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S H Park

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Case Report

Three Cases of the Letterer-Siwe Disease.

S H Park, Y C Song, S J Moon, K S Lee

Clin Exp Pediatr. 1980;23(6):501-506. Published online June 15, 1980

Letterer-Siwe disease is a variant of the three diseases exhibiting similar basic histology and entitled histiocysis X. Eosinophilic granuloma of bone and Hand-Schuller-Christan disease complete the triad. Letterer-Siwe disease is a clinieal-pathologic syndrome characterized by onset in infancy and by generalized hyperplasia of nonlipid-storing macrophages in liver, spleen, Lymph nodes, skin and bone marrow, which usually results in fatal outcome....

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