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Original Article
Other
Korean parents’ perceptions of the challenges and needs on school re-entry during or after childhood and adolescent cancer: a multi-institutional survey by Korean Society of Pediatric Hematology and Oncology
Jun Ah Lee, Jae Min Lee, Hyeon Jin Park, Meerim Park, Byung Kiu Park, Hee Young Ju, Ji Yoon Kim, Sang Kyu Park, Young Ho Lee, Ye Jee Shim, Heung Sik Kim, Kyung Duk Park, Yeon-Jung Lim, Hee Won Chueh, Ji Kyoung Park, Soon Ki Kim, Hyoung Soo Choi, Hyo Seop Ahn, Jeong Ok Hah, Hyoung Jin Kang, Hee Young Shin, Mee Jeong Lee
Clin Exp Pediatr. 2020;63(4):141-145.   Published online November 14, 2019
Question: What are the parental needs and challenges when their children return to school after cancer?
Finding: In addition to scholastic aptitude-oriented programs, emotional and psychosocial support is necessary for a successful return to school.
Meaning: Pediatric oncologists should actively engage in improving oncology practices to better integrate individualized school plans and educate peers and teachers to improve health literacy to make them understand the needs of children with cancer.
Case Report
Oncology
Targeted busulfan and fludarabine-based conditioning for bone marrow transplantation in chronic granulomatous disease
Hee Young Ju, Hyoung Jin Kang, Che Ry Hong, Ji Won Lee, Hyery Kim, Sang Hoon Song, Kyung-Sang Yu, In-Jin Jang, June Dong Park, Kyung Duk Park, Hee Young Shin, Joong-Gon Kim, Hyo Seop Ahn
Clin Exp Pediatr. 2016;59(Suppl 1):S57-S59.   Published online November 30, 2016

Chronic granulomatous disease (CGD) is a primary immunodeficiency disease caused by impaired phagocytic function. Hematopoietic stem cell transplantation (HSCT) is a definitive cure for CGD; however, the use of HSCT is limited because of associated problems, including transplantation-related mortality and engraftment failure. We report a case of a patient with CGD who underwent successful HSCT following a targeted busulfan and...

Hemophagocytic lymphohistiocytosis diagnosed by brain biopsy
Hee Young Ju, Che Ry Hong, Sung Jin Kim, Ji Won Lee, Hyery Kim, Hyoung Jin Kang, Kyung Duk Park, Hee Young Shin, Jong-Hee Chae, Ji Hoon Phi, Jung-Eun Cheon, Sung-Hye Park, Hyo Seop Ahn
Clin Exp Pediatr. 2015;58(9):358-361.   Published online September 21, 2015

Hemophagocytic lymphohistiocytosis (HLH) is characterized by fever, splenomegaly, jaundice, and pathologic findings of hemophagocytosis in bone marrow or other tissues such as the lymph nodes and liver. Pleocytosis, or the presence of elevated protein levels in cerebrospinal fluid, could be helpful in diagnosing HLH. However, the pathologic diagnosis of the brain is not included in the diagnostic criteria for this...

Review Article
Umbilical cord blood transplantation
Hong Hoe Koo, Hyo Seop Ahn
Clin Exp Pediatr. 2012;55(7):219-223.   Published online July 17, 2012

Since the first umbilical cord blood transplantation (CBT) in 1998, cord blood (CB) has now become one of the most commonly used sources of hematopoietic stem cells for transplantation. CBT has advantages of easy procurement, no risk to donor, low risk of transmitting infections, immediate availability and immune tolerance allowing successful transplantation despite human leukocyte antigen disparity. Several studies have...

Recent advance in primary immune deficiency disorders
Hyoung Jin Kan, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 2009;52(6):649-654.   Published online June 15, 2009
The immune system is comprised of cells and molecules whose collective and coordinated response to the introduction of foreign substance is referred to as the immune response. Defense against microbes is mediated by the early reaction (innate immunity) and the late response (adaptive immunity). Innate immunity consists of the epithelial barrier, phagocytes, complement and natural killer cells. Adaptive immunity, a...
Acute lymphoblastic leukemia in children: past, present and future
Hyoung Jin Kang, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 2007;50(7):601-605.   Published online July 15, 2007
The cure rate of acute lymphoblastic leukemia (ALL) in children dramatically improved over past 5 decades from zero to about 80%. The main cause of improvement is owing to the development of chemotherapy by multicenter clinical trial of large study groups with the understanding of leukemia biology. Recently, pediatric ALL protocols were applied to the treatment of adolescent and even...
Original Article
Factors affecting the final adult height in survivors of childhood brain tumors
Kyong-Ah Yun, Young Ah Lee, Choong Ho Shin, Sei Won Yang, Hee Young Shin, Hyo Seop Ahn, Il Han Kim
Clin Exp Pediatr. 2007;50(1):65-73.   Published online January 15, 2007
Purpose : Short stature is an important complication that impairs the quality of life in survivors of childhood brain tumors. We studied their final adult height (FAH) to evaluate risk factors for short stature. Methods : We reviewed the medical data of 95 survivors of childhood brain tumors (64 males and 31 females) who had been followed up from 1982 to...
Etiological agents isolated from blood in children with hemato-oncologic diseases (2002-2005)
So-Hee Kim, Young-Ah Lee, Byung-Wook Eun, Nam-Hee Kim, Jin-A Lee, Hyoung Jin Kang, Eun-Hwa Choi, Hee Young Shin, Hoan-Jong Lee, Hyo Seop Ahn
Clin Exp Pediatr. 2007;50(1):56-64.   Published online January 15, 2007
Purpose : This study was performed to identify the etiologic agents and antimicrobial susceptibility patterns of organisms responsible for bloodstream infections in pediatric cancer patients for guidance in empiric antimicrobial therapy. Methods : One hundred and ninety-seven episodes of bloodstream infections that developed in 128 pediatric cancer patients were analyzed, which were identified at the Seoul National University Children's Hospital during...
Endocrine dysfunction and growth in children with medulloblastoma
In Suk Yoon, Ji Young Seo, Choong Ho Shin, Il Han Kim, Hee Young Shin, Sei Won Yang, Hyo Seop Ahn
Clin Exp Pediatr. 2006;49(3):292-297.   Published online March 15, 2006
Purpose : In medulloblastoma, craniospinal radiation therapy combined with chemotherapy improves the prognosis of tumors but results in significant endocrine morbidities. We studied the endocrine morbidity, especially growth pattern changes. Methods : The medical records of 37 patients with medulloblastoma were reviewed retrospectively for evaluation of endocrine function and growth. We performed the growth hormone stimulation test in 16 patients whose...
Case Report
Development of Crohn disease in patients with myelodysplastic syndrome : report of two children
Jeong Ok Shim, Jeong Kee Seo, Hye Ran Yang, Jae Sung Ko, Hee Young Shin, Hyo Seop Ahn, Woo Sun Kim, Gyeong Hoon Kang
Clin Exp Pediatr. 2006;49(1):107-111.   Published online January 15, 2006
Crohn disease (CD) is rare, but the incidence of CD has been increasing over the past ten years. We found two cases of CD, associated with myelodysplastic syndrome (MDS), for the first time in children. In the first patient, MDS was diagnosed at three years of age and CD developed later at eight years of age. The patient presented with...
Original Article
Follow-up Study of Children with Anthracycline Cardiotoxicity
Hyok Joo Kwon, Young Hwan Song, Soo Jung Kang, Hyoung Jin Kang, Hyoung Soo Choi, Eun Jung Bae, Hee Young Shin, Chung Il Noh, Yong Soo Yun, Hyo Seop Ahn
Clin Exp Pediatr. 2003;46(3):242-249.   Published online March 15, 2003
Purpose : We studied the relationship between anthracycline cumulative dose and anthracycline cardiotoxicity in childhood cancer and followed up 40 children with anthracycline cardiotoxicity. Methods : A retrospective study was performed in 154 children who received anthracycline chemotherapy between January 1995 to December 2000. Cardiotoxicity was defined when the left ventricular fractional shortening(FS) was below 26%; it was divided into two...
Therapeutic Effect of Different Doses of Recombinant Human Granulocyte Colony-Stimulating Factor(rhG-CSF) on Neonatal Sepsis Complicated by Neutropenia
Moon Young Choi, Yeon Sook Jung, Dong Woo Son, Hyo Seop Ahn
Clin Exp Pediatr. 2002;45(4):439-448.   Published online April 15, 2002
Purpose : The aim of this study is to determine and compare the effects of adjunctive therapy with different doses of recombinant human granulocyte-colony stimulating factor(rhG-CSF) on reversing sepsis-associated neonatal neutropenia, and their survival rate in a group I/II-type trial. Methods : RhG-CSF was injected subcutaneously to 10 septic-neutropenic neonates with doses of 10 μg/kg from Oct. 1995 to Sep. 1996,...
Case Report
A Case of Hepatoblastoma with Precocious Puberty
Chang Won Choi, Hyun Jin Park, Ki Woong Sung, Eun Sun Yoo, Hee Young Shin, Sei Won Yang, Hyo Seop Ahn
Clin Exp Pediatr. 2000;43(2):288-293.   Published online February 15, 2000
Hepatoblastoma is the most common primary malignant liver tumor in childhood. Most cases are boys generally below three years of age. Hepatoblastoma are associated with various non-metastatic syndromes. Rarely, human chorionic gonadotropin may be produced by the tumor. Ectopic gonadotropin production from this source is a rare cause of precocious puberty in boys. Since a report by Behrendt in 1931,...
Original Article
Clinical Significance of CD7 Expression in Acute Myelocytic Leukemia
Gye Jin Yoon, Pill Sang Jang, Young Choi, Jun A Lee, Hyo Jung Han, Hyoung Soo Choi, Hee Young Shin, Joong Gon Kim, Hyo Seop Ahn
Clin Exp Pediatr. 1999;42(3):374-382.   Published online March 15, 1999
Purpose : It has been shown that a considerable number of acute myeloid leukemia(AML) patients had both myeloid and lymphoid antigens. CD7 is a lymphoid antigen, often expressed in AML cells. We investigated 40 AML patients to clarify the relationship between the cellular characteristics and clinical features. Methods : We reviewed 8 CD7 positive(CD7＋) AML patients and 32 CD7 negative(CD7－)...
Immunomodulation Therapy in Aplastic Anemia : Relapse Rate, Complications and Long-term Survival During Follow-up for More than 1 Year
Jun Ah Lee, Hyoung Jin Kang, Hyo Jeong Han, Hyoung Soo Choi, Eun Sun Yoo, Hee Young Shin, Joong Gon Kim, Hyo Seop Ahn
Clin Exp Pediatr. 1998;41(6):775-784.   Published online June 15, 1998
Purpose : We evaluated the response to immunomodulation therapy, long-term survival and relapse rate of aplastic anemia during follow-up for more than 1 year. Methods : Twenty-eight children, with moderate to severe aplastic anemia were followed for more than one year and 7 children expired after therapy, were analyzed. Antilymphocyte globulin(ALG) or antithymocyte globulin(ATG) by itself was given to 27 patients, and cyclosporine A(CsA)...
Induction Chemotherapy with BH-AC, Idarubicin, and 6-Thioguanine in Childhood Acute Myelogenous Leukemia
Hyo Jeong Han, Hyoung Jin Kang, Jun Ah Lee, Hyoung Soo Choi, Hyeon Jin Park, Ki Woong Seong, Eun Sun Yoo, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1998;41(2):209-215.   Published online February 15, 1998
Purpose : We have undertaken this study to evaluate the effects of induction chemotherapy involving BH-AC, idarubicin, and 6-thioguanine(6-TG). Methods : BH-AC 300mg/m2/day was administered intravenously over three hours for seven consecutive days. Idarubicin 12mg/m2/day was administered intravenously for three days. 6-TG 100 mg/m2/day was administered orally for seven days. Intrathecal ara-C was administered on the first day of treatment. Results...
A Result of Treatment of Malignant Germ Cell Tumors in Childhood
Hyoung Jin Kang, Jun Ah Lee, Hyo Jeong Han, Hyoung Su Choi, Hyeon Jin Park, Ki Woong Sung, Eun Sun Yoo, Hee Young Shin, Hyo Seop Ahn, Kwi Won Park, Byung Keu Cho, Hwang Choi, Chul Woo Kim
Clin Exp Pediatr. 1997;40(12):1707-1718.   Published online December 15, 1997
Purpose : Germ cell tumors have variable clinical characteristics according to the age, sex, primary site, and pathologic diagnosis. To provide the therapeutic principle, the clinical characteristics, response to the treatment, and prognostic factors were analyzed. Methods : Medical records of 57 children who were diagnosed as malignant germ cell tumor in Seoul National University Children' s Hospital from January 1986 till June 1996 were...
Outcome after Treatment of Retinoblastoma
Hyoung Soo Choi, Ki Woong Seong, Jae Kyung Lee, Kyung Ha Yoo, Hee Young Shin, Young Suk Yu, Hyo Seop Ahn
Clin Exp Pediatr. 1997;40(4):519-530.   Published online April 15, 1997
Purpose : Current treatment in retinoblastoma aims to save life and preserve useful vision by using combined modality therapy. This study was performed to determine the outcome after treatment of retinoblastoma. Methods : Medical records of all cases of retinoblastoma seen at Seoul National University Children's Hospital from September 1986 to April 1995 were reviewed. During this period, the treatment method...
Mucormycosis in Leukemic Children
Seung Ghon Nam, Eun Wha Choi, Jin Young Park, Jong Jae Kim, Hee Young Shin, Hoan Jong Lee, Hyo Seop Ahn
Clin Exp Pediatr. 1996;39(3):379-388.   Published online March 15, 1996
Purpose : Mucormycosis is an opportunistic fungal infection caused by one of the ubiquitous fungi of the order Mucorales, occurring almost exclusively in immunocompromised hosts such as patients with diabetes, leukemia and lymphoma. Recently the incidence of mucormycosis is rising associated with the increasing predisposing factors such as cytotoxic drugs and immunosuppressive agents. Though mucormycosis is frequently fatal, there has...
Infections in Children with Neoplastic Disease
Eun Hwa Choi, Jin Won Pyo, Jin Young Park, Kyung Bae Kwon, Bo Young Yun, Hee Young Shin, Hoan Jong Lee, Hyo Seop Ahn
Clin Exp Pediatr. 1995;38(3):366-377.   Published online March 15, 1995
Purpose : Infection is a major complication in patients with malignant disease. This study was performed to identify the causes and the etiologic agents of febrile infections and to characterize the clinical courses including the response to antimicrobial agents inpediatric cancer patients. Methods : This study reviewed 274 febrile episodes occurring in 163 children with neoplastic disease which were indentified prospectively...
Results of Chemotherapy of Hepatoblastoma and Hepatocellular Carcinoma in Children
Kyung Duk Park, Gi Woong Seong, Jae Kyung Lee, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1995;38(2):195-206.   Published online February 15, 1995
Purpose : Surgical excision has been the primary treatment for hepatoblastoma and hepatocellular carcinoma. However, at presentation, only one third of such tumors are surgically resectable. Without operation, the disease is fatal. Therefore, neoadjuvant chemotherapy has been introduced for conversion of the unresectable tumors into the resectable ones. We studied th e effects of chemotherapy for hepatic malignancy in children. Methods...
Antilymphocyte Globulin Therapy for Aplastic Anemia in Children
Soo Jong Hong, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1994;37(11):1526-1539.   Published online November 15, 1994
Immunosuppressive therapy based on the use of antilymphocyte globulin (ALG) has become standard therapy for patients with aplastic anemia who are not eligible for bone marrow transplantation. In this study, T cell subsets before and after ALG therapy, hematologic responses, complications and prognostic factors were analysed. Eleven (42%) out of twenty-six patients treated with ALG showed response, but...
Primary Cutaneous Aspergillosis in Leukemic Children
Jin Young Park, Mee Ran Kim, Hee Young Shin, Hoan Jong Lee, Hyo Seop Ahn, Je Guen Chi
Clin Exp Pediatr. 1994;37(4):520-526.   Published online April 15, 1994
Primary cutaneous aspergillosis is rare. In this report we describe primary skin infection by Aspergillus in 9 children with leukemia. The skin lesion was characterized clinically by erythematous macule and papule associated with pain and itching, followed by a rapid progression to ulcer and central black eschars with raised erythematous border at the site of venipuncture, insertion of intravenous cannula,...
The Effect of Alfacalcidol in the Treatment of Idiopathic Myelofibrosis in Children
Soon Ki Kim, Jeong Hee Kim, Dae Hyun Lim, Jong Woon Choi, Byong Kwan Son, Hyo Seop Ahn
Clin Exp Pediatr. 1994;37(3):339-346.   Published online March 15, 1994
Idiopathic myelofibrosis (IMF), which is characterized by marrow fibrosis, leukoerythroblastic anemia, teardrop poikilocytosis and splenomegaly due to extramedullary hematopoiesis, has known to have no form of therapy. On the ground of the possibility of reversing collagen deposition in IMF using 1, 25-dihydroxycholecalciferol [1, 25(OH)2D3], we report here our observations of 5 patients (M:F = 1:4) with IMF before and after treatment...
A Clinical Study of Childhood Soft Tissue Sarcoma
Hye Lim Jung, Hong Heo Koo, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1993;36(9):1258-1270.   Published online September 15, 1993
Medicine, Seoul, Korea Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea To study the clinical characteristics and treatment results of childhood soft tissue sarcoma, the retrospective study was performed on 67 patients with soft tissue sarcoma, experienced at the Department of Pediatrics, Seoul National University Hospital from January, 1982 to July, 1990. The...
A Prospective Study of Totally Implanted Venous Access System in 19 Children with Cancer
Kyung Duk Park, Eun Sil Dong, Seong Hoon Ha, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn, Seong Eun Jun, Gui Won Park
Clin Exp Pediatr. 1993;36(5):687-692.   Published online May 15, 1993
A totally implanted venous access system was inserted in 19 children with cancer. The devices were utilized for the administration of antineoplastic drug, parenteral fluids, antibiotics, and blood products. Total duration of implantation was 4,046 days for 23 implanted system (range 7-445 days). Complications included cather infection (0.247/100 catheter day), occlusion (0.692/100 catheter days), and dislodgement of needle (0.643/100 catheter...
Case Report
Recurrent Rhinocerebral Mucormycosis - A Case Report
Ho Sung Kim, Jin Young Park, Bo Young Yun, Eun Sil Dong, Hee Young Shin, Hoan Jong Lee, Hyo Seop Ahn, Je Geun Chi, Myung Whun Sung
Clin Exp Pediatr. 1993;36(4):589-595.   Published online April 15, 1993
A case of recurrent rhinocerebral mucormycosis that has occurred during an induction chemotherapy for acute megakaryocytic leukemia in a 10 year-old boy is reported. He had suffered from high fever, proptosis, right eye ball pain and necrotic inflammation of hard palate during the chemotherapy of leukemia. CT scan of the paranasal sinus showed inflammatory change of right ethmoid and maxillary...
Original Article
A Clinical Study of Myelodysplastic Syndrome in Children
Seong Hoon Hah, Hyo Seop Ahn
Clin Exp Pediatr. 1993;36(4):556-567.   Published online April 15, 1993
Myelodysplastic syndrome is a heterogeneous disease complex which is basically a clonal disorder and has characteristics of cytopenia of one or more cell series in peripheral blood and of dyspoiesis of precurosirs in bone marrow. Since the nature of this disease in childhooh is very different from that in adults, retrospective clinical study was performed with 17 confirmed patients who...
Acute Megakaryoblastic Leukemia in Children
Hong Hoe Koo, Sang Kyu Park, Eun Sil Dong, Hye Jung Park, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1993;36(1):9-16.   Published online January 15, 1993
We analyzed the clinical and laboratory features of ten children with acute megakaryoblastic leukemia (M7) and compared the findings with those reported in the literature. The diagnosis was supported by ultrastructural examination of platelet peroxidase or immunophenotyping for glycoprotein Iib/IIIa. Of the ten children, five were girls and five were boys. The median age at diagnosis was 13 months. Two...
Carcinomas in Childhood -A 10-Year Experience in Seoul National University Hospital-
Hong Hoe Koo, Kyung Duk Park, Hye Lim Jung, Sang Kyu Park, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1992;35(10):1369-1376.   Published online October 15, 1992
Carcinomas in childhood differ from those in adults in their frequency, histologic type, and distribution of primary sites. In children, carcinomas are rare and few series have been published containing sufficient mumbers of cases to permit a reliable account of the incidence and survival of children with carcinoma. During a 10-year period, 1982-1991, we observed 40 patients less than 16...
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