| Allele Distribution and Frequency of Human Surfactant
Protein-A1 in Korean Neonates |
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Kyung Shin Lee1, Young Hee Kim1, Jung Su Suk2, Jung Ho Ko2, Ook Joon Yoo2, In Kyu Lee1, Myung Ho Oh1, Chong Woo Bae3 |
1Department of Pediatrics, College of Medicine, Soonchunhyang University, Chonan, Korea
2Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea
3Department of Pediatrics, College of Medicine, Kyunghee University, Seoul, Korea |
| 한국 신생아의 폐 표면 활성제 단백-A1(Human Surfactant Protein-A1)유전자 대립형질의 분포와 빈도 |
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이경신1, 김영희1, 석정수2, 고정호2, 유욱준2, 이인규1, 오명호1, 배종우3 |
1순천향대학교 의과대학 소아과학교실
2한국과학기술원 생물과학과
3경희대학교 의과대학 소아과학교실 |
Correspondence:
Myung Ho Oh, Email: omh@schch.co.kr
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| Abstract |
Purpose
: We evaluated allele frequencies and distribution of surfactant protein A1(SP-A1) in Korean neonates in order to estimate prevalence of RDS to find out new SP-A alleles, and to establish new steroid therapy.
Methods
: Genomic DNA was extracted from 100 neonates and served as a template in PCR for genotype analysis. SP-A gene-specific amplications and gene-specific allele determinations were performed using PCR-RFLP methods.
Results
: The distribution for the alleles of the SP-A1 gene in the study population were 6A, 6A2, 6A3, 6A4, 6A8, 6A9, 6A10, 6A11, 6A12, 6A13, 6A14, 6A15, 6A16, 6A17, 6A18, 6A20. The specific frequencies for the alleles of the SP-A1 gene in the study population were : 6A2=21%, 6A3=45%, 6A4=11%, 6A8=9%, 6A14=8%.
Conclusion
: The frequency of 6A3 was higher than the other SP-A1 alleles in Korean neonates. This finding suggests that the prevalence of RDS in Korea may be low compared with other countries. However, this finding also suggests that Korean neonates have a high risk of infection. |
| Key Words:
Surfactant, SP-A1, SP-A1 alleles, RDS, Steroid |
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