- Original Article
- A Study of Surface Physical Properties of New Surfactant Using Synthetic Peptides of Surfactant Protein-B
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Chong-Woo Bae, Yong-Mook Choi, Joo Hyun Kang, Sang-Chul Lee, Kil Lyong Kim, Kyung-Soo Hahm
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Clin Exp Pediatr. 2000;43(8):1059-1067. Published online August 15, 2000
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Purpose : To produce a new generation of artificial pulmonary surfactant(PS), surfactant protein
(SP)-B from human PSwas isolated, and the amino acid sequences of these proteins were
studied. Artificial peptides of human SP-B were synthesized. New artificial PS preparations which
were composed of phospholopids and two artificial synthetic SP-B peptides were made, and the
surface physical properties of these new PS preparations were tested.
Methods... |
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- Preparation and in vitro Physical Activities of Crude Natural Surfactant and Artificial Pulmonary Surfactant Containing Synthetic Peptide and Phospholipid Mixtures
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Joo Hyun Kang, Song Yub Shin, Cheol-Young Maeng, Kil Lyong Kim, Chong-Woo Bae, Kyung-Soo Hahm
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Clin Exp Pediatr. 1998;41(4):472-480. Published online April 15, 1998
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Purpose : In this study, natural pulmonary surfactant was extracted from bovine lung lavage and
its surface activity was determined. To investigate the usefulness of synthetic peptides reconstituted
with phospholipid as artificial surfactant, truncated peptides from surfactant protein (SP)-B
were synthesized and restored the surface tension lowering activities when appropriately
recombined with phospholipid.
Methods : Crude natural surfactant(CNS) was isolated from lung lavage by centrifugation... |
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- Surfactant Protein SP-A, B, and C: Purification and Biochemical Characterization
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Chong-Woo Bae, Yong-Mook Choi, Joo Hyun Kang, Kil Lyong Kim, Kyung Soo Hahn
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Clin Exp Pediatr. 1996;39(2):218-229. Published online February 15, 1996
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Purpose : Several kinds of exogenous pulmonary surfactants (SF), either synthetic or animalderived,
are being used for the replacement therapy in respiratory distress syndrome (RDS) of
newborn, especially in premature infants, and improved the neonatal mortality and morbidity.
Because synthetic preparations are lack of surfactant protein (SP) and animal-derived
preparations cause immunogenecity of heterogenous SP, there have been great necessity for the
development of next... |
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