- Review Article
- Hematology
- Promising role of voxelotor in managing sickle cell disease in children: a narrative review
-
Amit Agrawal, Gaurav Jadon, Japna Singh, Dalwinder Janjua
-
Clin Exp Pediatr. 2025;68(2):106-114. Published online November 13, 2024
-
|
Voxelotor has promising ability to increase hemoglobin levels and reduce hemolysis markers in patients with sickle cell disease (SCD). Several preclinical and phase II/III trials have demonstrated its efficacy, dose-dependent responses, and tolerability in children. Ongoing trials are assessing its safety and effectiveness in various populations, including children younger than 12 years. These findings suggest its potential as a disease-modifying drug, warranting further exploration of its role in SCD management. |
-
-
- Cardiology
- Heart failure in children and adolescents: an update on diagnostic approaches and management
-
Amit Agrawal, Dalwinder Janjua, Abdulrahman Ahmed Alsayed Ali Zeyada, Ahmed Taher Elsheikh
-
Clin Exp Pediatr. 2024;67(4):178-190. Published online June 19, 2023
-
|
· Pediatric heart failure (PHF) is a clinical syndrome featuring various symptoms (shortness of breath, ankle swelling, fatigue) and signs (pulmonary crackles, peripheral edema).
· Congenital heart diseases are the most common underlying etiology of PHF, whereas myocarditis and primary cardio-myopathies are common in children without structural ab-normalities.
· PHF pathophysiology is complex and multifactorial and varies by etiology and age.
· PHF management includes decongestive therapy, treatment of underlying causes, preventing progression, and managing pulmonary or systemic obstructions.
· Drugs should be chosen based on pharmacodynamics, clinical manifestations, hemodynamic state, and renal function. |
-
-
- Exploring nutritional screening tools for hospitalized
children: a narrative review
-
Pankaj Soni, Amit Agrawal, Gaurav Jadon
-
-
|
|
Malnutrition is common among hospitalized children,
especially those who are critically ill. Routine measures,
such as anthropometric measurements, body composition,
and nutritional assessment, comprise the basics
of monitoring. This review discusses the adequacy of
nutritional screening tools (NSTs) such as the SGNA
(Subjective Global Nutritional Assessment), PYMS (Pediatric
Yorkhill Malnutrition Score), STAMP (Screening
Tool for the Assessment of Malnutrition in Paediatrics),
and STRONGkids (Screening Tool for Risk of Nutritional
Status... |
-
-
|
