| A Study on CSF Enzyme Activity in Central Nervous System Infections. |
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Kwang Rhyen Koo, Cheol Won Park, Jong Myeon Hong, Yeong Bong Park, Chang Soo Ra |
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Department of Pediatrics，College of Medicine, Chosun University Kwangju, Korea |
| 중추신경계 급성감염에 있어서의 뇌척수액 효소활성도에 관한 고찰
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구광련, 박철원, 홍종면, 박영봉, 라창수 |
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조선대학교 의과대학 부속병원 소아과학교실 |
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| Abstract |
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May investigators suggested that The measurement of CSF enzyme activity, especially
those of glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT)
and lactate dehydrogenase (LDH), are a helpful laboratory test for the diagnosis of CNS
infections. 100 patients with epidemic encephalitis (Japanese encephalitis, 7 patients with
bacterial meningitis, 6 patients with epilepsy and 11 patients without CNS diseases were
subjected to this study. All patients were hospitalized at the Department of Pediatrics,
Chosun University Hospital, during the period of August-October, 1982. Measurements of
GOT, GPT and LDH levels were performed by UV-Kinetic method.
The following results were obtained;
1. GOT levels in the CSF of the patients with epidemic encephalitis were 9.7±6.4 U/L
and were similar to those of the patients with epilepsy (8.1±4.3 U/L) and of the normal
control group (8.2±4.8 U/L). However, in the patients with bacterial meningitis, the levels
of GOT in the CSF (30.1±9.6 U/L) were markedly elevated (p<. 01).
2. GPT levels in the CSF of the patients with epidemic encephalitis, epilepsy and normal
control group were 3.6±3.7 U/L, 3.5±4.8 U/L and 2.0±3.2 U/L respectively. However, in
the patients with bacterial meningitis, the levels of GPT in the CSF (6. 5±3.3 U/L) were
moderately elevated.
3. LDH levels in the CSF of the patients with epidemic encephalitis and epilepsy were
25.2±21.0 U/L and 17.6±5.3 U/L respectively, and these levels were moderately elevated
in compaired with those levels of normal control group (9.6±10.2 U/L). However, in the
patients with, bacterial meningitis, the levels of LDH in the CSF (90.1±55.3 U/L) were
approximately five times as much as those measured in the patients with epidemic encephalitis
(P< 01). The results of authors study suggested that The measurements of CSF transaminase and
LDH levels are an important diagnostic aid for CNS infections.
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| Key Words:
CNS infections, GOT, GPT, LDH, CSF. |
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