- Original Article
- Association study of polymorphism in leukotriene C4 synthase and cysteinyl leukotriene receptor 1 genes with phenotype of asthma and clinical parameters in Korean children
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Jung Yeon Shim, Byung-Joo Kim, Young Hwa Song, Mi-Jin Kang, So-Yeon Lee, Jinho Yu, Soo-Jong Hong
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Clin Exp Pediatr. 2009;52(6):680-688. Published online June 15, 2009
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Purpose : Cysteinyl leukotrienes are important proinflammatory mediators in asthma. Recently, it was suggested that a promoter polymorphism in the genes encoding for leukotriene C4 synthase (LTC4S), a key enzyme in the leukotriene synthetic pathway, and cysteinyl leukotriene receptor 1 (CysLTR1) might be associated with aspirin-intolerant asthma. We investigated whether polymorphisms in LTC4S and CysLTR1 genes or their interactions were... |
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