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Original Article
Risk factors of ocular involvement in children with mitochondrial respiratory chain complex defect
Jung Hyun Chae, Jung Hun Lee, Kyo Ryung Kim, Suk Ho Byeon, Young Mock Lee, Hoon Chul Kang, Joon Soo Lee, Heung Dong Kim
Clin Exp Pediatr. 2010;53(12):994-999.   Published online December 31, 2010
Purpose

Mitochondrial dysfunction can present with various symptoms depending on the organ it has affected. This research tried to analyze the ophthalmologic symptoms and ophthalmologic examination (OE) results in patients with mitochondrial disease (MD).

Methods

Seventy-four patients diagnosed with mitochondrial respiratory chain complex defect with biochemical enzyme assay were included in the study. They were divided into 2 groups based on the OE...

Electrocardiography as an early cardiac screening test in children with mitochondrial disease
Ran Baik, Jung Hyun Chae, Young Mock Lee, Hoon Chul Kang, Joon Soo Lee, Heung Dong Kim
Clin Exp Pediatr. 2010;53(5):644-647.   Published online May 31, 2010
Purpose

To evaluate myocardial conductivity to understand cardiac involvement in patients with mitochondrial disease.

Methods

We performed retrospective study on fifty-seven nonspecific mitochondrial encephalopathy patients with no clinical cardiac manifestations. The patients were diagnosed with mitochondrial respiratory chain complex defects through biochemical enzyme assays of muscle tissue. We performed standard 12-lead electrocardiography (ECG) on all patients.

Results

ECG abnormalities were observed in 30 patients (52.6%)....

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