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Case Report
MRI Finding of a Case of Relapsed Acute Mixed Type Leukemia with Bone Marrow Necrosis
Joo Young Park, Euk Park, Seat Byeoul Park, Dong Seok Jeon, Hee Jung Lee, Heung Sik Kim, Chin Moo Kang
Clin Exp Pediatr. 2002;45(2):256-260.   Published online February 15, 2002
Bone marrow necrosis is a rare complication of a variety of diseases affecting the marrow. The cause and incidence are unknown, and reports of treatment response are rare. We describe a case of relapsed acute mixed type leukemia with bone marrow necrosis. The patient was a 10 year old female diagnosed with acute mixed type leukemia four years ago. She...
A Case of Disseminated Lymphangiomatosis Involving Mediastinum, Bone, Spleen and Retroperitoneum in an Asymptomatic Healthy Child
Kyung Hee Yoon, Seung Ju Ha, In Sook Park, Hyun Woo Goo, Jong Hyun Yoon
Clin Exp Pediatr. 2001;44(11):1326-1329.   Published online November 15, 2001
Lymphangiomatosis, a benign tumor consisting of a cluster of dilated lymphatic channels, is very unusual. Most lymphangiomatoses are found in the neck and head area. Less than 5% are diagnosed intraabdominally and they are very infrequently encountered in the retroperitoneal area. Herein, we report a rare case of asymptomatic lymphangiomatosis of a 13 year-old boy during a routine chest...
Langerhans` Cell Histiocytosis Associated wjth Secondary Aneurysmal Bone Cyst, One Case Report
Yong-Koo Park, Kyung Nam Ryu, Won Leem
Clin Exp Pediatr. 2000;43(12):1626-1629.   Published online December 15, 2000
Seconnday aneurysmal bone cyst is the disease that occurrs in the primary bone tumor and/or tumorus conditions Meticulous search is needed to make a correct diagnosis which dose not overlook the primary diseases. We have experinced an osteolytic lesion on the 7-year-old boy on his skull bone. Plain radiography of the skull revealed osteolytic lesion in the parieto-occipital bone. On...
Original Article
Clinical Manifestation of Childhood Acute Leukemia with Bone Involvement
Kyoung Eun Jeong, Hee Jung Lee, Kwang Soon Song, Heung Sik Kim, Chin Moo Kang
Clin Exp Pediatr. 2000;43(6):806-813.   Published online June 15, 2000
Purpose : Bone involvement is known to develop in 40-70% of pediatric acute leukemia. We aimed to analyze the clinical course and result of therapy in pediatric acute leukemia with bone involvement. Methods : Twenty-seven patients diagnosed as pediatric acute leukemia at Dong San Medical Center from Jan. 1996 to Aug. 1998 were evaluated. According to bone X-ray and whole body...
Effect of Antiepileptic Drugs on Bone Metabolism and Growth in Epileptic Children
Woo Suk Juhng, Sun Jun Kim, Soo Chul Cho, Chan Uhng Joo
Clin Exp Pediatr. 1999;42(8):1078-1085.   Published online August 15, 1999
Purpose : Long-term administration of anticonvulsants for children with convulsive disorder may cause osteomalacia, depending on dosage, duration, types, and combination of anticonvulsants administered. This study was performed to examine the effect of anticonvulsant drugs on bone mineral density in epileptic children. Methods : Forty-eight epileptic children aged 3 to 15 years were enrolled in this study. They were treated with...
Effects of Growth Hormone Treatment on Alterations of Growth and Bone Metabolism in Rats Induced by Dexamethasone Administration
Woo Yeong Chung, Jeong Nyu Lee, Hye Kyoung Yoon
Clin Exp Pediatr. 1999;42(7):991-1002.   Published online July 15, 1999
Purpose : The aim of this study was to investigate the alterations of growth and bone metabolism in SDR induced by dexa administration and to evaluate the effects of GH treatment in dexamethasone(dexa) induced growth and bone metabolism in SDR. Methods : Forty-five female Sprague-Dawley rats(weight 150-170gm) were divided in 3 groups: Group 1(n=15) received normal saline as control, Group 2(n=15)...
Bone Mineral Metabolism and Rickets Compared between Fortified Human Milk and Preterm Formula Feeding in Prematurity
Hong Sun Ju, Eun Young Jeong, Seong Sook Jeon, Son Sang Seo
Clin Exp Pediatr. 1998;41(11):1476-1483.   Published online November 15, 1998
Purpose : To compare the effect of breast milk containing fortifier with preterm formula on bone mineral metabolism in premature infants, we evaluated the state of bone mineralization, biochemical alteration and the frequency of rickets during the first five months of life. Methods : Fourteen fortified breast milk-fed infants and eleven preterm formula-fed infants who were born at Il-Sin...
The Effect of Steroid Therapy on Growth and Bone Density in Children with Nephrotic Syndrome
Seong Hoi Jeon, Ae Yeon Lim, Young Kook Kim, Hae Won Cheon, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 1998;41(10):1396-1402.   Published online October 15, 1998
Purpose : Long-term steroid therapy for various glomerular disorders in children has been known to decrease serum Vit D3 level and develop osteomalacia. The aim of this study was to observe the effect of long-term steroid therapy on growth and bone density in children with nephrotic syndrome. Methods : Bone density of 17 steroid-treated nephrotic syndrome was compared with that of...
The Relationships of Pretreatment IGF-I SDS, Delay in Bone Age and Response to Recombinant Human Growth Hormone(rhGH) Therapy in Children with Growth Hormone Deficiency
Seon-Young You, Ki-Joong Kim, Jeh-Hoon Shin, Jin-Nyoung Park, Hee-Jeong Ahn, Yong-Joo Kim
Clin Exp Pediatr. 1998;41(1):90-98.   Published online January 15, 1998
Purpose : To assess whether pretreatment IGF-I SDS and pretreatmental bone age are useful indicators in the response of rhGH therapy in children with GH deficiency(GHD), the relationship between pretreatment IGF-I SDS, delay in bone age and the growth response during the first year of rhGH treatment was analyzed. Methods : This study included 12 children with GHD. We measured IGF-I levels by RIA...
The Changes of the Bone Mineral Density in the Girls with Turner Syndrome, using Recombinant Human Growth Hormone
Sei Won Yang
Clin Exp Pediatr. 1996;39(6):839-845.   Published online June 15, 1996
Purpose : Estrogen deficiency causes sexual infantilism in Turner syndrome, which could decrease the bone mineral density(BMD) since birth. This decreased BMD might be contributed by the decreased growth hormone(GH) secretion. To improve the decreased BMD, estrogen therapy is recommended, especially after the pubertal age, but estrogen therpay during childhood can accelerate the epiphyseal fusion, resulting in shorter final height. There is...
Effect of Steroid Therapy on Bone Mineral Density in Children with Minimal Change Nephrotic Syndrome
Byeong Hee Son, Woo Yeong Chung, Chul Ho Kim
Clin Exp Pediatr. 1996;39(6):822-828.   Published online June 15, 1996
Purpose : Osteoporosis and growth failure have been known one of the serious side effects of corticosteroid therapy especially in children. This study was designed to evaluate the effect of long-term administration of steroids on bone mineral density(BMD) in children with nephrotic syndrome and its relationship to cumulative steroid dose, the duration of the rapy and sex. Methods : The BMD of...
Case Report
A Case of Acute Viral Myositis
Jong-Hoon Kwak, Kyung-Yil Lee, Ji-Whan Han, Sung-Soo Hwang, Jae-Kyun Huh, Kyong-Su Lee
Clin Exp Pediatr. 1996;39(4):572-576.   Published online April 15, 1996
Diffuse myalgia is common in transient systemic viral infections but overt myositis, with weakness and signs of muscle inflammation, rarely accompanies viral infection in chidren. We describe a 8-year-old boy with severe myalgia and tenderness in both lower extremities, whose unusual skeletal muscle uptake on Technetium-methylene diphosphate bone scan helped to diagnosis of myositis. Clinical course, muscle-derived enzyme studies(AST, ALT,...
Original Article
A Study of Bone Marrow Density in Korean Children of Normal Growth and Development
Byung Yoen Kim, Young Guk Kim, Young Jun Kim, Kee Hwan Yoo, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 1995;38(5):612-618.   Published online May 15, 1995
Bone mineral densitometry is a useful procedure for the early detection of metabolic bone diseases and bone density changes caused by long term drug use. Dual energy X-ray absorpt- iometry(DEXA), a recently developed diagnostic radiologic method for evaluating bone mineral density is widely used because of its high sensitivity, easily obtaine results. and low dose radi- ation exposure. The study...
Clinical Studies of Metabolic Bone Disease of Prematurity
Seung-Yeon Suh, Eun-Kyung Lee, Ran Namgung, Hae-Jung Joo, Min-Soo Park, Kook-In Park, Chul Lee, Dong-Gwan Han, Meung-Jun Kim, Jin-Suk Suh
Clin Exp Pediatr. 1995;38(2):159-169.   Published online February 15, 1995
Purpose : Preterm formula used in Korea, theoretically does not supply the recommended mineral intake for optimal bone metabolism in very low birth weight infants(Formula 500-700 mg Ca/L, 300~370mg P/L, and 440IU of vitamin D/L). The purpose of this study is to identify th e possible etiologic factors and clinical course of rickets in these infants. Methods : We recently identified...
The Effect of Long-term Phenobarbital Administration on the Bone Mineral Density of Children
Yoon Suck Suh, Young Guk Kim, Jung Hwa Lee, Kee Hwan Yoo, Joo Won Lee, Young Chang Tockgo
Clin Exp Pediatr. 1994;37(3):368-375.   Published online March 15, 1994
The long term administration of anti-convulsants on children with convulsive disorders may cause osteomalacia, depending on the dosage, duration, type and combination of anti-convulsants administred. Fifteen children, comprising 10 male and 5 female, dignosed with convulsive disorders and administered with phenobarbital for a long term period of more than 9 months but less than 84 months and 15 healthy children...
Treatment of Aplastic Anemia
Nak Gyun Chung, Kyu Jin Bhang, Woo Gun Choi, Hack Ki Kim, Kyong Su Lee, Man Kyu Yang
Clin Exp Pediatr. 1993;36(8):1059-1066.   Published online August 15, 1993
We performed this study to evaluate the therapeutic responses of bone marrow transplantation and immunosuppressive therapy for aplastic anemia in 103 cases(68 severe and 35 moderate). Among them, 15 cases with severe aplastic anemia having HLA-identical sibling donor underwent bone marrow transplantation, and cases (53 severe and 35 moderate cases) without available HLA-identical sibling donor had received immunosuppressive therapy using...
Case Report
Three Cases of Brain Tumors with Bone Metastasis
Eun Joo Kim, Kyung Duk Park, Eun Sil Dong, Hye Jung Park, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn, Je Geun Chi
Clin Exp Pediatr. 1992;35(3):381-389.   Published online March 15, 1992
Medulloblastoma and primitive neuroectodermal tumor(PNET) are relatively common intracranial neoplasms in childhood. Their extracranial metastasis were thought to be rare occurrences. But they are more frequent compared to other intracranial tumors. The most frequent site of metastasis deposits in medulloblastoma is bone, and metastasis to lymph node, peritoneum, liver or lung have been reported infrequently. The authors experienced three cases...
Non-Hodgkin's Lymphoma of Bone with Multiple Punched-out Lesion on Simple Radiologic Examination
Gye Eun Whoang, Sang Hyun Byun, Jong Jin Seo, Keon Su Rhee, Young Hun Chung, Kwang Seon Seo, Cheol Woo Kim, Seong Hoae Kim
Clin Exp Pediatr. 1992;35(2):269-274.   Published online February 15, 1992
NHL is a malignant tumor that invade in abdominal cavity, mediastinum, cervical lymph node, rarely in peripheral lymph node, skin, and bone. Primary malignant lymphoma of bone with multiple punched-out lesion on simple radiologic examination was not reproted yet. We experienced a case of primary NHL of bone with multiple punched-out lesion on simple radiologic examination, in a 3-year 7-month old boy...
Original Article
A case of bone marrow necrosis in acute lymphoblastic leukemia.
Mee Ran Kim, Hye Lim Jung, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1991;34(8):1163-1168.   Published online August 31, 1991
Bone marrow necrosis is a rare complication most commonly encountered in patients with leuke- mia, metastatic tumor in marrow, sickle cell disease, DIC and severe infections. Recently it is regarded as a more common finding frequently overlooked and carrying not so poor prognosis. We reported here a boy with ALL who showed marrow necrosis on biopsy at the time of diagnosis and achieved complete...
Treatment of severe aplastic anemia: comparison between bone marrow transplantation and immunomodulation.
Dae Chul Jeong, Sung Dong Choi, Woo Gun Choi, Hack Ki Kim, Kyong Su Lee, Du Bong Lee
Clin Exp Pediatr. 1991;34(2):172-179.   Published online February 28, 1991
Twenty, six children younger than 15 years with severe aplastic anemia underwent either bone marrow transplantation or immunomodulation therapy (antilymphocyte globulin with cyclosporin A therapy). Six patients who had an HLA-identical sibling donor underwent bone marrow transplantation after conditioning with cyclophosphamide, procarbazine and antilymphocyte globulin. Twenty children who did not have an HLA-identical donor recieved antilymphocyte globulin and cyclosporin A. The results were as follows; 1) Hematologic responses:...
Bone Age Determination and Hand Radiographic Findings in Children With Russell-Silver Syndrome.
Hun Kyu Lim, Sei Won Yang, Hyung Ro Moon
Clin Exp Pediatr. 1989;32(6):823-833.   Published online June 30, 1989
Russell.Silver syndrome is a disease of unknown etiology characterized by prenatal onset dwarfism irrespective of full term gestation, growth retardation, body asymmetry, craniofacial dysproportion with a triangular face, short and incurved little finger, etc. Forty.two children were diagnosed as Russell.Silver syndrome by Silver’s criteria at SNU Children' s Hospital from Apr. 1981 till Aug. 1988, and we reviewed clinical data and hand radiographs of...
The Two Cases of Klippel-Trenaunay Weber Syndrome.
Man Chul Ha, In Hun Lee, Yong Tak Lim, Hi Joo Chun, Hi Ju Park, Chan Yung Kim
Clin Exp Pediatr. 1988;31(3):391-397.   Published online March 31, 1988
We experienced two cases of Klippel-Trenaunay-Weber Syndrome in 13 years old boy and 10 years old girl. They had shown large nevus flammeus, varicose veins, soft tissue and bong hypatrophy. In angrogam and venogram capillary and venous hemangioma were noted, but we could not find arteriovenous filstula. We report two cases of Klippel-Trenaunay-Weber Syndrome with review of literature.
Bone Marrow Cell Culture(GM-CFU) in Anaplastic Anemia of Children.
Jae Sun Jung, Chang Yee Hong
Clin Exp Pediatr. 1985;28(9):888-898.   Published online September 30, 1985
Bone marrow cell cultures (GM-CFU) were performed in the 15 cases of children with aplastic anemia and the correlation with the clinical course were investigated. They have been treated with androgen with or without low dose prednisone and supportive care. Bone marrow cell cultures from 8 children without any evidence of aplastic anemia were performed as a control. 1)In control...
Case Report
A Case of Acute Lymphocytic Leukemia Successfully Treated with Allogeneic Bone Marrow Transplantaion.
In Kyung Sung, Byung Churl Lee, Kyong Su Lee, Du Bong Lee, Chong Won Park, Chun Choo Kim, Dong Jip Kim
Clin Exp Pediatr. 1985;28(8):805-811.   Published online August 31, 1985
A 8-year old boy with acute lymphocytic leukemia who had shown resistance to repeated combination chemotherapies, was successfully grafted with bone marrow from his HLA- matched sister. He was in the third partial remission at the time of bone marrow transplantation. He was conditioned with cyclophosphamide 60 mg/kg/day on two consecutive days, followed by 800 rads total body irradiation. Marrow...
Fanconi's Anemia.
J H Yoo, E M Kim, S J Lee, W B Kim, D W Lee, D Y Kang, K Y choi
Clin Exp Pediatr. 1983;26(11):1139-1144.   Published online November 30, 1983
We report 1 case of Fanconi’s anemia which has severe pancytopenia, increased fetal Hb, hyperpigmented skin, absence of right thumb and metacarpal bone, retardation of bone age and chromosomal abnormalities with a brief review of related literature and references.
Original Article
Statistical Analysis of 1,349 Cases of In-Patients with Various Tuberculosis in Korea.
Jin Woo Hahn, Jae Hoon Shin, Woo Gill Lee
Clin Exp Pediatr. 1983;26(8):778-785.   Published online August 31, 1983
We studied retrospectively the charts of 1,162 in-patients (that is 1,349 lesions) under 20 years of age who were hospitalized with various tuberculosis in Hanyang University Hospital from May 1972 to December 198L The results of the observation are as follows: 1. Annual distribution of 1,162 patients with tuberculosis revealed little fluctuation over the years. 2. The age and sex distribution of tuberculosis is as follows: The...
A Clinical Study of The Bone and Joint Tuberculosis in Childrens.
Byung Hwa Park, Jung Tae Kim, Byung Ryoung Lee, Tae Ju Hwang, Hyung Suk Byun, Chull Sohn
Clin Exp Pediatr. 1982;25(11):1141-1149.   Published online November 30, 1982
.The following results were obtained through the clinical review of 153 cases of bone and joint tuberculosis which were treated at Mokpo Children’s T.B. Hospital during the period of 10 years from Jaunary 1971 till December 1980. 1. The bone and joint tuberculosis was 10.3% of total tuberculous children during the above period. 2. The peak incidence was noted in the group aged 1 〜3 years and...
Allogenic bone marrow transplantation in rabbit.
Kir Young Kim, Duk Hee Kim, Young Mo Shon, Kwan Sub Chung, Hong Jin Kim, Duk Jin Yun
Clin Exp Pediatr. 1982;25(9):867-879.   Published online September 30, 1982
Allogenic bone marrow transplantation was done with Korean unspecified rabbits. Fresh bone marrow cell of different sex was infused to the recipient. The study group was divid- edfive groups according to immunosuppresive drugs. Each group was consited of 20 rebbits, was exposed to 1200 Rad. Group A, which were not have bone marrow transplantation, showed 100% mortality rate after 8 weeks. Group 8, which did not...
Case Report
Fanconi's Anemia.
Seung Kwon Kim, Heung Kyu Kim, Kew Taek Kim
Clin Exp Pediatr. 1981;24(8):782-785.   Published online August 15, 1981
We report 1 case of Fanconi's anemia which has severe pancytopenia, PDA, hypoplatic right thumb and cryptorchism with a brief review of related literature and references.
Original Article
Effect of the Glucocorticoids on the Vertebral Bone Density in Children with the Nephrotic Syndrome
Jong Young Kim, Yong Hoon Park
Clin Exp Pediatr. 1955;38(7):946-954.
Purpose : This study was conducted to evaluate that long term glucocorticoid treatment in children with the nephrotic syndrome can produce a significant loss of bone mass by measuring of bone mineral density(BMD) Methods : We measured BMD at lumbar vertebra(L2-L4) using dual enegy X-ray absorptiom-etry in 36 patients with the nephrotic syndrome who were administered prednisolone over 6 months and...
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