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Acetaminophen causes neurodevelopmental injury in susceptible babies and children: no valid rationale for controversy

Lisa Zhao, John P. Jones, Lauren G. Anderson, Zacharoula Konsoula, Cynthia D. Nevison, Kathryn J. Reissner, William Parker

Clin Exp Pediatr. 2024;67(3):126-139. Published online June 14, 2023

Web of Science 4 Crossref 4

Despite worldwide acceptance of acetaminophen (paracetamol) in pediatric medicine, careful examination reveals no valid objections to the conclusion that early exposure to acetaminophen causes neurodevelopmental injury in susceptible babies and children. Nevertheless, debate that early exposure to acetaminophen causes neurodevelopmental injury has centered around the prenatal period, evidence of which is relatively limited compared to that in the postnatal period, which is the time of greatest absolute and relative risk.

DOI: https://doi.org/10.3345/cep.2022.01319

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