| Zinc and Copper Concentrations and Their Correlation with Protien in Cerebrospinal Fluid of Children with Neurologic Disorders |
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Myung Joon Cha, , Young Joon Kim, Ha Joo Choi, Woo Kap Chung |
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Department of Pediatrics, College of Medicine, Hallym University, Seoul, Korea |
| 신경성 질환을 가진 소아의 뇌척수액내 아연, 구리 농도 및 이들과 뇌척수액 단백질 농도의 상관관계에 관한 연구 |
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차명준, 반요섭, 김영준, 최하주, 정우갑 |
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한림대학교 의과대학 소아과학교실 |
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| Abstract |
Purpose
: The importance of trace elements in their effect on the physiology and
pathology of the central nervous system is well recognized. Changes in the concentrations
of these elements in the brain could take place in pathological states. Recently, a
greater emphasis has been given to the role of trace elements in the function of the
nervous system both in normal and pathological conditions. The past experiments from
animal demonstrate that Na＋-K＋-ATPase inhibition, particularly in the hippocampus, is
involved in epileptogenicity. Zinc is the most potent inhibitor of Na＋-K＋-ATPase
followed closely by copper. Zinc modulates the activity of glutamic acid decarboxylase,
the rate limiting enzyme in the synthesis of γ-aminobutyric acid(GABA), which is a
major inhibitory neurotransmitter. There are few reports of zinc and copper concentrations
in normal CSF and in CSF from patients with neurological diseases. The aim of
this study was designed to determine the zinc and copper concentrations and their
correlation with protein in CSF of pediatric patients with neurologic disorders.
Methods
: The study population was 43 patients who had admitted to Kang Nam
Sacred Heart Hospital of Hallym University from March to June, 1996 due to high fever,
headache, vomiting, and seizure. All patients were examined CSF study, 32 patients(group
I) were showed abnormal CSF and seizure disorders including febrile convulsion and 11
patients(group II) were showed normal CSF and clinical symptoms of febrile illness. Zinc
and copper concentrations in CSF were determined with flame atomic absorption spectrophotometry.
In addition, CSF zinc and copper concentrations in normal CSF protein group(group A) and in increased CSF protein group(group B) were determined to
investigate probability that the damaged blood-brain-barrier permits the passage of zinc
and copper into the subarachnoid space.
Results
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1) The CSF zinc concentrations in group Ⅰ and Ⅱ were 9.40±6.18 and 7.39±5.48μg/dl,
and the CSF copper concentrations in group Ⅰ and Ⅱ were 4.86±7.07 and 2.93±1.45μg/dl,
respectively. There was no statistically significant difference in the CSF zinc and copper
concentrations between the two groups.
2) The CSF zinc concentrations in group A and B were 7.21±4.96 and 11.24±7.32μg/
dl, and the copper concentrations in group A and B were 3.31±2.15 and 5.59±9.46μg/dl,
respectively. There was no statistically significant difference in the CSF zinc and copper
concentrations between the two groups.
3) There was a significant positive correlation between the CSF zinc and copper
concentrations as well as between the CSF zinc and protein concentrations. But there
was no significant correlation between the CSF copper and protein concentrations.
Conclusions
: There was no statiscally significant defference in the CSF zinc and
copper concentrations between neurologic disorders and febrile diseases. Increased CSF
zinc and copper concentrations in increased CSF protein groups were not found. But
there were some correlation between zinc, copper, protein levels in CSF. These results do
not support assumption that damaged BBB permits the passage of the zinc, copper into
the subarachnoid space. |
| Key Words:
CSF zinc, Copper, Protein concentration |
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