Clinical and Experimental Pediatrics

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Pulmonology

Clinical course of children with postinfectious bronchiolitis obliterans with versus without comorbid bronchopulmonary dysplasia

Lamia Medghoul, Julien Grosjean, Christophe Marguet, Hortense Petat

Clin Exp Pediatr. 2025;68(7):497-502. Published online April 1, 2025

Question: Postinfectious bronchiolitis obliterans (PIBO) is a chronic respiratory disease that typically develops in children after a severe respiratory infection. Bronchopulmonary dysplasia (BPD) is often comorbid in patients with PIBO.
Finding: Corticosteroid pulse therapy effectively manages PIBO with or without comorbid BPD, significantly reducing exacerbations and decreasing the daily requirement for inhaled corticosteroids.
Meaning: Therapeutic effects of corticosteroid pulses are rapid and sustained over time, in both groups.

DOI: https://doi.org/10.3345/cep.2025.00122

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