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Young-Joon Ryu

1 Article

Original Article

Neonatology (Perinatology)

Protective effect of recombinant interleukin-10 on newborn rat lungs exposed to short-term sublethal hyperoxia

Hyeon-Soo Lee, Young-Joon Ryu, Min-Jae Lee

Clin Exp Pediatr. 2024;67(10):540-549. Published online September 27, 2024

Crossref 1

Lung injury is generated from the early stage of hyperoxia through the biologic effects of cell death and inflammatory response, which eventually leads to evolution of bronchopul-monary dysplasia. Therefore, a protective measure against hyperoxia-induced lung injury is needed. The present study observed that anti-inflammatory cytokine, interleukin-10 had protective effects on newborn rat lungs from injury induced at the early stage of hyperoxia, by preventing cell death and down-regulating inflammatory response.

DOI: https://doi.org/10.3345/cep.2024.01221

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