confirmed 3-7 days after birth with sonographic evaluation at Kyung...
Effect of Nasal Continuous Positive Airway Pressure after Early Surfactant Therapy in Moderate Respiratory Distress Syndrome
Eun Ji Kim, Hae Sook Kim, Man Hoe Hur, Sang Geel Lee
Clin Exp Pediatr. 2002;45(10):1204-1212.   Published online October 15, 2002
Purpose : Early surfactant therapy with either gentle ventilation, high-frequency ventilation or aggressive weaning of mechanical ventilation are principles for the treatment of respiratory distress syndrome(RDS). We studied to determine the accessibility of noninvasive nasal continuous positive airway pressure(CPAP) rather than mechanical ventilation by invasive intubation after early surfactant therapy. Methods : The study group consisted of 14 infants who were born and diagnosed with...
Clinical Significance of Auditory Brainstem Response(ABR) in Speech/Language Disorders
Ki Won Oh, Woo Saeng Park, Soon Hak Kwon, Jin Kyung Kim, Jun Hwa Lee
Clin Exp Pediatr. 2002;45(10):1199-1203.   Published online October 15, 2002
Purpose : The study aimed to evaluate the efficacy of auditory brainstem response(ABR) as a screening tool in children with speech and language disorders. Methods : Between January 1, 1999 and December 31, 2001, 139 patients with chief complaints of speech and language delay were recruited from the pediatric neurology clinic, Kyungpook National University Hospital, Daegu, Korea. They had ABR on entry and the...
Clinical Study of Childhood Accidents from a Hospital Over Ten Years with Regard to Foreign Body Aspiration
Cheol-Min Kim, Jun-Young Song, Ja Hyung Kim, Ki Soo Kim, Soo-Jong Hong
Clin Exp Pediatr. 2002;45(9):1134-1140.   Published online September 15, 2002
Purpose : Childhood accidents have been increasing recently. Accidents rank as the leading cause of childhood mortality and morbidity. We performed this study to evaluate the causes of childhood accidents. Methods : The authors analysed retrospectively the medical records of 6,410 cases of childhood accidental injuries who visited the emergency room of Asan Medical Center from January 1990 to December...
Clinical Characteristics and Genetic Analysis of Prader-Willi Syndrome
Ji Eun Lee, Kwang Bin Moon, Jong Hee Hwang, Eun Kyung Kwon, Sun Hee Kim, Jong Won Kim, Dong Kyu Jin
Clin Exp Pediatr. 2002;45(9):1126-1133.   Published online September 15, 2002
Purpose : Prader-Willi syndrome(PWS) is a complex disorder affecting multisystems with characteristic clinical features. Its genetic basis is an expression defect in the paternally derived chromosome 15q11-q13. We analyzed the clinical features and genetic basis of PWS patients for early detection and treatment. Methods : We retrospectively studied 24 patients with PWS in Department of Pediatrics, Samsung Medical Center, from...
A Study on Central Vein Cannulation Using Audible Doppler Guidance in Children and Infants
Young Joon Ahn, Jin Young Jung, Soo-Jong Hong
Clin Exp Pediatr. 2002;45(9):1120-1125.   Published online September 15, 2002
Purpose : Percutaneous cannulation of the central vein in children and infants may be technically difficult and can cause serious complications. There are many techniques to improve the success rate and to decrease the complications in central vein cannulation. This study was undertaken to determine whether audible Doppler guidance can help operators improve the results of central vein cannultion in...
Abnormal Fractal Correlation of Heart Rate in Children with Neurocardiogenic Syncope
Keoung-Young Kim, Eun-Young Joo, Myung-Kul Yum, Je-Wen Oh, Chang-Ryul Kim, Nam-Su Kim, Cheol-Beom Lee, Chung-Ill Noh
Clin Exp Pediatr. 2002;45(9):1114-1119.   Published online September 15, 2002
Purpose : The purposes of this study were to determine short- and long-term fractal correlation behavior of heart rates during daily activity in patients with neurocardiogenic syncope. Methods : Twenty five patients with histories of neurocardiogenic syncope episodes were included. Their analogue 24h ambulatory Holter electrocardiograms were analyzed. The tape was digitized and the digitized electrocardiograms were partioned into...
iption Factor NF-κB Caused by Acute Hypoxia in the Heart
Chan Uhng Joo, Woo Suk Juhng, Jae Cheol Kim, Ho Keun Yi
Clin Exp Pediatr. 2002;45(9):1106-1113.   Published online September 15, 2002
Purpose : Nuclear factor-κB(NF-κB) is now recognized as playing a potential role in programmed cell death and the adaptive response to various stress. Cellular hypoxia is a primary manifestation of many cardiovascular diseases. It seems that vascular endothelial growth factor (VEGF) and insulin like growth factor-I(IGF-I) have a function as a protective molecule in the heart against several stress including...
Electrocardiographic and Echocardiographic Characterisitics of Wolff-Parkinson-White Syndrome in Preschool Children
Jeoung Min Chu, Hyun Sup Sim, Soo Chul Cho, Chan Uhng Joo
Clin Exp Pediatr. 2002;45(9):1097-1105.   Published online September 15, 2002
Purpose : This study was conducted to estabilish the prevalence, clinical features and relationship between ECG findings and echocardiographic findings of Wolff-Parkinsion-White(WPW) syndrome in asymptomatic preschool children. Methods : An electrocardiographic screening study was performed on 77,824 preschool children in Jeonbuk province from April, 1999 to August, 2001. Patients with WPW syndrome underwent echocardiographic study. Results : Twenty three patients with WPW...
Flexible Bronchoscopic Findings and Therapeutic Effects in Atelectasis of Children
Mee Yong Shin, Jong Hee Hwang, Eun Hee Chung, Jeong Hee Moon, Ju Suk Lee, Yong Min Park, Kang Mo Ahn, Sang Il Lee
Clin Exp Pediatr. 2002;45(9):1090-1096.   Published online September 15, 2002
Purpose : We evaluated the clinical manifestations, bronchoscopic findings and therapeutic effects of flexible fiberoptic bronchoscopy in atelectasis of children. Methods : Sixty six children who received bronchoscopy due to persistent atelectasis, acute severe atelectasis and incidental atelectasis on plain chest radiography were studied retrospectively. Results : The most common causative underlying disease was pneumonia(60.4%). Other underlying conditions were pulmonary tuberculosis, chronic...
Serum Fatty Acid and Carnitine Levels in Obese Children with Fatty Livers
Jin Bum Lee, Jae Won Lee, Young Mi Hong
Clin Exp Pediatr. 2002;45(9):1083-1089.   Published online September 15, 2002
Purpose : The prevalence of obese children has recently increased. Obesity is known to be associated with complications such as hypertension, fatty liver, hyperlipidemia, and insulin resistance. L-carnitine is an essential cofactor for the transport of long chain fatty acids into mitochondria for β-oxidation. The purpose of this study is to measure serum free fatty acid and carnitine levels, and...
Changes of Serum Fatty Acid and Carnitine Levels after Administration of L-carnitine in Rats
Jae Won Lee, Young Mi Hong
Clin Exp Pediatr. 2002;45(9):1075-1082.   Published online September 15, 2002
Purpose : Obesity is known to be associated with hypertension, dyslipidemia, and fatty liver and is thought to be associated with increased levels of free fatty acids. One of the strategies for decreasing free fatty acid levels is stimulation of hepatic lipid oxidation with L-carnitine. Carnitine is an essential cofactor for transport of long-chain fatty acid into mitochondria for oxidation....
Sudden Unexpected Death in Infancy (Analysis of 34 Cases Including 13 Autopsies)
Yeo Ok Moon, Hee Kyoung Choi, Jeoung-A Her, Woo Jong Shin, Myoung-A Kim, Seong Yong Lee, Seong Hee Jang, Eun Sil Dong, Chong Jae Kim, Young Min Ahn, Je Geun Chi
Clin Exp Pediatr. 2002;45(9):1065-1074.   Published online September 15, 2002
Purpose : The purpose of this study is to analyze the epidemiologic characteristics of sudden unexpected death in infancy and to evaluate the importance of postmortem autopsy. Methods : We reviewed, retrospectively, medical records of 34 infants admitted to Kangnam General Hospital from January 1987 to December 2001 because of sudden unexpected death. We investigated the cause of death through medical...
Results of Treatment for Children with Primary Brain Tumors : Long-Term Follow Up Results of a Single Institute
Sung-Yeon Choi, Sung-Chul Won, Chuhl-Joo Lyu, Seung-Hwan Oh, Chang-Hyun Yang, Chang-Ok Suh, Joong-Uhn Choi, Byung-Soo Kim
Clin Exp Pediatr. 2002;45(8):1016-1023.   Published online August 15, 2002
Purpose : Brain tumors are the most common solid tumor in children. We retrospectively investigated the clinical characteristics of pediatric brain tumors, such as age, sex, tumor site and survival, as seen in a single institution over the last 15 years. We tried to evaluate the role of chemotherapy on the survival of some brain tumors. Methods : Three hundred...
A Clinical Study of Children Who Showed Benign Hemophagocytic Histiocytes in Bone Marrow Examination
Jin A Park, Joo Young Park, Ji Min Park, Seat Byoul Park, Heung Sik Kim, Dong Seok Jeon
Clin Exp Pediatr. 2002;45(8):1007-1015.   Published online August 15, 2002
Purpose : The aim of this study is to find a method to diagnose and treat children who showed benign hemophagocytic histiocytes in bone marrow examination. Methods : We analyzed the clinical data of thirty patients retrospectively who showed benign hemophagocytic histiocytes in bone marrow examination from January 1995 to November 2001 at Keimyung University Dong-san Hospital. Bone marrow histiocytes...
Analysis of Etiology and Prognosis of Pulmonary Complications in Children with Hematological or Oncological Disorders in Pediatric Intensive Care Unit
Jin Young Jung, Soo-Jong Hong, Young Jun An, Ja Hyung Kim, Jong Jin Seo, Hyung Nam Moon, Thad Ghim
Clin Exp Pediatr. 2002;45(8):1000-1006.   Published online August 15, 2002
Purpose : In the course of treatment, patients with hematological or oncological disorders often develop pulmonary complication. The patients who develop a severe pulmonary complication have a poor outlook. The causes of pulmonary complication are either infectious or non-infectious in origin. We have analyzed the etiology and outcome of these patients admitted to the pediatric intensive care unit of Asan...
Clinical Features of Subacute Necrotizing Lymphadenitis in Children
Ji Young Hong, Sun Hwan Bae, Wan Sup Kim
Clin Exp Pediatr. 2002;45(8):994-999.   Published online August 15, 2002
Purpose : There is a predilection for subacute necrotizing lymphadenitis(SNL) in young Asian women. Few pediatric cases have been reported. This study was performed to evaluate clinical features of children with SNL. Methods : We retrospectively analyzed clinical features of 23 cases of SNL under 15 years of age identified in Nowon Eulji Hospital from February 1995 to January 2002. Two...
Clinical Features of Patients with Measles during 2000-2001
Sung Ryon Ahn, Su En Park
Clin Exp Pediatr. 2002;45(8):980-986.   Published online August 15, 2002
Purpose : Although the number of patients with measles have dramatically decreased since the introduction of measles vaccines in 1965, measles outbreaks have occurred periodically every 4-6 years during the 1990s(1989-1990 and 1993-1994). During 2000-2001, measles prevailed all over the country again. A characteristic of current epidemics is that the majority of affected population was infants and school-aged children. This...
Comparison of Two Rapid Antigen Detection Tests for Diagnosis of Group A Streptococcal Pharyngotonsillitis
Seung Kyu Song, Mi Ae Hong, Kyung Chang Oh, Seung In Ahn, Mi Hyon Tae, Hye Jung Shin, Jin Keun Chang, Sung Ho Cha
Clin Exp Pediatr. 2002;45(8):973-979.   Published online August 15, 2002
Purpose : Recently, a number of rapid antigen detection tests have been available to diagnose group A streptococcal pharyngotonsillitis. The purpose of this study was to determine the sensitivity, specificity and consistency of the two rapid antigen detection tests. Methods : Among the patients who visited our clinic from November 2001 to February 2002, 61 patients who had clinical findings of...
Usefulness of Low Risk Criteria for Serious Bacterial Infection Among Febrile Infants Younger than Three Months of Age
So Hyun Kim, Ji Ah Jung, Hae-Soon Kim, Eun Sun Yoo, Sejung Sohn, Jeong Wan Seo, Seung Joo Lee
Clin Exp Pediatr. 2002;45(8):967-972.   Published online August 15, 2002
Purpose : A retrospective study was undertaken to evaluate the usefulness of low risk criteria for identifying febrile infants younger than three months unlikely to have serious bacterial infection. Methods : We conducted a retrospective study of 527 infants younger than three month with a axillary temperature ≥37.4℃. If they met the following all four criteria, appear well, WBC 5,000- 20,000/mm3,...
Frequency of Platelet Transfusions and Outcome in Neonates with Thrombocytopenia
Suk-Hwan Lim, Jin-Hwa Kook, Chang-Yee Cho, Young-Youn Choi, Tai-Ju Hwang
Clin Exp Pediatr. 2002;45(8):961-966.   Published online August 15, 2002
Purpose : We compared the underlying or associated diseases according to the frequency of platelet transfusions in neonates with thrombocytopenia to know the factors predicting which patients will require multiple platelet transfusions. We also compared mortality. Methods : A retrospective study was performed in 72 neonates who received the platelet transfusions in neonatal intensive care unit(NICU) between August 1996 and July...
Epidemiological Study of Kawasaki Disease in Kyung Nam Area
Jeong Soo Yang, Eun Young Cho, Hae Sung Jung, Ji Young Hwang, Dong-Jin Lee, Eun Suk No, Myoung-Bum Choi, Chan-Hoo Park, Hee-Shang Youn, Hyang-Ok Woo
Clin Exp Pediatr. 2002;45(7):896-901.   Published online July 15, 2002
Purpose : The aim of this study was to determine the epidemiology of Kawasaki disease in the Kyung Nam area and to evaluate whether the results of this epidemiological study could support infectious etiology. Methods : We sent a questionnaire to three training hospitals in the Kyung Nam area and retrospectively reviewed their medical records of Kawasaki disease from Jun....
Renal Anomalies in Children with Turner Syndrome
Ji Young Kim, Sun Young Hong, Young Mi Park, Yong Hoon Park, Woo Yeong Chung
Clin Exp Pediatr. 2002;45(7):891-895.   Published online July 15, 2002
Purpose : The prevalence of renal anomalies in Turner syndrome(TS) has been reported to vary from 33% to 60%. The purpose of this study was to clarify the true incidence of renal malformations in Korean TS. Methods : We evaluated 33 patients with Turner syndrome diagnosed by karyotype in Inje University Busan Paik hospital and Youngnam University from January 1995....
The Effect of Angiotensin Converting Enzyme Gene Polymorphism in Children with Henoch-Schonlein Purpura Nephritis
Chang Woo Ha, Ji Young Kim, Jeong Nyeo Lee, Jeong Hwa Lee, Woo Yeong Chung
Clin Exp Pediatr. 2002;45(7):884-890.   Published online July 15, 2002
Purpose : Henoch-Schonlein purpura(HSP) nephritis has been reported to vary from 25 to 50% among HSP patients and is a common cause of chronic glomerulonephritis in children. In our study, we evaluated the distribution and the association of the Insertion/Deletion(I/D) polymorphism of angiotensin converting enzyme(ACE) gene with clinical manifestations, particularly proteinuria in children with HSP nephritis, compared with that in...
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