Clinical and Experimental Pediatrics

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Original Article

Experimental study on the effect of phenobarbital on Na+, K+-activated adenosine triphosphatase in microsome fractions of mouse brain.

Seo Kyu Kim, Sa Jun Chung, Chang Il Ahn

Clin Exp Pediatr. 1991;34(7):959-970. Published online July 31, 1991

Na+, K+-activated adenosine triphosphatase (Na+, K+-ATPase) is known to play a role as a trigger in neurotransmitter release and may also affect the transport of calcium ion (Ca++). By doing so, Na+, K+-ATPase, as an anticonvulsant, can modify the excitability level of cells in epilepsy. In order to elucidate the possible mechanisms of neuropharmacological interaction between Na+, K+.ATPase and phenobarbital, serial experimental studies were...

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