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Case Report
A Case of Relapsed Acute Promyleocytic Leukemia Induced Remission with Arsenic Trioxide(As2O3)
Jin Hye Park, Heung Sik Kim, Chin Moo Kang
Clin Exp Pediatr. 2000;43(8):1132-1136.   Published online August 15, 2000
Acute promyelocytic leukemia(APL) is a unique entity in the spectrum of acute myelogenous leukemia. It has several characteristic features, including distinctive morphology, chromosomal translocation, t(15:17), disseminated intravascular coagulation and effect on retinoic acid. Retinoic acid which is a derivative of vitamin A induces differentation of APL cells in vitro and in vivo, but its cessation induces relapse of APL. Arsenic...
Two Cases of Left Ventricular Tumors Complicating Subaortic Stenosis in Newborn Infants
Ji Seon Kang, Mi Jung Hwang, Tae Hyoung Cho, Byung Ju Kim, Young Jong Woo, Jae Sook Ma
Clin Exp Pediatr. 2000;43(8):1122-1126.   Published online August 15, 2000
The most common obstruction of left ventricular outflow in childhood is produced either by a fibrous ring below the aortic valve, or by localized or diffuse muscular hypertrophy of the interventricular septum. Cardiac tumors causing subaortic stenosis in the newborn infant are extremely rare. This report describes two cases of subaortic stenosis caused by a tumor of the left ventricle...
A Case of Korean Patient with Nonketotic Hyperglycinemia; Diagnosed Based on CSF Amino Acid Analysis and Magnetic Resonance Spectroscopy
Kie-Young Park, Ai-Rhan Kim, Ki-Soo Kim, Soo-Young Pi, Tae-Sung Ko, Jung-Hee Lee, Han-Wook Yoo
Clin Exp Pediatr. 2000;43(7):993-999.   Published online July 15, 2000
Nonketotic hyperglycinemia is an extremely rare congenital metabolic disorder, which is caused by the lack of a glycine cleavage system. The onset of hyperglycinemic symptom is during the neonatal or early infant period. Progressing grave neuromotor dysfunction is one of the main symptoms. They include myoclonic seizure, hiccup, apnea, decreased deep tendon reflex, lethargy and coma. The prognosis is mostly very poor. Furthermore, there...
Two Cases of Thin Basement Membrane Nephropathy presented with Minimal Change Nephrotic Syndrome
Young Mee Seo, Jae Gul Chung, En Sil Yu, Jin Yeong Jeong, Young Seo Park
Clin Exp Pediatr. 2000;43(7):978-982.   Published online July 15, 2000
Thin basement membrane nephropathy(TBMN) is defined histologically as follows : 1) By light microscopy only minor abnormalities are detected in the glomeruli at most minor mesangial widening. 2) By electron microscopy, diffuse thinning of glomerular basement membrane is demonstrated. 3) By immunofluorescence, absence of immunoglobulins and complement components is demonstrated. 4) Alport`s syndrome and systemic diseases that may affect the...
Original Article
A Study of Clinical Features of Acute Tumor Lysis Syndrome in Children
Ick-Jin Song, Young-Tak Lim
Clin Exp Pediatr. 2000;43(7):952-958.   Published online July 15, 2000
Purpose : Tumor lysis syndrome is characterized by hyperuricemia, hyperphosphatemia, hyperkalemia and hypocalcemia due to destruction of tumor cells. The purpose of this study is to estimate in children the incidence, onset time, differences in outcomes between hemodialysis and conservative therapy, and predictive factor of tumor lysis syndrome before treatment with chemotherapy. Methods : Subjects were 108 children who had received...
Natural History and Clinical Feature of Multicystic Dysplastic Kidney detected with Prenatal Ultrasonography
Young Lim Shin, Hye Sung Won, Jong Hyun Yoon, Young Seo Park
Clin Exp Pediatr. 2000;43(7):926-932.   Published online July 15, 2000
Purpose : Multicystic dysplastic kidney(MCDK) is characterized by the presence of multiple cysts of varying sizes. It is associated with ureteral or pelviureteral atresia, and a non-functioning kidney. The purpose of this study was to examine the clinical feature and the natural history of MCDK. Methods : A study was performed in 36 children with prenatal diagnosis of MCDK from 1989 to 1999. All...
Usefulness of Plasma Atrial Natriuretic Peptide Concentration in the Diagnosis of Patent Ductus Arteriosus in Preterm Infants
Byung Min Choi, Jae Kyun Yoon, Hyun Hee Lee, Hae Won Cheon, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 2000;43(7):897-904.   Published online July 15, 2000
Purpose : Diagnosis of a hemodynamically significant patent ductus arteriosus(PDA) that should be treated is difficult to determine by clinical and echocardiographic examinations. The aim of this study was to clarify the interrelationship of plasma atrial natriuretic peptide(ANP) concentrations and clinical signs or echocardiographic signs of PDA in preterm infants and use plasma ANP concentrations as a diagnostic indicator of a hemodynamically significant PDA. Methods...
Case Report
The Management of Three Infants with Critical Valvular Aortic Stenosis by Transcarotid Balloon Aortic Balvuloplasty
Kie-Young Park, Young-Hwue Kim, Ji-Yeon Min, Jae-Kon Ko, In-Sook Park, Chang-Yee Hong, Tae-Jin Yun, Dong-Man Seo
Clin Exp Pediatr. 2000;43(6):820-827.   Published online June 15, 2000
Critical valvular aortic stenosis(AS) is a life threatening congenital heart anomaly in neonates or infants. The main cause of death is rapidly progressing left ventricular failure. The treatment goal of critical AS is to save left ventricular function early. Before the 1980s, the preferred treatment was surgical valvotomy, however, that operative method had a high mortality rate and risk of...
Original Article
Mutations in Hepatitis B Virus Precore and Core Promotor in Children with Chronic Hepatitis B Infection - Comparison Between Vertical and Non-vertical Transmission -
Jin Kuk Kim, Yeong Hong Park, Woo Yeong Chung, Chul Ho Kim
Clin Exp Pediatr. 2000;43(6):779-791.   Published online June 15, 2000
Purpose : The aims of this study were to investigate the frequencies and role of hepatitis B virus(HBV) precore and core promotor mutations in children with chronic hepatitis B infection. Methods : Sera from 46 children with chronic hepatitis B infection were analyzed by direct sequencing of polymerase chain reaction product of HBV DNA. In this study, the patients were divided...
A Prospective Epidemiological Study on Birth Defects : A Community Based Pilot Study
Hyon Ju Kim, Yeon Kyeoung Kim, Dae Kyun Koh, Jong Hyun Kim, Bo Won Choi
Clin Exp Pediatr. 2000;43(6):738-745.   Published online June 15, 2000
Purpose : This prospective pilot study is a part of the Korean NIH’s effort to characterize congenital anomalies and genetic disorders in Korea and to establish a National Genetic Database. Methods : This population-based study was conducted at all hospitals that deliver in the province of Suwon; a total of 39 hospitals from May 1, 1997 to April 30, 1999 for...
Case Report
A Case of Neuromyelitis Opitica(Devic Disease)
Hee Taeg Kim, Yun Jong Kang
Clin Exp Pediatr. 2000;43(5):710-714.   Published online May 15, 2000
Neuromyelitis optica(Devic disease) is a rare demyelinating disorder of unknown etiology in which unilateral or bilateral optic neuritis and transverse myelitis occur within 8 weeks. The disease has no clinical involvement beyond the spinal cord or optic nerves. This illness occurs more commonly in adults than in children. The prognosis is better in children than in adults. The authors experienced...
Original Article
The Relation between Antibiotic Use and Changes of Antimicrobial Resistance of Gram Negative Bacilli Isolated in Chonbuk National University Hospital(1993-1997)
Min Ki Chang, Jung Min Chu, Hae Soo Lee, Jung Soo Kim
Clin Exp Pediatr. 2000;43(5):625-631.   Published online May 15, 2000
Purpose : Antimicrobial resistance has become a major medical and public health problem. This study was performed to evaluate the changes in antimicrobial susceptibility patterns. Methods : The susceptibility of 8,224 recent clinical isolates during a 5-year period from 1993 to 1997 were tested against 8 antimicrobial agents. Antimicrobial susceptibility test was performed by disc diffusion method. Results : E. coli...
Anticancer Effect of Arsenic Trioxide in Acute Promyelocytic Leukemia
Ki Young Song, Jin Hye Park, Yoon Jung Cho, Won Ki Baek, Ki Young Kwon, Heung Sik Kim, Chin Moo Kang
Clin Exp Pediatr. 2000;43(3):327-334.   Published online March 15, 2000
Purpose : Acute promyelocytic leukemia(APL or AML, M3) represents an unique model for cancer research in terms of biological and clinical features. Since 1988, it has been widely confirmed that all-trans retinoic acid(ATRA) can induce complete clinical remission in over 85% of APL patients by a differentiation process, with PML-RARα protein possibly being the direct target of ATRA. However, ATRA...
Case Report
A Case of Congenital Intrahepatic Portosystemic Venous Shunt
Do Yeon Kim, Dong Jin Lee, Jung Hyeok Kwon
Clin Exp Pediatr. 2000;43(2):283-287.   Published online February 15, 2000
Intrahepatic portosystemic venous shunt(IPVS) is an uncommon pathologic condition which occurs mostly in adult patients with portal hypertension and cirrhosis of the liver with only scattered reports are on children. However, asymptomatic IPVS have been detected in an increasing number of patients with recent advances in imaging techniques, such as sonography, CT, MR imaging, and color Doppler sonography. The cause...
A Case of Common Variable Immunodeficiency with Autoimmune Hemolytic Anemia
Kyung-Yil Lee, Yon-Joo Lee, Sang-Won Cha, Dong Joon Lee, Ji-Whan Han, Kyung-Tae Whang, Joong-Gon Kim
Clin Exp Pediatr. 2000;43(1):117-122.   Published online January 15, 2000
Common variable immunodeficiency(CVID) is a heterogeneous collection of disorders with hypogammaglobulinemia with recurrent bacterial infections and high incidence of autoimmune disorders as its hallmark. We report a 7-year-old girl suffering from CVID with Coombs' test positive hemolytic anemia. She had been relatively well until 23-months old when she was admitted to Taejon St. Mary' s Hospital with pneumonia 5 years ago. Afterwards, she had...
A Case of Retroperitoneal Cystic Lymphangioma
Chang Ho Lee, Jeong Hwa Choi, Eun Ju Han, Jin Gook Kim, Bung Do Nam, Jae Won Back, Mun Kyu Park
Clin Exp Pediatr. 2000;43(1):111-116.   Published online January 15, 2000
Cystic lymphangiomas are comparatively rare, benign tumors of lymphatic system and their histogenesis are uncertain. About 75% of theses lesions are in the neck, 20% are in the axillary region, and 5% are in the mediastinum, retroperitoneal region or groin. But retroperitoneal cysticlymphangiomas are very rare. Retroperitoneal cystic lymphangiomas are usually found incidentally during diagnostic procedures performed for unrelated clinical...
Original Article
A Catalogue of Gene Expression Difference in Biliary Cirrhosis due to Biliary Atresia Using Differential Expressed Sequence Tags(EST) Screening
Byung-Ho Choe, Hyun-Mi Lee, Moon-Kyu Kim, Jung-Chul Kim
Clin Exp Pediatr. 2000;43(1):60-69.   Published online January 15, 2000
Purpose : Extrahepatic biliary atresia is the most common indication for liver transplantation in children, but the etiology of this disorders remains unknown. It would be very signficant to identify genes that are specifically expressed in pathologic liver tissue of biliary atresia and analyze the pattern of expression in those genes. Methods : We made dot blot panels consisting of 1,730 different EST(expressed sequence...
Changes of Interleukin-10 and Granulocyte Colony-Stimulating Factor in Cerebrospinal Fluid of Children with Aseptic Meningitis
Byeong Chan Park, Jung-Yeon Shim, Jeong Mi Lee, Jin-Young Park, Myung Ja Yoon, Hye Rim Jung, Moon Soo Park, Dong Hyeuk Keum, Dong Keug Keum
Clin Exp Pediatr. 1999;42(12):1676-1682.   Published online December 15, 1999
Purpose : Interleukin(IL)-10 is an antiinflammatory cytokine produced by monocytes/macrophages. Granulocyte colony-stimulating factor(G-CSF) plays an important role, not only as a hemopoietic factor but also as a regulating factor for a biologic defense system by neutrophils, in the foci of infection. We studied G-CSF and IL-10 levels in the serum and cerebrospinal fluid(CSF) of patients with aseptic meningitis and investigated...
Clinical Evaluation of Diagnostic Criteria for Early Prediction of Bacterial Infection in Febrile Neonates
Jai Il Cho, Sang Chun Lee, Hwan Il Kim, Cheol Am Kim, Kil Seo Kim
Clin Exp Pediatr. 1999;42(12):1661-1667.   Published online December 15, 1999
Purpose : A retrospective study was undertaken to test the hypothesis that febrile neonates, who have bacterial infections, can be accurately predicted early by diagnostic criteria. Methods : We conducted a retrospective study of 152 infants, 28 days or less of age, whose rectal temperature was at least 38℃. Past history, family history, finding on physical examinations and results of CBC,...
A Study of Factors Affecting Time of First Stool in Premature Infants
Hyeong Doo Cho, Je Woo Kim, Young Ah Lee, Hae Sun Yoon
Clin Exp Pediatr. 1999;42(12):1645-1650.   Published online December 15, 1999
Purpose : To assess the effect of gestational age and illness severity, and the effect of antenatal exposure to magnesium sulfate, glucocorticoids, and antibiotics, on the timing of the first stool in preterm infants. Methods : Medical records of all preterm infants admitted to the neonatal ward at Kangnam Sacred Heart Hospital between March 1998 and August 1998 were reviewed. We...
Case Report
Dapsone in a Case with Chronic Recurrent Henoch-Schönlein Purpura
Jin Choi, Soo Jung Lee, Dae Kyun Koh
Clin Exp Pediatr. 1999;42(11):1574-1578.   Published online November 15, 1999
The most clearly delineated condition with prominent cutaneous leukocytoclastic vasculitis which presents to a pediatrician is Henoch-Schönlein purpura. There is general agreement that in Henoch-Schönlein syndrome the skin manifestations have a very benign long-term course and that corticosteroids are of little value. Dapsone appears to be of special value in diseases characterized by an accumulation of polymorphonuclear neutrophils notably leukocytoclastic...
Original Article
Side Effects of Antiepileptic Drug in Children
Ick-Jin Song, Sang-Ook Nam
Clin Exp Pediatr. 1999;42(11):1559-1566.   Published online November 15, 1999
Purpose : The purpose of this study is to estimate the side effects of antiepileptic drug(AED) in children. Methods : Subjects were 267 children who had received AED for at least 1 month during January 1995 to July 1998. We reviewed their sex, age at start of seizure onset, age at medication, class and number of AED, developmental delay, type and...
Case Report
A Case of Septic Arthritis due to Haemophilus influenzae associated with Atypical Kawasaki Disease
Sun Mi Yang, Jun Yun, Hea Kyoung Lee, Young Hee Yu, Hyun Sook Lee
Clin Exp Pediatr. 1999;42(10):1441-1445.   Published online October 15, 1999
We report a case of septic arthritis due to H. influenzae associated with atypical Kawasaki disease. A 2-year-old boy was admitted to our orthopedic department due to limping gait of the right leg. CT finding of right hip joint revealed fluid collection. He was diagnosed as transient synovitis and septic arthritis. He was treated with antibiotics, but no incision nor...
Original Article
Clinical Trends in Acute Rheumatic Fever in Korean Children : Mailed Questionnaire Survey from 1988 to 1997 (Compared with 1978-1987)
Hyeon-Ho Kang, Sung-Ho Cha, Kyong-Su Lee, Sang-Bum Lee, Tae-Chan Kwon, Young-Chang Tockgo, Chang-Sung Son, Jin-A Son, Hee-Ju Park, Yong-Soo Yun, Jung-Yun Choi, Chang-Hwi Kim, Chul-Ho Kim, Tai-Ju Hwang, Jae-Sook Ma, Chan-Uhng Joo, Nam-Su Kim
Clin Exp Pediatr. 1999;42(10):1381-1391.   Published online October 15, 1999
Purpose : The purpose of this study was to assess the frequency of acute rheumatic fever(ARF) among children in Korea and to describe trends in its clinical characteristics compared to data from a previous study(1978-1987). Methods : A mailed questionnaire survey sent to the pediatric departments of 13 general hospitals in Korea requested the total number of patients with ARF and...
Case Report
A Case of Rheumatic Fever Associated with Acute Poststreptococcal Glomerulonephritis
Jeong Kyung Seo, Un Seok Nho, Eun Jeong Kim, Chur Woo Yoo, Chul Kyu Kim
Clin Exp Pediatr. 1999;42(8):1170-1174.   Published online August 15, 1999
It is well known that both acute glomerulonephritis and rheumatic fever are a common sequelae of group A streptococcal infection. However, their simultaneous occurrence is uncommon. Only a few cases have been reported because they are different in epidemiologic, clinical, serologic and immunopathogenic characteristics. We experienced a 10-year-old boy who presented the manifestation of acute rheumatic fever and acute poststreptococcal...
Original Article
The Effects of Glutamate Receptor Antagonists on Cultured Cerebral Cortical Neurons of Neonatal Mouse Damaged by Oxidative Stress
Dae-ho Choi, Yeon-kyun Oh, Seung-taek Park
Clin Exp Pediatr. 1999;42(8):1096-1103.   Published online August 15, 1999
Purpose : To evaluate neurotoxic effects induced by oxygen-radicals, which were generated by adding xanthine oxidase(XO) and hypoxanthine(HX), and protective effects of glutamate receptor antagonist such as MK-801 and 6-cyano-7-nitroquinoxaline(CNQX). Methods : Dissociated cell cultures were prepared from cerebrum of neonatal mouse. Tissues were dissected and diced into small pieces in phosphate buffered saline and were incubated at 37℃. Isolated cells...
Effect of Antiepileptic Drugs on Bone Metabolism and Growth in Epileptic Children
Woo Suk Juhng, Sun Jun Kim, Soo Chul Cho, Chan Uhng Joo
Clin Exp Pediatr. 1999;42(8):1078-1085.   Published online August 15, 1999
Purpose : Long-term administration of anticonvulsants for children with convulsive disorder may cause osteomalacia, depending on dosage, duration, types, and combination of anticonvulsants administered. This study was performed to examine the effect of anticonvulsant drugs on bone mineral density in epileptic children. Methods : Forty-eight epileptic children aged 3 to 15 years were enrolled in this study. They were treated with...
Case Report
A Childhood Case of Nephrotic Syndrome Complicated with Cerebral Venous Sinus Thrombosis Followed by Left Popliteal Artery Thrombosis
Si-Eun Lee, Sue-Jin Lee, Yang-Suk Jung, Jae-Young Lim, Chan-Hoo Park, Hyang-Ok Woo, Jin-Jong Yoo, Hee-Shang Youn
Clin Exp Pediatr. 1999;42(7):1019-1025.   Published online July 15, 1999
We report a 10-year-old male with steroid-responsive nephrotic syndrome which was complicated by cerebral venous sinus thrombosis including superior sagittal sinus and left popliteal artery thrombosis following 5 months later. At each thrombotic episode, he suffered from relapse of massive proteinuria with hypovolemic crisis, and from hemoconcentration with dehydration due to vomiting or diarrhea. Brain MR angiography confirmed thromboses of...
A Case of Ectopic CD7(+) Congenital Monocytic Leukemia
Na Yeon Kim, Dong Seok Lee, Jin Hwa Jeong, Sung Min Cho, Doo Kwun Kim, Sung Min Choi, Woo Taek Kim, Kyung Im Ha
Clin Exp Pediatr. 1999;42(7):1003-1007.   Published online July 15, 1999
Congenital acute leukemia is a rare disorder with approximately 200 cases reported. It is defined as a childhood leukemia occurring at birth or before 1 month of age at a rate of 1%. Acute leukemias are generally classified according to morphology, cytochemistry and cell surface marker expression. Most leukemias conform to an ordered lineage-specific pattern of gene expression, but a...
Original Article
Clinical Study of Aseptic Meningitis from 1996 to 1998 in Chounju Presbyterian Medical Center, Korea
Seung Woo Paik, Byoung Lae O, Sun Ja Cho, Young Taek Chang
Clin Exp Pediatr. 1999;42(6):765-770.   Published online June 15, 1999
Purpose : There was an explosive prevalence of aseptic meningitis for three years from 1996 to 1998. In this study, we reported the time of outbreak, clinical manifestation, CSF examination of patient, and CSF virus culture. Methods : We reviewed clinical records of 794 aseptic meningitis patient who had been admitted to Chounju Presbyterian Medical Center. The total number of patients...
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