Clinical and Experimental Pediatrics

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Ran Ju Kim (Kim RJ)

2 Articles

Original Article

Induction of Apoptosis of Ewing`s Sarcoma Cells by Regulating Fusion Protein Expression

Ho Keun Yi, Ran Ju Kim, Dae Yeol Lee, Jung Soo Kim, Pyoung Han Hwang

Clin Exp Pediatr. 2000;43(7):942-951. Published online July 15, 2000

Purpose : Fusion genes(EWS-Fli-1 and EWS-erg ) function as transcription activators and are essential for maintaining tumorigenic properties in Ewing`s sarcoma cells. Several reports have noted that Ets family transcription factors bind with CBP(CREB binding protein) in vitro. To understand the interaction of fusion proteins and CBP, we studied the CBP protein in TC135 cells expressing the EWS-Fli-1 gene. We...

The Effect of Milk on the Bioavailability of 6-mercaptopurine

Sun Kyu Park, Ran Ju Kim, Pyoung Ha Hwang, Soo Chul Cho, Jung Soo Kim

Clin Exp Pediatr. 1994;37(12):1732-1737. Published online December 15, 1994

The purine antimetabolite 6-Mercaptopurine (6-MP) has been in clinical use for over 30 years and is still a widely used agent in the treatment of childhood acute lymphoglastic leukemia. The bioavailibility, clinical effecacy and toxicity of 6-MP administered orally for maintenance therapy of children with acute lymphoblastic leukemia are highly variable in many studies, as well as at different times...

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Clinical application of whole exome and genome sequencing in pediatric neurodevelopmental disorders

Human milk macronutrient composition and intake in relation to preterm infant growth: a cohort study

Classification of neurocognitive impairment in pediatric drug-resistant focal epilepsy by quantifying seizure-affected brain network abnormalities in clinical diffusion-weighted imaging connectome

Effects of induction-phase acute kidney injury and age at diagnosis on chronic kidney disease in pediatric acute lymphoblastic leukemia: a time-to-event cohort study

Context-dependent features of transcriptomic landscapes in pregnant mother-neonate dyads of preeclampsia

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