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- Original Article
- Neonatology (Perinatology)
- Comparison of minimally invasive surfactant therapy with intubation surfactant administration and extubation for treating preterm infants with respiratory distress syndrome: a randomized clinical trial
- Mohammad Kazem Sabzehei, Behnaz Basiri, Maryam Shokouhi, Sajad Ghahremani, Ali Moradi
- Clin Exp Pediatr. 2022;65(4):188-193. Published online July 28, 2021
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Question: Are the short-term outcomes of minimally invasive surfactant therapy (MIST) relatively superior to those of INtubation, SURfactant administration, and Extubation (INSURE) in preterm infants with respiratory distress syndrome (RDS)?
Finding: MIST could be an appropriate substitution for INSURE in preterm infants with RDS since it reduced hospitalization time and number of side effects.
Meaning: MIST is recommended for surfactant administration for its proven advantages over the INSURE technique.
- Review Article
- Neonatology (Perinatology)
- Surfactant preparations for preterm infants with respiratory distress syndrome: past, present, and future
- Ga Won Jeon
- Clin Exp Pediatr. 2019;62(5):155-161. Published online February 8, 2019
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Following the first successful trial of surfactant replacement therapy for preterm infants with respiratory distress syndrome (RDS) by Fujiwara in 1980, several animal-derived natural surfactants and synthetic surfactants have been developed. Synthetic surfactants were designed to overcome limitations of natural surfactants such as cost, immune reactions, and infections elicited by animal proteins contained in natural surfactants. However, first-generation synthetic surfactants...
- Original Article
- Neonatology (Perinatology)
- Transient intubation for surfactant administration in the treatment of respiratory distress syndrome in extremely premature infants
- Ji Won Koh, Jong-Wan Kim, Young Pyo Chang
- Clin Exp Pediatr. 2018;61(10):315-321. Published online September 16, 2018
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Purpose: To investigate the effectiveness of transient intubation for surfactant administration and extubated to nasal continuous positive pressure (INSURE) for treatment of respiratory distress syndrome (RDS) and to identify the factors associated with INSURE failure in extremely premature infants. Methods: Eighty-four infants with gestational age less than 28 weeks treated with surfactant administration for RDS for 8 years were included. Perinatal...
- Review Article
- Neonatology (Perinatology)
- Update of minimally invasive surfactant therapy
- Gyu-Hong Shim
- Clin Exp Pediatr. 2017;60(9):273-281. Published online September 21, 2017
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To date, preterm infants with respiratory distress syndrome (RDS) after birth have been managed with a combination of endotracheal intubation, surfactant instillation, and mechanical ventilation. It is now recognized that noninvasive ventilation (NIV) such as nasal continuous positive airway pressure (CPAP) in preterm infants is a reasonable alternative to elective intubation after birth. Recently, a meta-analysis of large controlled trials...
- Genetic risk factors associated with respiratory distress syndrome
- Heui Seung Jo
- Clin Exp Pediatr. 2014;57(4):157-163. Published online April 30, 2014
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Respiratory distress syndrome (RDS) among preterm infants is typically due to a quantitative deficiency of pulmonary surfactant. Aside from the degree of prematurity, diverse environmental and genetic factors can affect the development of RDS. The variance of the risk of RDS in various races/ethnicities or monozygotic/dizygotic twins has suggested genetic influences on this disorder. So far, several specific mutations in...
- Original Article
- Clinical findings of severe amniotic fluid aspiration pneumonia and effects of surfactant replacement therapy
- Sang Woo Park, Chun-Soo Kim, Sang-Lak Lee, Tae-Chan Kwon
- Clin Exp Pediatr. 2009;52(4):429-434. Published online April 15, 2009
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Purpose : Severe aspiration of the amniotic fluid is known to cause fatal respiratory distress in neonates. We conducted this study to investigate the clinical findings of severe amniotic fluid aspiration pneumonia (AFAP) in neonates and the effect of pulmonary surfactant replacement therapy (SRT). Methods : Retrospective analysis of medical records was conducted on 28 patients who received ventilator care... -
- The effects of early surfactant treatment and minimal ventilation on prevention of bronchopulmonary dysplasia in respiratory distress syndrome
- Jong Jin Park, Pil Sang Lee, Sang Geel Lee
- Clin Exp Pediatr. 2009;52(1):44-49. Published online January 15, 2009
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Purpose : Early surfactant treatment and minimal ventilation, bronchopulmonary dysplasia needed prolonged oxygen supplement is a problem. This study aimed to report the effects of early surfactant treatment and minimal ventilation on the prevention of bronchopulmonary dysplasia in respiratory distress syndrome. Methods : We retrospectively studied 139 premature newborn infants (gestational age, 36 weeks; birth weight, 1,500 gm) admitted to... -
- Clinical characteristics of severe meconium aspiration syndrome
- Chang Won Choi, Beyong Il Kim, Hyun Ju Lee, Kyoung Eun Joung, Gyu Hong Shim, In Suk Lim, Jin-A Lee, Ee-Kyung Kim, Han-Suk Kim, Jung-Hwan Choi
- Clin Exp Pediatr. 2008;51(7):713-721. Published online July 15, 2008
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Purpose : This study aims to describe the clinical characteristics of severe meconium aspiration syndrome (MAS) which required mechanical ventilation over 48 h and to delineate the progress of respiratory failure and radiographic findings in severe MAS. Methods : Twelve infants admitted to the Neonatal Intensive Care Unit (NICU) of the Seoul National University Bundang Hospital diagnosed with severe MAS from... -
- Effect of surfactant lavage in severe meconium aspiration syndrome
- Soon Min Lee, He Min Kim, Ji Hyun Jeon, Min Soo Park, Kook In Park, Ran Namgung, Chul Lee
- Clin Exp Pediatr. 2008;51(4):367-371. Published online April 15, 2008
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Purpose : The surfactant dysfunction may play an important role in meconium aspiration syndrome (MAS). We aim to evaluate the effect of surfactant lavage in the treatment of term infants with MAS. Methods : The medical records of 15 neonates with severe MAS admitted at Yongdong Severance Hospital from 2005 to 2007 were reviewed and analyzed. Seven infants with severe... -
- Oxygenation index as a respiratory parameter of respiratory distress syndrome in preterm infants
- Ji Hyun Jeon, Ran Namgung, Min Soo Park, Kook In Park, Chul Lee
- Clin Exp Pediatr. 2008;51(2):145-149. Published online February 15, 2008
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Purpose : To examine whether changes of oxygenation index (OI) by postnatal age were different by the number of surfactant administration, and different between subgroups of survival and death. Methods : From January 2005 to June 2006, preterm infants (n=84) diagnosed as respiratory distress syndrome (RDS) and treated with surfactant and ventilator were included. They were divided into two groups: Group... -
- The outcome of surfactant replacement therapy in above nearterm neonates with severe pulmonary disease
- Su-Min Shon, Bo-Young Lee, Chun-Soo Kim, Sang-Lak Lee, Tae-Chan Kwon
- Clin Exp Pediatr. 2007;50(12):1200-1205. Published online December 15, 2007
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Purpose : We performed this study to investigate the outcome of surfactant replacement therapy (SRT) in above nearterm neonates who were required mechanical ventilatory care due to meconium aspiration pneumonia (MAP), respiratory distress syndrome (RDS) or other severe pneumonia (PN). Methods : 48 patients, gestational period ≥36 weeks, who were admitted in NICU of Dongsan Medical Center, Keimyung University between July... -
- Case Report
- A case of acute respiratory distress syndrome treated with surfactant and low dose methylprednisolone
- Bo Yeon Choi, Kyong Mo Kim, Jong Seo Yoon, Joon Sung Lee
- Clin Exp Pediatr. 2006;49(4):455-459. Published online April 15, 2006
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The major pathogenesis of acute respiratory distress syndrome (ARDS) is an inflammatory process that results from a diversity of injuries to the body. Due to the various cytokines and vasoactive peptides released from the endothelium, the vascular permeability is increased; the migration of inflammatory cells and the leakage of plasma proteins then occur and edema develops in the alveolus. There... -
- Original Article
- A Study on the Effects of Early Surfactant Replacement and Gentle Ventilation in the Treatment of Respiratory Distress Syndrome
- Yong Suk Lee, Ji Hye Lee, Sang Geel Lee
- Clin Exp Pediatr. 2005;48(10):1096-1101. Published online October 15, 2005
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Purpose : Recently, early surfactant replacement and tidal volume based gentle ventilation has been a fundamental treatment of respiratory distress syndrome(RDS). The aims of this study were to survey the changes in ventilator care duration and rate of complication in RDS groups. Methods : We performed a retrospective study of 255 newborn infants less than 1,500 g admitted to the... -
- Comparison of Clinical Progress between Single- and Multiple-dose Surfactant Treatment in Neonatal Respiratory Distress Syndrome
- Chang Hee Kil, Ho Sang Jeon, Chong Woo Bae
- Clin Exp Pediatr. 2005;48(10):1090-1095. Published online October 15, 2005
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Purpose : In the case of serious respiratory distress syndrome(RDS) or relapse of clinical appearances after single treatment, we obtained more effective results with multiple-dose surfactant replacement therapy. We carried out this investigation for comparing and observing clinical progress between single-dose(group S) and multiple-dose(group M) pulmonary surfactant treatment group of neonatal RDS. Methods : We investigated 48 neonates who were... -
- Human Surfactant Protein-A(SP-A) Gene Locus Associated with Mycoplasma pneumoniae Pneumonia in Korean Children
- Seung Soo Kim, In Kyu Lee, Jung Ho Ko, Myung Ho Oh, Chong Woo Bae
- Clin Exp Pediatr. 2005;48(4):376-379. Published online April 15, 2005
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Purpose : Mycoplasama pneumoniae is a leading cause of pneumonia and exacerbates other respiratory conditions such as asthma. Surfactant protein A(SP-A) is involved in surfactant physiology and surfactant structure, and plays a major role in innate host defense and inflammatory processes in the lung. In this study, SP-A mediated mycoplasma cidal activity. The candidate-gene approach was used to study the... -
- Surfactant Therapy for Neonatal Respiratory Distress Syndrome : Experience in Korea Over 15 Years
- Chong-Woo Bae, Young-Min Kim
- Clin Exp Pediatr. 2004;47(9):940-948. Published online September 15, 2004
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Purpose : Surfactant replacement therapy in neonates with respiratory distress syndrome(RDS) has been used in Korea since 1990. We undertook a collective study of trials from multi-hospitals to evaluate results of neonates with RDS who were treated with surfactant during the past 15 years in Korea(Period I, P-I, 1990-91; Period II, P-II, 1996; Period-III, P-III; 2002). Methods : There were 60... -
- Association between the Human Surfactant Protein-A(SP-A) Gene Locus and Respiratory Distress Syndrome in Korean Neonates
- Jae Hoon Choe, Myung Ho Oh, Jung Ho Ko, Sun Young Kim, In Kyu Lee, Chong Woo Bae
- Clin Exp Pediatr. 2004;47(7):735-739. Published online July 15, 2004
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Purpose : Respiratory distress syndrome(RDS) is caused by a deficiency of pulmonary surfactant, which is a lipoprotein complex. Both low levels of surfactant protein A(SP-A) and SP-A alleles have been associated with RDS. However, the genes underlying susceptibility to RDS are insufficiently known. The candidate-gene approach was used to study the association between the SP-A gene locus and RDS in... -
- Allele Distribution and Frequency of Human Surfactant Protein-A2 in Korean Neonates
- Nyeon Cheon Kim, Hee Chul Yoon, Jung Su Suk, Jung Ho Ko, Ook Joon Yoo, In Kyu Lee, Myung Ho Oh, Chong Woo Bae
- Clin Exp Pediatr. 2003;46(4):340-344. Published online April 15, 2003
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Purpose : We evaluated allele frequencies and distribution of surfactant protein A2(SP-A2) in Korean neonates in order to estimate the prevalence of RDS, to find out new SP-A alleles, and to establish new steroid therapy. Methods : Genomic DNA was extracted from 71 neonates and served as a template in PCR for genotype analysis. SP-A gene-specific amplications and gene-specific allele determinations... -
- Differential Response of Surfactant Protein-A Genetic Variants to Dexamethasone Treatment
- Eul Soon Kim, In Kyu Lee, Myung Ho Oh, Chong Woo Bae
- Clin Exp Pediatr. 2003;46(4):335-339. Published online April 15, 2003
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Purpose : Surfactant protein A(SP-A) is involved in surfactant physiology and structure, and plays a major role in innate host defense and inflammatory processes in the lung. Steroid therapy is widely used for mothers who threaten to deliver prematurely and also used commonly in the management of preterm infants with chronic lung disease. Two SP-A genes(SP-A1, SP-A2) and several alleles... -
- Allele Distribution and Frequency of Human Surfactant Protein-A1 in Korean Neonates
- Kyung Shin Lee, Young Hee Kim, Jung Su Suk, Jung Ho Ko, Ook Joon Yoo, In Kyu Lee, Myung Ho Oh, Chong Woo Bae
- Clin Exp Pediatr. 2002;45(12):1497-1502. Published online December 15, 2002
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Purpose : We evaluated allele frequencies and distribution of surfactant protein A1(SP-A1) in Korean neonates in order to estimate prevalence of RDS to find out new SP-A alleles, and to establish new steroid therapy. Methods : Genomic DNA was extracted from 100 neonates and served as a template in PCR for genotype analysis. SP-A gene-specific amplications and gene-specific allele determinations were... -
- Effect of Nasal Continuous Positive Airway Pressure after Early Surfactant Therapy in Moderate Respiratory Distress Syndrome
- Eun Ji Kim, Hae Sook Kim, Man Hoe Hur, Sang Geel Lee
- Clin Exp Pediatr. 2002;45(10):1204-1212. Published online October 15, 2002
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Purpose : Early surfactant therapy with either gentle ventilation, high-frequency ventilation or aggressive weaning of mechanical ventilation are principles for the treatment of respiratory distress syndrome(RDS). We studied to determine the accessibility of noninvasive nasal continuous positive airway pressure(CPAP) rather than mechanical ventilation by invasive intubation after early surfactant therapy. Methods : The study group consisted of 14 infants who were born and diagnosed with... -
- A Study of Surface Physical Properties of New Surfactant Using Synthetic Peptides of Surfactant Protein-B
- Chong-Woo Bae, Yong-Mook Choi, Joo Hyun Kang, Sang-Chul Lee, Kil Lyong Kim, Kyung-Soo Hahm
- Clin Exp Pediatr. 2000;43(8):1059-1067. Published online August 15, 2000
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Purpose : To produce a new generation of artificial pulmonary surfactant(PS), surfactant protein (SP)-B from human PSwas isolated, and the amino acid sequences of these proteins were studied. Artificial peptides of human SP-B were synthesized. New artificial PS preparations which were composed of phospholopids and two artificial synthetic SP-B peptides were made, and the surface physical properties of these new PS preparations were tested. Methods... -
- Correlation between Changes of Intrapulmonary Right to Left Shunt and Improvements in Oxygenation after Exogenous Surfactant Administration in Preterm Respiratory Distress Syndrome
- Sei Woo Chung
- Clin Exp Pediatr. 1999;42(10):1373-1380. Published online October 15, 1999
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Purpose : This study was aimed to investigate the relationship between changes in intrapulmonary right to left shunt(QSP/QT) and improvements in oxygenation during the 2-hr study period after Surfactant-TA(S-TA) administration. Methods : Umbilical arterial blood gases and corresponding respiratory indexes of 27 preterm neonates with respiratory distress syndrome were studied. The neonates were separated into group A(n=20) and group B(n=7) according... -
- Clinical Trial of Domestically Developed Bovine Lung Surfactant YY-38 in Neonatal Respiratory Distress Syndrome
- Chul Lee, Jeong Nyun Kim, Min-Soo Park, Moon Sung Park, Shin Won Yoon, Wook Chang, Ran Namgung, Kook In Park, Dong-Gwan Han
- Clin Exp Pediatr. 1999;42(4):472-483. Published online April 15, 1999
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Purpose : We previously reported modified bovine lung surfactant YY-38(NewfactanⓇ) had a low surface tension, good hysteresis, and exhibited good pressure-volume curve in animal experiment (J Korean Pediatr Asso 1997;40:771-85). We performed multicenter clinical trial of NewfactanⓇ in neonatal RDS. Methods : Seventy-seven infants with RDS(GA 31.8¡¾2.9 wks and BW 1,809¡¾592 gm) in 4 NICU were enrolled. After administration of... -
- Effects of Two Different Surfactants on RBC Membrane and Type Ⅱ Alveolar Epithelial Cell in Vitro
- Eun Ae Park, Gyoung Hee Kim
- Clin Exp Pediatr. 1999;42(1):32-39. Published online January 15, 1999
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Purpose : Respiratory distress syndrome(RDS) is a major cause of death in premature babies. For the treatment of RDS, various artificial pulmonary surfactants have been used. The incidence of pulmonary hemorrhage is increased in association with surfactant therapy in extremely low birth weight infants. But the pathogenesis of this increased incidence is not clear. So we conducted this study... -
- Prognostic Factors for Mortality in Neonates with Respiratory Distress Syndrome After Surfactant Replacement Therapy
- Nam Soo Kang, Byung Min Choi, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
- Clin Exp Pediatr. 1998;41(9):1188-1197. Published online September 15, 1998
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Purpose : To evaluate the association between neonatal mortality and the initial response to surfactant replacement therapy, and to examine the correlation between the response type and other prognostic factors. Methods : Sixty-seven neonates with respiratory distress syndrome(RDS) were divided into two groups; group I(n=51) who survived and group II(n=16) who died within the first 28 days of life after one... -
- Erratum
- Perinatal Factors Influencing Clinical Response to Surfactant Replacement Therapy in Neonates with Respiratory Distress Syndrome
- June Dong Park, Beyong Il Kim, Jung-Hwan Choi, Chong Ku Yun
- Clin Exp Pediatr. 1998;41(8):1023-1032. Published online August 15, 1998
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Purpose : Surfactant replacement therapy significantly decreases neonatal complications and mortality in neonates with respiratory distress syndrome(RDS), but clinical responses to the treatment is not consistent. An analysis of the perinatal factors influencing the clinical response to the therapy is important for early detection of high risk and prognosis. The purpose of this study is to analyze the clinical... -
- Original Article
- Preparation and in vitro Physical Activities of Crude Natural Surfactant and Artificial Pulmonary Surfactant Containing Synthetic Peptide and Phospholipid Mixtures
- Joo Hyun Kang, Song Yub Shin, Cheol-Young Maeng, Kil Lyong Kim, Chong-Woo Bae, Kyung-Soo Hahm
- Clin Exp Pediatr. 1998;41(4):472-480. Published online April 15, 1998
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Purpose : In this study, natural pulmonary surfactant was extracted from bovine lung lavage and its surface activity was determined. To investigate the usefulness of synthetic peptides reconstituted with phospholipid as artificial surfactant, truncated peptides from surfactant protein (SP)-B were synthesized and restored the surface tension lowering activities when appropriately recombined with phospholipid. Methods : Crude natural surfactant(CNS) was isolated from lung lavage by centrifugation... -
- Influences of the Intrapulmonary R→L Shunt on PaO2 and PaCO2 after Instillation of Exogenous Pulmonary Surfactant to Premature Neonates with Respiratory Distress Syndrome
- Yoon Hyung Park, Sei Woo Chung, Seung Baik Han, Young Se Kwon, Ji Youn Kim, Woo Sik Cheong, Dae Hyun Lim, Byong Kwan Son
- Clin Exp Pediatr. 1997;40(11):1508-1519. Published online November 15, 1997
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Purpose : We are inclined to analyze the relationship between the intrapulmonary right-to-left shunt and the PaO2/PaCO2 after endotracheal single-dose surfactant instillation to premature neonates with respiratory distress syndrome within 6 hours after birth. Methods : From Jan. 1993 to Jun. 1995, we have conducted a clinical trial of surfactant replacement therapy to the premature neonates with respiratory distress syndrome at the neonatal intensive care unit... -
- A Study of Relation between Stable Microbubble Rating and Surfactant Derivatives(SurfactenⓇ : Phospholipid :, ExosurfⓇ : Dipalmitoyl-Phosphatidyl Choline) Concentration in Vitro
- Myung Ho Oh, Kee Hyuck Kim, Jae Gun Sim, Min Hee Kim
- Clin Exp Pediatr. 1997;40(7):939-944. Published online July 15, 1997
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Purpose : With the recent advent of surfactant replacement therapy, there is an increasing need for a rapid and reliable test to predict respiratory distress syndrome (RDS) immediately before or at birth. There are many investigations and methods for the detection of RDS in prenatal or postnatal period. The stable microbubble rating test (SMR-test) developed by pattle et al. is rapid and simple test... -
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Impact Factor4.2
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6.52022CiteScore92nd percentilePowered by
