Clinical and Experimental Pediatrics

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Kye Yang Lee (Lee KY)

1 Article

Original Article

Neuroprotective effects of geneticin (G418) via apoptosis in perinatal hypoxic-ischemic brain injury

Mi Ju, Hyun Ju Lee, Sun Ju Lee, Eo Su Seo, Hye Jin Park, Kye Yang Lee, Gyeong Hoon Lee, Eun Jin Choi, Jin Kyung Kim, Jong Won Lee, Hai Lee Chung, Woo Taek Kim

Clin Exp Pediatr. 2008;51(2):170-180. Published online February 15, 2008

Purpose : Some antibiotics were known to exert neuroprotective effects in the animal model of hypoxic-ischemic (H-I) brain injury, but the mechanism is still unclear. A recent study reported that geneticin (G418), an aminoglycoside antibiotic, increased survival of human breast cancer cells by suppressing apoptosis. We investigated the neuroprotective effects of systemically administrated geneticin via anti-apoptosis following the H-I brain...

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