- Original Article
- Anti-angiogenesis and Anti-metastasis Characteristics of the
Novel Tumor Suppressor Gene PTEN
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Pyoung Han Hwang, Ho Keun Yi, Myoung Hee Han, Dae Yeol Lee, Dae Yeol Lee, Jung Soo Kim
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Clin Exp Pediatr. 2001;44(6):654-663. Published online June 15, 2001
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Purpose : The tumor suppressor gene PTEN/MMAC1 is mutated in a variety of advanced and metastatic cancers, strongly suggesting that PTEN/MMAC1 alterations may be involved in tumor progression and the formation of metastases. However, the roles of PTEN in tumor growth and metastasis and its functional mechanisms are not fully understood. We evaluated the tumor suppressor function of PTEN/MMAC1 gene... |
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- Original Article
- Apolipoprotein E Polymorphism and Plasma Lipid Levels in
Obese Children
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Myoung Hee Han, Sun Jun Kim
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Clin Exp Pediatr. 2000;43(5):679-685. Published online May 15, 2000
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Purpose : The increased prevalence of dyslipoproteinemia in obese children probably contributes to the high risk of cardiovascular disease associated with being overweight. The genetic makeup is possible one of the factors that influence the impact of obesity on lipid metabolism. A relation between apolipoprotein E(Apo E) polymorphism and lipid metabolism has been convincingly demonstrated in large population. The purpose... |
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