- Original Article
- Neuroprotective effects of mild hypoxia in organotypic hippocampal slice cultures
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Seh Hyun Kim, Woo Soon Lee, Na Mi Lee, Soo Ahn Chae, Sin Weon Yun
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Clin Exp Pediatr. 2015;58(4):142-147. Published online April 22, 2015
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Purpose The aim of this study was to investigate the potential effects of mild hypoxia in the mature and immature brain. MethodsWe prepared organotypic slice cultures of the hippocampus and used hippocampal tissue cultures at 7 and 14 days in vitro (DIV) to represent the immature and mature brain, respectively. Tissue cultures were exposed to 10% oxygen for 60 minutes. Twenty-four hours... |
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