Journal of the Korean Pediatric Society 2003;46(4):340-344.
Published online April 15, 2003.
Allele Distribution and Frequency of Human Surfactant Protein-A2 in Korean Neonates
Nyeon Cheon Kim1, Hee Chul Yoon1, Jung Su Suk2, Jung Ho Ko2, Ook Joon Yoo2, In Kyu Lee1, Myung Ho Oh1, Chong Woo Bae3
1Department of Pediatrics, Soonchunhyang University Hospital, Chonan, Korea
2Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea
3Department of Pediatrics, Kyunghee University Hospital, Seoul, Korea
한국 신생아의 폐 표면 활성제 단백-A2(Human SurfactantProtein-A2) 유전자 대립형질의 분포와 빈도
김년천1, 윤희철1, 석정수2, 고정호2, 유욱준2, 이인규1, 오명호1, 배종우3
1순천향대학교 의과대학 소아과학교실
2한국과학기술원 생물과학과
3경희대학교 의과대학 소아과학교실
Correspondence: 
Myung Ho Oh, Email: omh@schch.co.kr
Abstract
Purpose
: We evaluated allele frequencies and distribution of surfactant protein A2(SP-A2) in Korean neonates in order to estimate the prevalence of RDS, to find out new SP-A alleles, and to establish new steroid therapy.
Methods
: Genomic DNA was extracted from 71 neonates and served as a template in PCR for genotype analysis. SP-A gene-specific amplications and gene-specific allele determinations were performed using PCR-cRFLP methods.
Results
: The distribution for the alleles of the SP-A2 gene in the study population was 1A, 1A0, 1A1, 1A2, 1A3, 1A5, 1A6, 1A7, 1A8, 1A9, 1A11, 1A12. The specific frequencies for the alleles of the SP- A2 gene in the study population were : 1A=11.3%, 1A0=38%, 1A1=12.7%, 1A2=9.2%, 1A5=15.5%, 1A7= 2.9%, 1A8=4.9%, 1A9=2.2%, others=3.3%.
Conclusion
: The frequency of 1A0 was higher than the other SP-A2 alleles in Korean neonates. This finding suggests that the prevalence of RDS in Korea may be low compared with other countries. However, this finding also suggests that Korean neonates have a high risk of infection.
Key Words: Surfactant, SP-A2, SP-A2 alleles, RDS, Steroid


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