Journal of the Korean Pediatric Society 2002;45(8):961-966.
Published online August 15, 2002.
Frequency of Platelet Transfusions and Outcome in Neonates with Thrombocytopenia
Suk-Hwan Lim1, Jin-Hwa Kook2, Chang-Yee Cho2, Young-Youn Choi2, Tai-Ju Hwang2
1Department of Pediatrics, Mokpo Catholic Hospital, Mokpo,Korea
2Department of Pediatrics, Chonnam National University Medical School, Gwangju, Korea
혈소판 감소증이 있는 신생아에서 혈소판 수혈 횟수와 예후
임석환1, 국진화2, 조창이2, 최영륜2, 황태주2
1목포 가톨릭병원 소아과
2전남대학교 의과대학 소아과학교실
Correspondence: 
Young-Youn Choi, Email: yychoi@chonnam.ac.kr
Abstract
Purpose
: We compared the underlying or associated diseases according to the frequency of platelet transfusions in neonates with thrombocytopenia to know the factors predicting which patients will require multiple platelet transfusions. We also compared mortality.
Methods
: A retrospective study was performed in 72 neonates who received the platelet transfusions in neonatal intensive care unit(NICU) between August 1996 and July 2001. Group I received one platelet transfusion and group II received two or more. We compared the frequency of underlying or assodiated diseases such as sepsis/disseminated intravascular coagulopathy(DIC), respiratory distress syndrome(RDS), intraventricular hemorrhage(IVH), patent ductus arteriosus (PDA), necrotizing enterocolitis(NEC), liver or renal disease, and mortality between two groups.
Results
: Of the 72 patients, 29(40.2%) received one and 43(59.7%) received two or more transfusions; 16(22.2%) received four or more. There were no statistically significant differences in gestational age, birth weight, sex, and maternal history between two groups. C-section rate was higher in group II(20.7% vs. 55.8%, P<0.05) and the incidence of PDA was higher in group I (55.2% vs. 30.2%, P<0.05). Otherwise, there were no statistically significant differences in the incidence of sepsis/DIC, RDS, IVH, RDS, CLD, NEC, liver or renal disease, pulmonary hemorrhage and hypoxic ischemic encephalopathy, and mortality between group I and group II.
Conclusion
: There was no significant difference in clinical morbidity and mortality according to the frequency of platelet transfusion in neonates with thrombocytopenia. Further study is needed to know the predicting factor for multiple platelet transfusions in neonates with thrombocytopenia.
Key Words: Neonate, Thrombocytopenia, Platelet transfusion, Clinical morbidity, Mortality


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