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Original Article
The Effectiveness of Intravenous Immunoglobulin for Clinically Suspected Neonatal Sepsis
Hyun Jung Na, Ji Young Kim, Gyeong Hoon Lee, Jun Hwa Lee, Eun Jin Choi, Jin Kyung Kim, Hai Lee Chung, Woo Taek Kim
Clin Exp Pediatr. 2005;48(11):1187-1192.   Published online November 15, 2005
Purpose : The purpose of this study is to determine the effectiveness of intravenous immunoglobuin (IVIG) administration in fullterm neonates having clinically suspected neonatal sepsis. Methods : Forty full-term neonates admitted to the neonatal intensive care unit with clinically suspected neonatal sepsis, who had at least two positive diagnostic criteria were enrolled. Twenty neonates were enrolled into the IVIG arm and...
Case Report
Successful Management with Vincristine after Failure of Prednisolone Therapy for Diffuse Neonatal Hemangiomatosis
Hak-Sung Lee, Soon-Young Heo, Won-Duck Kim
Clin Exp Pediatr. 2005;48(9):1004-1008.   Published online September 15, 2005
Hemangiomas are the most common benign tumors of infancy. Fifteen to 30% of these patients have multiple hemangiomas. Diffuse neonatal hemangiomatosis (DNH) is a disease that often has a fatal outcome if left untreated, and is characterized by multiple cutaneous and visceral hemangiomas. Corticosteroids are the commonly accepted first line treatment, but if no effect is seen, further treatment is...
Original Article
Investigation of Automated Neonatal Hearing Screening for Early Detection of Childhood Hearing Impairment
Jeong Il Seo, Si Uk Yoo, Sung Hyeon Gong, Kwang Su Hwang, Hyeon Jung Lee, Joong Pyo Kim, Hyeon Choi, Bo Young Lee, Ji Sun Mok
Clin Exp Pediatr. 2005;48(7):706-710.   Published online July 15, 2005
Purpose : Early diagnosis of congenital hearing loss through the neonatal hearing screening test minimizes language defect. This research intends to identify frequency of congenital hearing loss in infants through neonatal hearing screening test with the aim of communicating the importance of hearing test for infants. Methods : From May 20, 2003 to May 19, 2004, infants were subjected to Automated...
Reevaluation of the Neonatal Screening Test for Congenital Hypothyroidism
So Young Kang, Young Pyo Chang, Jeesuk Yu
Clin Exp Pediatr. 2005;48(4):387-394.   Published online April 15, 2005
Purpose : We performed this study to compare the TSH and free T4 levels according to gestational age and birth weight, and to reevaluate the cut-off values in the neonatal screening test for congenital hypothyroidism. Methods : Total 2,133 neonates(1,749 healthy newborns and 384 sick neonates) were screened in Dankook University Hospital from May 2000 to January 2003. Neonates with abnormal...
The Association of Neonatal Hyperbilirubinemia with UGT1A1 and CYP1A2 Gene Polymorphism in Korean Neonates
Hoon Kang, Jun Ho Lim, Ji Sook Kim, Eun Ryoung Kim, Sung Do Kim, Hee Jae Lee, Joo Ho Chung
Clin Exp Pediatr. 2005;48(4):380-386.   Published online April 15, 2005
Purpose : The incidence of nonphysiologic neonatal hyperbilirubinemia is twice as high in East Asians as in whites. Recently, UGT1A1 mutation was found to be a risk factor for neonatal hyperbilirubinemia. In congenitally-jaundiced Gunn rats, which lack expression of UDP-glucuronosyltransferase, alternative pathways can be stimulated by inducers of CYP1A1 and CYP1A2 enzymes. CYP1A2 plays a major role in bilirubin degradation...
A Cost-benefit Analysis on Neonatal Screening of Phenylketonuria and Congenital Hypothyroidism in Korea
Hoe Cheol Yoon, Nyeon Cheon Kim, Dong Hwan Lee
Clin Exp Pediatr. 2005;48(4):369-375.   Published online April 15, 2005
Purpose : Many inborn errors of metabolism can be completely cured with early detection and early treatment. This is why neonatal screening on inborn errors of metabolism is implemented worldwide. In this study, a cost-benefit analysis was performed on the neonatal screening of phenylketonuria and congenital hypothyroidism in Korea. Methods : This study included 2,908,231 neonates who took the neonatal screening...
Case Report
A Case of Neonatal Lupus Erythematosus Associated with Anti-U1RNP Antibodies
Byung-Hoon Ahn, Gu Chang Lee, Tae Young Yoon, Mi-Jung Kim
Clin Exp Pediatr. 2005;48(3):342-345.   Published online March 15, 2005
Neonatal lupus erythematosus(NLE) is a distinct subset of lupus characterized by cutaneous findings, cardiac conduction defects, hepatic or hematologic abnormalities. These manifestations are associated with the presence of maternal auto-antibodies such as anti-SSA/Ro, anti-SSB/La, and rarely anti- RNP(U1RNP) antibodies. Cases of U1RNP antibody-positive NLE have somewhat atypical cutaneous manifestation without cardiac or systemic abnormalities. We report a case of cutaneous...
Original Article
Usefulness of the Transcutaneous Bilirubinometer in Neonatal Jaundice
Joo Ran An, Sung Won Park, Hee Chul Lee, Kyung Ah Kim, Sun Young Ko, Yeon Kyung Lee, Son Moon Shin
Clin Exp Pediatr. 2004;47(12):1287-1292.   Published online December 15, 2004
Purpose : To test the usefulness of a new jaundice meter, the JM-103(Minolta/Hill-Rom Air-shields, Japan) which uses a new probe to compensate for different skin pigmentation or thickness, and displayed actual bilirubin level instead of an index number as in the previous model, the JM-102, we compared transcutaneous bilirubin(TCB) with plasma bilirubin(PB) in newborn infants. Methods : TCB was measured on...
A Clinical Study and Sonographic Findings of Neonatal Adrenal Hemorrhage
Ok Yeon Cho, Kyoung Eun Lee, Eun Jung Shim, Do Jun Cho, Dug Ha Kim, Ki Sik Min, Ki Yang Yoo, Kwan Sub Lee
Clin Exp Pediatr. 2004;47(5):535-542.   Published online May 15, 2004
Purpose : This study was performed to present out experience of neonatal adrenal hemorrhage (NAH) and to help diagnosis and management of NAH. Methods : We conducted a retrospective study on 14 neonates diagnosed as NAH from January 1993 to August 2002 at Hallym Medical Center. Their clinical manifestations, risk factors, sonographic findings and progression of NAH were evaluated using...
Polymorphism of UDP-glucuronosyltransferase Gene(UGT1A1) of Neonatal Hyperbilirubinemia in Korea
Ki Woong Hong, Hoon Kang, Soo Kim, Ji Sook Kim, Eun Ryoung Kim, Hee Jae Lee, Sheng-Yu Jin, Joo Ho Chung
Clin Exp Pediatr. 2004;47(1):18-23.   Published online January 15, 2004
Purpose : The incidence of neonatal hyperbilirubinemia is twice as high in East Asians as in whites and its metabolic basis has not been clearly explained. Recently, UDP-glucuronosyltransferase gene (UGT1A1) mutation was found to be a risk factor of neonatal hyperbilirubinemia in Japanese and Taiwanese Chinese. We studied whether neonatal hyperbilirubinemia is associated with mutation of UGT1A1, which is a...
Clinical Characteristics and Prognosis of Neonatal Seizures
Chang Wu Kim, Chang Hwan Jang, Heng Mi Kim, Byung Ho Choe, Soon Hak Kwon
Clin Exp Pediatr. 2003;46(12):1253-1259.   Published online December 15, 2003
Backgroud : Seizures in the neonate are relatively common and their clinical features are different from those in children and adults. The study aimed to provide the clinical profiles of neonatal seizure in our hospital. Methods : A total of 41 newborns with seizures were enrolled in this study over a period of three years. They were evaluated with special reference...
The Effect of Postnatal Dexamethasone Treatment on Hypoxic-Ischemic Brain Injury in Neonatal Rats
Chang Ro Park, Kyung Pil Park, Heng Mi Kim, Yoon Kyung Sohn
Clin Exp Pediatr. 2003;46(10):989-995.   Published online October 15, 2003
Purpose : Dexamethasone is frequently administered to prevent or treat chronic lung disease in human neonates who are also prone to hypoxic-ischemic(HI) insults. Recently, meta-analysis of the follow-up studies reveals a significantly increased odd ratio for the occurrence of cerebral palsy or an abnormal neurologic outcome, and there is conflicting evidence regarding the impact of dexamethasone exposure on HI brain...
Maternal and Neonatal Outcome of Twin Pregnancies after in vitro Fertilization and Embryo Transfer
Kyung-Ah Kim, Uoo-Gyung Min, Jae-Woo Lim, Nu-Lee Jun, Hye-Sung Won, Chung-Hoon Kim, Ellen Ai-Rhan Kim, Pil-Ryang Lee, In-Sik Lee, Ki-Soo Kim, Ahm Kim, Soo-Young Pi
Clin Exp Pediatr. 2003;46(3):224-229.   Published online March 15, 2003
Purpose : To examine various neonatal outcomes and perinatal factors resulting from assisted reproduction compared to that of spontaneous conception. Methods : This is a retrospective study. The control cases were all twins of spontaneous conception born between periods from January 1995 to June 2000. The study cases were identified from twins conceived by assisted reproduction in the same time peried....
Case Report
A Case of Neonatal Tetanus Cured with Neuromuscular Blocking Agent and Ventilatory Support
Hyeon Joo Lee, Ji Young Jeong, Sa Jun Jung, Yong Mook Choi, Chong Woo Bae
Clin Exp Pediatr. 2003;46(2):192-194.   Published online February 15, 2003
A neonate born at 38 gestational weeks was admitted due to generalized tonic-clonic seizure and cyanosis. The neonate was born six days previously at home through normal delivery and the umbilical cord was cut using scissors sterilized in boiling water. The neonate weighed 3,180 g at admission. Physical examination revealed cyanosis, opisthotonus, trismus and reactive muscle spasms. Laboratory exam, brain...
Original Article
Diagnostic Significance of Neonatal Electroencephalography
Byeong Eui Kim, Heung Dong Kim
Clin Exp Pediatr. 2003;46(2):137-142.   Published online February 15, 2003
Purpose : This study was performed to determine the sensitivity of neonatal electroencephalography (EEG) in detecting underlying brain disease, to compare the sensitivity and specificity of EEG with those of brain ultrasonography and to determine the prognostic value of EEG for neonatal neurologic diseases. Methods : Eighty-seven newborn babies were subjected to a electroencephalographic examination for the evaluation of underlying...
Case Report
A Case of Neonatal Atrial Flutter Treated by Propafenone after Fetal Echocardiographic Diagnosis
Kyung Hwa Lee, Chang Woo Ha, Chul Ho Kim, Min Seob Song, Moon Su Sung
Clin Exp Pediatr. 2002;45(7):928-932.   Published online July 15, 2002
Perinatal atrial flutter is a potentially lethal arrhythmia. Management of this disorder is difficult and controversial. Fetal atrial flutter is a serious and life threatening rhythm disorder particulary when it causes hydrops; it may be associated with fetal death or neurological damage. Although the initial episode of flutter may be difficult to control, recurrence of atrial flutter after successful resolution...
Original Article
Prevalence and Risk Factors of Candida Sepsis in Neonatal Intensive Care Unit
Ic Sun Choi, Suk Hwan Lim, Chang Yee Cho, Young Youn Choi, Tai Ju Hwang
Clin Exp Pediatr. 2002;45(7):836-846.   Published online July 15, 2002
Purpose : With the development of neonatal intensive care and the increased use of systemic antibiotics, candida sepsis has become one of the most important causes of neonatal morbidity and mortality. The purpose of this study was to investigate the prevalence rate and its associated risk factors. Methods : We retrospectively reviewed medical records of 28 cases with candida sepsis who...
Case Report
A Case of Incontinentia Pigmenti with Developmental Brain Malformation
Suk Ho Kang, Soon Kim, Seung Hee Jung, Sang Geel Lee
Clin Exp Pediatr. 2002;45(4):535-539.   Published online April 15, 2002
Incontinentia pigmenti is a rare neurocutaneous syndrome characterized by vesiculobullous skin disease in neonates and infants, a noninfectious disease that should be distinguished from infectious diseases with the neonatal seizure or encephalopathy. This disease is X-linked dominant with Xq28 region abnormalities and often associated with developmental defects of the ocular, skeletal, dental, and central nervous system. Central nervous system involvement...
Original Article
Therapeutic Effect of Different Doses of Recombinant Human Granulocyte Colony-Stimulating Factor(rhG-CSF) on Neonatal Sepsis Complicated by Neutropenia
Moon Young Choi, Yeon Sook Jung, Dong Woo Son, Hyo Seop Ahn
Clin Exp Pediatr. 2002;45(4):439-448.   Published online April 15, 2002
Purpose : The aim of this study is to determine and compare the effects of adjunctive therapy with different doses of recombinant human granulocyte-colony stimulating factor(rhG-CSF) on reversing sepsis-associated neonatal neutropenia, and their survival rate in a group I/II-type trial. Methods : RhG-CSF was injected subcutaneously to 10 septic-neutropenic neonates with doses of 10 μg/kg from Oct. 1995 to Sep. 1996,...
A Nationwide Survey on the Causative Organisms of Neonatal Sepsis in Korea
Kyung Ah Kim, Son Moon Shin, Jung Hwan Choi
Clin Exp Pediatr. 2002;45(1):55-63.   Published online January 15, 2002
Purpose : A nationwide survey was conducted to investigate the most common causative organisms in neonatal sepsis in Korea. Methods : By reviewing medical records of newborn infants who were confirmed as neonatal sepsis by isolating organisms from blood culture during a one year study period from January to December in 1997, data for causative organisms, risk factors, accompanying focal infections and combinations of antibiotics...
Case Report
A Case of Neonatal Alloimmune Thrombocytopenia Related to HLA Antibody
Mi Seon Lee, Hyeon-Soo Lee, Hyun Ok Kim
Clin Exp Pediatr. 2001;44(12):1454-1458.   Published online December 15, 2001
Neonatal alloimmune thrombocytopenia(NAIT) is a very rare disease caused by maternal alloantibodies` response to neonatal platelet antigens. Because the most common cause of NAIT is incompatibility for platelet-specific antigens, NAIT cases due to anti-HLA antibodies are very exceptional. The patient was a second born female. She had no petechia or purpura at birth. But her platelet count was 55,000/mm3 and...
Original Article
The Effect of Tumor Necrosis Factor-α in Cultured Neonatal Rat Cardiomyocytes
Su Jin Kim, Dong Seok Lee, Ok Ko, Il Soo Mun, Bok Hyun Ko, Yong Wook Jung
Clin Exp Pediatr. 2001;44(11):1262-1268.   Published online November 15, 2001
Purpose : Tumor necrosis factor-α(TNF-α) is a pro-inflammatory cytokine that has been implicated in the pathogenesis of cardiovascular disease. Serum levels of TNF-α are elevated in many human cardiac related pathogenic conditions, including heart failure. It is well known that TNF-α inhibits myocardial contractility and induces apoptosis of adult rat cardiomyocytes via stimulation of TNF receptor 1. But pathophysiologically relevant...
Case Report
A Case of Neonatal Urinary Ascites due to Bladder Perforation Treated with Urinary Drainage
Heng-Mi Kim, Su-Hee Kwak, Sung-Kwang Jung, Sang-Kwon Lee
Clin Exp Pediatr. 2001;44(8):948-953.   Published online August 15, 2001
Urinary ascites in newborns is a rare event that usually is associated with posterior urethral valves and other obstructing anomalies of the genitourinary tract. A case of neonatal urinary ascites without genitourinary tract abnormalities is reported. This premature male neonate was treated by artificial ventilation due to respiratory distress syndrome. The umbilical artery catheter was placed without difficulties and functioned...
Original Article
Effect of Parenteral Nutrition Guideline Changes on Neonatal Sepsis in Premature Infants
Chang-Ryul Kim, Jae-Won Oh, Myung-Kul Yum, Soo-Jee Moon
Clin Exp Pediatr. 2001;44(6):620-626.   Published online June 15, 2001
Purpose : We hypothesized that decreased parenteral nutrition would lower the incidence of neonatal sepsis in premature infants. Methods : The study involves 223 premature infants who were admitted to the neonatal intensive care unit of Hanyang University Kuri Hospital from July 1995 to January 1999. Infants were divided into two groups based on different parenteral nutrition guidelines : Old...
Effect of Granulocyte-macrophage Colony-stimulating Factor in Neonatal Infection
Il-Young Jo, Sang-Hyun Byun
Clin Exp Pediatr. 2000;43(12):1552-1557.   Published online December 15, 2000
Purpose : Neutrophils are central to the defences against bacterial infection, and in neonates the number of neutrophils are decreased due to inhibited production and phagocytic function. This induces high mortality rates in infants suffering from neonatal sepsis. Exogenous GM-CSF can increase the number of neutrophils and improve the phagocytic function. To establish the most cost effective dose of exogenous...
Risk Factors for Neonatal Sepsis in Premature Infants Admitted to Neonatal Intensive Care Unit
Chang-Ryul Kim, Jae-Won Oh, Myung-Kul Yum, Soo-Jee Moon
Clin Exp Pediatr. 2000;43(9):1174-1179.   Published online September 15, 2000
Purpose : The purpose of this study is to find out the risk factors of sepsis except the prematurity itself. Methods : Seventy-seven premature infants less than 37 weeks of gestation, who were admitted to the neonatal intensive care unit of Hanyang University Kuri Hospital between July 1995 and December 1996, were enrolled in this study. All 77 premature infants, 14...
Neonatal Systemic Candidiasis : Comparison of Albicans and Parapsilosis Infection
Jung Mie Han, Ho Young Lee, Mi Jeong Kang, Sun Young Ko, Yun Sil Chang, Won Soon Park
Clin Exp Pediatr. 2000;43(8):1052-1058.   Published online August 15, 2000
Purpose : Systemic Candidiasis has become an increasingly important cause of morbidity and mortality in NICU infants. Severe infections caused by non-albicans Candida species have been increasingly reported in NICU infants. The purpose of the present study was to compare relative severity, mortality rates for C. albicans(CA) and C. parapsilosis(CP) infections in our NICU. Methods : This study included 16 infants...
Case Report
A Case of Neonatal Alloimmune Thrombocytopenia due to Anti-HLA A2
Sung Young Kim, Eun Ryoung Kim, Young Jin Kim, Myoung Hee Park, Eun Young Song, Kyou Sup Han
Clin Exp Pediatr. 2000;43(6):861-865.   Published online June 15, 2000
Neonatal alloimmune thrombocytopenia(NAIT) is a rare disease caused by maternal alloimmunization against fetal platelet surface antigen, which is mainly platelet specific alloantigen or human leukocyte antigen(HLA). During routine hemotology, we accidentally discovered thrombocytopenia in a female fullterm newborn admitted due to jaundice. We excluded NAIT due to human platelet alloantigen(HPA), because the HPA of the mother and baby were the...
Original Article
Factors Related to the Outcome of Neonatal Seizures
Sung Koo Kim, Ran Lee, In Kyu Lee, Ki Joong Kim, Young Seung Hwang
Clin Exp Pediatr. 2000;43(2):267-273.   Published online February 15, 2000
Purpose : Seizures during the neonatal period may be an important indicator of serious neurologic abnormalities and can cause permanent neurologic sequelae. We attempted to find and analyze the factors related to the outcome of neonatal seizures. Methods : Seventy-six newborns with seizure were reviewed. The outcomes were analyzed according to etiologic diseases, gestational ages, characteristics of seizure, and neuroimaging and...
Clinical and Molecular-epidemiologic Analysis of A Nosocomial Outbreak of Acinetobacter baumannii in a Neonatal Intensive Care Unit
Hye Kyung Lee, Han Jin Kim, Young Chang Kim, Sung Ran Cho, Hwi Jun Kim, Wee Gyo Lee
Clin Exp Pediatr. 2000;43(1):43-48.   Published online January 15, 2000
Purpose : Acinetobacter species are aerobic gram-negative rods that can be widely found in nature and are a part of the normal flora of humans. The most clinical isolates of A. baumannii reflect infection rather than colonization. Recent reports suggest that the organisms cause serious and often fetal nosocomial infection such as ventilator-associated pneumonia. Methods : From March to September 1998, we experienced thirty...
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