- Original Article
- Iron chelating agent, deferoxamine, induced apoptosis in Saos-2 osteosarcoma cancer cells
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Eun Hye Park, Hyo Jung Lee, Soo Yeon Lee, Sun Young Kim, Ho Keun Yi, Dae Yeol Lee, Pyoung Han Hwang
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Clin Exp Pediatr. 2009;52(2):213-219. Published online February 15, 2009
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Purpose : Iron is a critical nutritional element that is essential for a variety of important biological processes, including cell growth and differentiation, electron transfer reactions, and oxygen transport, activation, and detoxification. Iron is also required for neoplastic cell growth due to its catalytic effects on the formation of hydroxyl radicals, suppression of host defense cell activities, and promotion of... |
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- Capsaicin induced apoptosis and the enhanced anticancer
effect of anticancer drugs in cancer cells
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Sun Young Kim, You Jin Lee, Eun Hye Park, Ho Keun Yi, Dae Sun Jo, Jung Soo Kim, Pyoung Han Hwang
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Clin Exp Pediatr. 2008;51(3):307-314. Published online March 15, 2008
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Purpose : Capsaicin, the major pungent ingredient in red pepper, has long been used in spices and food additives. It has been recently shown to induce apoptosis in several cell lines through a not well known mechanism. The aim of this study was to investigate the apoptosis-inducing effect of capsaicin on gastric cancer cells, and to provide valuable information concerning... |
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- Epidemiologic and Clinical Features of
Pertussis in Children(2000. 3-2001. 3)
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Shin Yoo, Kyong Ouk Ahn, Eun Hye Park, Hyun Sang Cho, Chong Young Park, Hae Ran Lee
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Clin Exp Pediatr. 2002;45(5):603-608. Published online May 15, 2002
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Purpose : Pertussis is a highly communicable infectious disease in children with high mortality, especially in young infants. The incidence of pertussis in South Korea has decreased to about 10 cases a year in late '90s. Doubting previously reported incidences of pertussis, we designed this study to establish exact epidemiology and a diagnostic basis of pertussis.
Methods : From Mar. 2000... |
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- Case Report
- A Case of Encephalopathy Presented with Motor Aphasia and Quadriplegia Following Intrathecal Methotrexate
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Seon Woo Lee, Eun Hye Park, Hyun-Sang Cho, Jae Kook Cha, Hae Ran Lee
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Clin Exp Pediatr. 2001;44(9):1066-1069. Published online September 15, 2001
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Intrathecal administration of methotrexate(IT-MTX) has constituted the standard approach to prophylaxis
and treatment of central nevous system(CNS) leukemia. We experienced a quadriplegia
and motor aphasia in a 14-year-old boy following repeated IT-MTX for the prophylaxis of
meningeal leukemia. He was diagnosed as ALL without CNS involvement and treated by CCG-
1882 protocol. IT-MTX was administered for CNS prophylaxis. The patient began complaining of
urinary incontinence,... |
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