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Original Article
Clinical significance of cerebrospinal fluid pleocytosis in pediatric refractory status epilepticus
Jung Mi Kim, Young Mi Kim, Soon Hak Kwon
Clin Exp Pediatr. 2006;49(10):1086-1092.   Published online October 15, 2006
Purpose : Refractory status epilepticus(RSE) is a serious neurological emergency in children. The mortality is high and the neurological outcome is not good. This study aimed to evaluate the clinical significance of cerebrospinal fluid(CSF) pleocytosis in refractory status epilepticus in children. Methods : From January 1999 to January 2006, 25 out of 37 children with refractory status epilepticus had...
Plasma G-CSF and GM-CSF Concentration and Amount of Their Receptors on the Granulocyte in Kawasaki Disease
Young-Kyoung Yoo, Gibum Lee, Hyun-Hee Kim, Soo-Young Kim, You-Jeong Kim, Wonbae Lee
Clin Exp Pediatr. 2003;46(4):376-381.   Published online April 15, 2003
Purpose : This study aimed to demonstrate the possible pathogenesis of granulopoiesis in patients of Kawasaki disease(KD) using quantitative analysis of G-CSF, GM-CSF and their CSFr. Methods : The plasma levels of G-CSF, GM-CSF, G-CSFr and GM-CSFr were studied in 14 patients in the acute phase of KD; 13 children with normal peripheral white blood cell counts were used as the...
Prognostic Value of Repeated Cerebrospinal Latex Agglutination Testing in Bacterial Meningitis
Soo Jeong Lee, So Hyun Ahn, Su Jin Cho, Hae Soon Kim, Seung Joo Lee
Clin Exp Pediatr. 2003;46(4):345-350.   Published online April 15, 2003
Purpose : Bacterial meningitis is a serious infection of childhood associated with a significant morbidity and mortality. Repeated cerebrospinal fluid(CSF) examination is a useful prognostic indicator and a delayed sterilization is associated with a higher incidence of neurologic abnormalities. In this study we tried to determine the prognostic value of repeated CSF latex agglutination testing. Methods : We retrospectively evaluated 19...
Plasma G-CSF and GM-CSF Concentrations and Expression of their Receptors on the Granulocyte in Children with Leukocytosis
Won Seok Choi, Kyung Hwan Ryu, You Jeong Kim, So Young Kim, Hyun Hee Kim, Wonbae Lee
Clin Exp Pediatr. 2003;46(3):271-276.   Published online March 15, 2003
Purpose : Granulocyte-colony stimulating factor(G-CSF) and granulocyte macrophage-colony stimulating factor(GM-CSF) are principal cytokines in granulopoiesis and their physiologic effects are mediated through binding to specific cell surface receptors. Although it is known that the level of serum G-CSF and GM-CSF, and presentation of the receptors are increased in infectious diseases, there have been no studies to find the correlation between...
Serum Level of G-CSF and GM-CSF and CFU-GM Response to Hematopoietic Growth Factors in a Patient with Cyclic Neutropenia
Youn-Kyung Lee, Seok-Hun Kim, Kwang-Woo Kim, Soon Lee, Heung-Sik Kim, Dong-Seok Chun, Kun-Soo Lee
Clin Exp Pediatr. 2001;44(10):1168-1175.   Published online October 15, 2001
Purpose : Serum levels of G-CSF and GM-CSF were measured and CFU-GM assay using G- CSF, GM-CSF and SCF was conducted to evaluate the influence of hematopoietic growth factor on the precursor cells of cyclic neutropenia. Methods : A 7-year-old male with cyclic neutropenia was studied. Marrow mononuclear cells were isolated at neutrophil nadir and recovery and cultured in methylcellulose media...
The Effect of rhG-CSF and rhGM-CSF on Expression of Fcγ Receptors and β2 Integrin and Respiratory Burst Function in Human Granulocytes
Kyung Hyo Kim, Kyung Ha Ryu, Moon Kook Park
Clin Exp Pediatr. 2001;44(4):397-404.   Published online April 15, 2001
Purpose : Receptors for the Fc of IgG(FcγR) and a β2 integrin molecule, CD11c/CD18 are important in clearance of microbes by granulocytes. We performed an in vitro study on the effect of recombinant human granulocyte colony-stimulating factor(rhG-CSF), or granulocyte-macrophage colony-stimulating factor(rhGM-CSF) on the expression of FcγR II, FcγR III, CD11c and CD18 and respiratory burst function of granulocytes. Methods : Peripheral...
Change of Cerebrospinal Fluid Ferritin in Children with Meningitis
Mee Hee Youm, Eun Young Kim, Young Jong Woo, Hyun Ju Park, Chan Jong Kim
Clin Exp Pediatr. 2000;43(8):1068-1073.   Published online August 15, 2000
Purpose : Despite the advent of new and more potent antibiotics, mortality and morbidity rates due to bacterial meningitis remain stagnant. Rapid detection of microorganism and early antibiotics treatment are the most important prognostic factors of bacterial meningitis. For early diagnosis of bacterial meningitis biochemical markers such as lactic dehydrogenase, lactic acid, C-reactive proteia have been measured in cerebrospinal fluid....
Diagnostic Value of Urine Latex Test In Bacterial Meningitis
Seung Min Lee, Eun Ae Park, Seung Joo Lee
Clin Exp Pediatr. 2000;43(1):55-59.   Published online January 15, 2000
Purpose : Bacterial meningitis in childhood carries significant mortality and morbidity, so accurate and rapid diagnosis is important. Cerebrospinal fluid(CSF) latex agglutination test has been used for rapid diagnosis of bacterial meningitis. However, urine may be the best specimen for a latex test, because bacterial antigens are concentrated in the urine. The study tried to determine the diagnostic value of urine latex test in...
Changes of Interleukin-10 and Granulocyte Colony-Stimulating Factor in Cerebrospinal Fluid of Children with Aseptic Meningitis
Byeong Chan Park, Jung-Yeon Shim, Jeong Mi Lee, Jin-Young Park, Myung Ja Yoon, Hye Rim Jung, Moon Soo Park, Dong Hyeuk Keum, Dong Keug Keum
Clin Exp Pediatr. 1999;42(12):1676-1682.   Published online December 15, 1999
Purpose : Interleukin(IL)-10 is an antiinflammatory cytokine produced by monocytes/macrophages. Granulocyte colony-stimulating factor(G-CSF) plays an important role, not only as a hemopoietic factor but also as a regulating factor for a biologic defense system by neutrophils, in the foci of infection. We studied G-CSF and IL-10 levels in the serum and cerebrospinal fluid(CSF) of patients with aseptic meningitis and investigated...
Serum G-CSF Level Changes in Neonatal Sepsis
Kyung Ha Ryu, Eun Ae Park, Kyung Hyo Kim, Gyung Hee Kim
Clin Exp Pediatr. 1998;41(1):12-18.   Published online January 15, 1998
Purpose : The neonate is susceptible to severe and overwhelming bacterial infections. One of the most important deficiency in the neonatal host defense system seems to be quantitative and qualitative deficiency of the myeloid and the phagocytic system. Granulocyte colony-stimulating factor(G-CSF) has been shown to induce neutrophilia and enhance mature effector neutrophil function. We examined serum levels of G-CSF in...
Zinc and Copper Concentrations and Their Correlation with Protien in Cerebrospinal Fluid of Children with Neurologic Disorders
Myung Joon Cha, Young Joon Kim, Ha Joo Choi, Woo Kap Chung
Clin Exp Pediatr. 1997;40(8):1062-1070.   Published online August 15, 1997
Purpose : The importance of trace elements in their effect on the physiology and pathology of the central nervous system is well recognized. Changes in the concentrations of these elements in the brain could take place in pathological states. Recently, a greater emphasis has been given to the role of trace elements in the function of the nervous system both in normal and pathological...
The Variations of CSF Glucose-To-Blood Glucose Ratio according to the Time of Blood Sampling in Asepetic Meningitis
Dong Gui Jang, Yong Seok Choi, Mee Kyoung Lee, Chang Hee Kim, Dong Jin Lee
Clin Exp Pediatr. 1994;37(12):1687-1692.   Published online December 15, 1994
The Measurement of CSF glucose and CSF glucose-to-blood glucose ratio is a very useful laboratory test for the differential diagnosis of meningitis. We have observed the change of blood glucose & CSF glucose-to-blood glucose ratio according to the time of blood sampling in 84 patients with aseptic meningitis who had been admitted to the department of peditrics, Dong Kang hospital...
A Case of Recurrent Bacterial Meningitis with CSF Rhinorrhea.
Dae Shik Kim, Jin Yong Lee, Chang Jun Coe, Jin Suk Suh
Clin Exp Pediatr. 1989;32(8):1161-1166.   Published online August 31, 1989
Recurrent bacterial meningitis is a rare disease which is associated with congenital or acquired anatomical defects of CNS and surround structures, or it may be due to parameningeal foci of infection, defects in immune response, and post-operative state of shunt procedure in hydrocephalus. We experienced the patient of recurrent bacterial meningitis with CSF rhinorrhea due to structural defect which was not defined exactly. We identified...
Cerebrospinal Fluid Lymphocytosis in Acute Bacterial Meningitis on Children.
Hong Kun Kim, Woo Gill Lee
Clin Exp Pediatr. 1988;31(6):707-714.   Published online June 30, 1988
Clinical and laboratory analysis of 78 cases of acute bacterial meningitis diagnosed by cere- brospinal (CSF) culture under 15 years old was made, retrospectively from Jan. 1973 to Dec. 1986, who were admitted to the Department of Pediatrics Hanyang University Hospital. The results analysed were as follows: 1) CSF lymphocytosis (more than 50% lymphocytes or mononuclear cells)occurred in 18 of 78 cases (23%) of bacterial meningitis. 2) There...
Clinical Observation and Study for Cerebrospinal Fluid Protein Levels in Aseptic Meningitis.
D H Chee, M I Lee, S H Kim, K C Sohn
Clin Exp Pediatr. 1987;30(10):1107-1114.   Published online October 31, 1987
Observation for clinical findings and laboratory findings, especially for cerebrosipinal fluid protein level has been done in 57 cases of aseptic meningitis who had been admitted to pediatric dept, of National Medical Center from Jan. ’81 to May ’85. The results were as follows; 1) The ratio of male to female was 1.7:1, and the cases were distributed relatively evenly through ...
Case Report
A Case of Recurrent Bacterial Meningitis Secondary to the Defect of Stapes Footplate.
Soon Hee Eom, Joo Hong Cha, Byoung Soo Cho, Sa Jun Chung, Chang Il Ahn, Chang Il Cha
Clin Exp Pediatr. 1986;29(7):779-783.   Published online July 31, 1986
With the dramatic lowering the mortality rate of bacterial meningitis since the introduction of antibacterial agents, multiple attacks of bacterial meningitis no longer are a curiosity. So multiple attacks of bacterial meningitis may be the only indication of the existence of an abnormal communication between the nasopharynx or ear and the meningeal space and such a communication must be found. We...
A Case of Eosinophilic Granuloma with Recurrent Bacterial Meningitis associated with CSF Rhinorrhea.
Eung Deok Choi, Mee Kyung Namgoong, Seung Ha Yoo, Baek Keun Lim, Jong Soo Kim, Tae Seung Kim
Clin Exp Pediatr. 1986;29(2):209-214.   Published online February 28, 1986
We experienced a case of eosinophilic granuloma with multiple lesions on skull, ribs, vertebrae, tibia and pelvic bone. In addition, recurent bacterial meningitis was associated with CSF rhinorrhea probably due to osteolytic lesion of eosinophilic granuloma in the same patient. A brief review of literature was made.
Original Article
Clinical Study of Cerebrospinal Fluid Lactate Levels in Children with Menigitis.
Sang Hee Cho, Ha Baik Lee, Keun Soo Lee
Clin Exp Pediatr. 1984;27(5):475-482.   Published online May 31, 1984
Cerebrospinal fluid lactate level and C-reactive protein(CRP) reactions were studied in 131 children who were hospitalized to the Department of Pediatrics, Hanyang University Hospital between February 1983 and August 1983. Among 131 hospitalized children, 68 were meningitis cases as for study group and the rest 63 were non-meningitis cases as for control group. These two groups were statistically well matched....
A Study on CSF Enzyme Activity in Central Nervous System Infections.
Kwang Rhyen Koo, Cheol Won Park, Jong Myeon Hong, Yeong Bong Park, Chang Soo Ra
Clin Exp Pediatr. 1983;26(9):884-890.   Published online September 30, 1983
May investigators suggested that The measurement of CSF enzyme activity, especially those of glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT) and lactate dehydrogenase (LDH), are a helpful laboratory test for the diagnosis of CNS infections. 100 patients with epidemic encephalitis (Japanese encephalitis, 7 patients with bacterial meningitis, 6 patients with epilepsy and 11 patients without CNS diseases were subjected to this study. All patients...
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