Clinical and Experimental Pediatrics

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In Sun Bae (Bae IS)

1 Article

Original Article

Effect of angiotensin II inhibition on the epithelial to mesenchymal transition in developing rat kidney

Hyung Eun Yim, Kee Hwan Yoo, In Sun Bae, Young Sook Hong, Joo Won Lee

Clin Exp Pediatr. 2009;52(8):944-952. Published online August 15, 2009

Purpose:To investigate the effects of angiotensin II inhibition on the epithelial to mesenchymal transition (EMT) in the developing kidney, we tested the expression of EMT markers and nestin in angiotensin converting enzyme (ACE) inhibitor-treated kidneys. Methods:Newborn rat pups were treated with enalapril (30 mg/kg/d) or a vehicle for 7 days. Immunohistochemistry for the expression of α-smooth muscle actin (SMA), E-cadherin, vimentin, and nestin were...

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