Clinical and Experimental Pediatrics

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Dong-Seok Lee (Lee DS)

1 Article

Original Article

Protective Effect of Probucol against Adriamycin-Induced Apoptosis in Cultured Rat Cardiac Myocytes

Sun-Ju Lee, Dong-Seok Lee, Yong-Wook Jung

Clin Exp Pediatr. 2000;43(6):746-754. Published online June 15, 2000

Purpose : In adriamycin(ADR)-induced cardiomyopathy, several different mechanisms are suggested. However, little information is available regarding the role of apoptosis. In the present study, we examined the induction of apoptosis on ADR treatment and anti-apoptotic effects of probucol, a lipid-lowering drug, and we also studied the changes of bcl-2 expression in order to see the molecular mechanisms underlying the effect...

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