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Original Article
Elevated Circulating ICAM-1 and Eosinophil Cationic Protein in Children with Chronic Urticaria
You Sun Choi, Su A Shin, Young Dai Kim, Jae Won Oh, Ha Baik Lee
Clin Exp Pediatr. 2004;47(9):986-991.   Published online September 15, 2004
Purpose : Chronic urticaria is characterized by recurrent, itchy, and evanescent wheals over a period of six weeks. The mechanisms of chronic urticaria in children have not been fully elucidated. However, urticaria lesions represent a dynamic inflammatory process involving a complex interplay of various inflammatory mediators, chemokines, adhesion molecules and cellular interaction. The aim of this investigation was to elucidate...
Neurologic Complications after Hematopoietic Stem Cell Transplantation in Children
Moon Young Jeong, Young Kuk Cho, So Youn Kim, Young Ok Kim, Chan Jong Kim, Hoon Kook, Young Jong Woo, Tai Ju Hwang
Clin Exp Pediatr. 2004;47(9):978-985.   Published online September 15, 2004
Purpose : Neurologic complications(NC) after hematopoietic stem cell transplantation(HSCT) are important because of high mortality and severe sequelae. We analyzed the incidence, manifestation and risk factors of NC in 61 children undergoing HSCT. Methods : We retrospectively analyzed NC in 61 cases(42 male and 19 female, aged one to 16 years) given HSCT between 1996 and 2003 due to hematologic malignacies,...
Effects of the Chronic Use of Anticonvulsants on Bone Mineral Density in Children with Epilepsy
Hyun Hee Oh, You Cheol Jang, Byung Ho Choe, Il Hyung Park, Soon Hak Kwon
Clin Exp Pediatr. 2004;47(9):965-969.   Published online September 15, 2004
Purpose : Chronic administration of anticonvulsants for children with epilepsy may cause multiple abnormalities in bone metabolism. The aim of this study was to evaluate the effects of anticonvulsants on bone mineral density(BMD) in children with epilepsy. Methods : Seventy patients with epilepsy were enrolled in this study. All subjects had taken anticonvulsants for at least 1 year or more....
Case Report
A Case of Kikuchi-Fujimoto Disease, Subsequently Evolving to Systemic Lupus Eyrthematosus
Soon Hwa Yoon, Myoung Hoon Song, Seon Hee Shin, Sung Koo Kim, Kon Hee Lee, Hae Sun Yoon, Young Ok Jung, Hye Kyung Ahn
Clin Exp Pediatr. 2004;47(8):904-907.   Published online August 15, 2004
Kikuchi-Fujimoto disease(KFD), also known as histiocytic necrotizing lymphadenitis, is a self-limited systemic illness and it has the pathognomonic histological appearance of lymph nodes. KFD is rarely associated with systemic lupus erythematosus (SLE). The diagnosis of KFD can precede, postdate or coincide with the diagnosis of SLE. Our case describes a young woman, originally diagnosed as having Kikuchi's disease by lymph...
Original Article
Follow-up Studies and Clinical Significance of Chromosomal Rearrangement in Childhood Acute Lymphocytic Leukemia
Yang Hyun Kim, Jung Tae Kim, Jung Chul Kang, Hae Sik Kwon, Sung Chul Won, Seung Hwan Oh, Chuhl Joo Lyu
Clin Exp Pediatr. 2004;47(8):861-867.   Published online August 15, 2004
Purpose : Through routine screening for chromosomal defects present in patients with acute lymphocytic leukemia(ALL) by means of reverse transcription-polymerase chain reaction(RT-PCR), we aimed for earlier detection of recurrences, hence evaluating the progress of the disease after treatment, and forecasting the need for further testing. Methods : We analyzed 30 patients who visited the Pediatrics Department of Severance Hospital, from...
A Clinical Study of Infective Endocarditis in Childhood
Eun Na Choi, Jae Hun Kwon, Kyong Min Choi, Hwan Dae Hwang, Kyoung Mi Sin, Jae Young Choi, Jun Hee Sul, Dong Su Kim
Clin Exp Pediatr. 2004;47(8):844-850.   Published online August 15, 2004
Purpose : Advances in the treatment of congenital heart disease and a decline in the incidence of rheumatic fever has led to changes in the causative organisms and the clinical outcome of infective endocarditis(IE). We sought to analyze the clinical outcome, prognostic factors, causative organisms and corresponding antibiotic sensitivity in IE. Methods : Retrospective analysis of medical records of 104 children...
The Change in Intestinal Lactobacillus Count among Healthy Neonates
Hyun Joo Lee, Hyun Ji Lee, Su Jin Cho, Jung Wan Seo, Seung Joo Lee, Eun Ae Park
Clin Exp Pediatr. 2004;47(8):833-838.   Published online August 15, 2004
Purpose : Enhancing overall health by preventive and therapeutic use of probiotics has shown great promise on inflammatory, infectious, neoplastic disorders, allergies, et al. To attain preliminary data for the use of probiotics, we have studied the change in intestinal flora, Lactobacillus count among healthy, full term neonates. Methods : Fresh stool samples were collected on the 2nd or 5th day...
Clinical Lecture
The Pharmacotherapy of Childhood Epilepsy
Sang Ook Nam
Clin Exp Pediatr. 2004;47(8):821-826.   Published online August 15, 2004
Epilepsy is one of the most common and disabling neurologic disorders in childhood. The primary goal of epilepsy treatment is to choose the treatment modality that provides the best chance of improving the patient's quality of life. In addition to classic antiepileptic drugs, newly developed antiepileptic drugs ketogenic diet, epilepsy surgery, and vagal nerve stimulation have improved the ability to...
Medical Lecture Course
Impact of Host Genetics on Susceptibility and Outcome of Viral Infections
Eun Hwa Choi
Clin Exp Pediatr. 2004;47(8):815-820.   Published online August 15, 2004
The generation of a draft sequence of the human genome has lead to an opportunity to characterize human diversity, including the differences in host response to numerous pathogens. Host responses upon exposure to a pathogen can determine the wide spectrum of illness from subclinical or mild to severe diseases. Host factors, particularly genetic backgrounds, influence the pathogenesis of infectious diseases....
Original Article
Diagnostic Approach of Wiskott-Aldrich Syndrome
Dong Jin Hwang, Jun Won Yang, Sun Young Kim, Ho Keun Yi, Dae Yeol Lee, Pyoung Han Hwang
Clin Exp Pediatr. 2004;47(7):726-734.   Published online July 15, 2004
Objective : A probable diagnosis of Wiskott-Aldrich syndrome(WAS) should be considered in any boy presenting with unusual bleeding, congenital thrombocytopenia and small platelets. The definitive diagnosis of WAS is usually made by the detection of WASP gene mutation or a decrease or absence of the WAS protein(WASP) in blood cells using molecular genetic analysis. However, these methods are too time-consuming...
Clinical Lecture
Pathophysiology of Persistent Pulmonary Hypertension of the Newborn
Yong Hoon Jun
Clin Exp Pediatr. 2004;47(7):707-715.   Published online July 15, 2004
Persistent pulmonary hypertension of the newborn(PPHN) is a disorder characterized by persistence of the pattern of fetal circulation after birth due to a sustained elevation of pulmonary vascular resistance. The two primary events in the pathophysiology of neonatal pulmonary hypertension are hypoxic pulmonary vasoconstriction(HPV) and hypoxic pulmonary vascular remodeling(HPR). Chronic hypoxemia may cause increased muscularity of the pulmonary arteries and...
Original Article
Is Acute Nonspecific Mesenteric Lymphadenitis Associated with Acute Abdominal Pain in Epidemic Aseptic Meningitis?
Hae Rim Kim, Kiyoung Ku, Young Hwan Lee, Sin Kam, Jin-Bok Hwang
Clin Exp Pediatr. 2004;47(6):623-627.   Published online June 15, 2004
Purpose : Acute abdominal pain in an epidemic aseptic meningitis which is mostly an enterovirus as causative agent, is noted in 23-55% of patients. An enterovirus is also known as one of the causes of acute nonspecific mesenteric lymphadenitis(ANML). The purpose of this study was to see if ANML was associated with acute abdominal pain in epidemic aseptic meningitis. Methods :...
Case Report
A Case of Multiple Septic Arthritis by Streptococcus pneumoniae in Kawasaki Disease
Jae-Hoon Choe, In-Gyu Lee, Kyung-Bae Park, Joon-Soo Park, Young Chang Kim, Hwa-Yong Song, Byung-Heum Kim
Clin Exp Pediatr. 2004;47(5):579-582.   Published online May 15, 2004
In Kawasaki disease, arthritis may occur, generally affecting the hands, knees, ankles, or hips. Operations have not usually been needed. We report a case of Kawasaki Disease with multiple septic arthritis which was caused by S. pneumoniae and which needed athrotomy with drainage for both hips, both knees, and both ankle joints. A two year, ten-month-old girl was admitted to...
A Case of Tuberous Sclerosis associated with Abdominal Aneurysm
Eun Jeong Lee, So Jeong Yim, Sun Mi Kim, Dae Chul Jeong, Jin Han Kang, Seung Yun Chung
Clin Exp Pediatr. 2004;47(5):583-587.   Published online May 15, 2004
Tuberous sclerosis(TS) is known to be associated with multi-organ involvements, such as neurologic, renal and cardiac abnormalities. Abdominal aortic aneurysms in children and young adults are uncommon, however, some have been observed in patients with TS. We present an 8 month-old female patient with TS who developed aortic aneurysm and underwent successful surgical management. Since an aortic aneurysm is potentially...
Original Article
Aseptic Meningitis Secondary to High-Dose Intravenous Immunoglobulin Therapy in Kawasaki Disease
Ae Ra Cho, Jee Yoon Park, Kyung Hyo Kim, Young Mi Hong
Clin Exp Pediatr. 2004;47(5):561-566.   Published online May 15, 2004
Purpose : Kawasaki disease is a multisystemic inflammatory vasculitis and associated with neurologic features such as aseptic meningitis. High-dose intravenous immunoglobulin(IVIG) is used to treat Kawasaki disease and generally considered to be safe, but rare cases of aseptic meningitis with unknown etiology have been reported. The aseptic meningitis associated with Kawasaki disease was compared with meningitis as the adverse reaction...
Interpretation of Traumatic Lumbar Puncture in Aseptic Meningitis
Su Jin Sung, Jung Kim
Clin Exp Pediatr. 2004;47(5):543-546.   Published online May 15, 2004
Purpose : This study was undertaken to find out a useful method that can predict the true leukocytosis in blood-contaminated cerebrospinal fluid(CSF) due to traumatic lumbar puncture(LP), using white and red cell counts of sanguineous CSF and peripheral blood. Methods : From May 2001 to December 2002, among 1,247 patients presenting symptoms of meningitis who had received LP at Chonnam Hospital,...
Clinical and Virologic Study of Aseptic Meningitis
Hyun Ji Kim, Hae Kwan Cheong, Cheoll Jung, Kyu Man Lee, Young Mee Jee, Won Duck Kim, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi
Clin Exp Pediatr. 2004;47(4):392-398.   Published online April 15, 2004
Purpose : The cause of aseptic meningitis remains mostly unknown because viral culture and identification is difficult. Thus, we report a study on 123 children with aseptic meningitis in Gyeongju in 2002 to identify the causing virus and the relationship with the clinical manifestation. Methods : We prospectively investigated the patients, admitted to Dongguk University Hospital, into two groups between April...
Utility of Abdominal Computerized Tomography in Diagnosis of Acute Appendicitis
Su Jin Sung, Ji Young Yeoun, Seong Hoon Lee
Clin Exp Pediatr. 2004;47(3):290-293.   Published online March 15, 2004
Purpose : To evaluate the accuracy of ultrasonography(USG) and abdominal computerized tomography(CT) and the possibility of reducing unnecessary appendectomy rate with improvement of diagnostic accuracy using optional CT with USG. Methods : From January 1999 to May 2003, 496 patients younger than 14 years received surgical intervention with preoperative impression of acute appendicitis. They were devided into three groups no...
Risk Factors of Nephrocalcinosis in Very Low Birth Weight(VLBW) Infants
Gyu Hong Shim, Jin A Lee, Yun Jung Shin, Ee Kyung Kim, June Dong Park, Beyong Il Kim, Jung Hwan Choi
Clin Exp Pediatr. 2004;47(3):275-281.   Published online March 15, 2004
Purpose : Nephrocalcinosis in very low birth weight(VLBW) infants were known to be caused by a longer duration of furosemide use. However, etiologies, pathogenesis and risk factors remain unclear. Therefore, we examined the incidence and risk factors of nephrocalcinosis in VLBW infants retrospectively. Methods : Inborn babies of birth weights less than 1,500 gm were examined retrospectively. Data were reviewed on...
Case Report
A Case of Cutis Verticis Gyrata due to Cerebriform Intradermal Nevus in the Neonate
Hye Ryung Choi, Hyun Joo Lee, Eun Ae Park
Clin Exp Pediatr. 2004;47(2):223-226.   Published online February 15, 2004
Cutis verticis gyrata(CVG) is a morphologic syndrome of the scalp characterized by folds and furrows resembling the surface of brain. The primary form of cutis verticis gyrata is commonly associated with a neuropsychiatric condition and a secondary form occurs as a response of inflammatory or neoplastic process. The patient was a 1-day-old girl, who had a 15?1 cm sized, convoluted...
Atypical Hemolytic Uremic Syndrome Associated with Streptococcus pneumoniae Infection
Hyun Sug Lee, Ja Wook Koo, Sang Woo Kim, Hyun Soon Lee
Clin Exp Pediatr. 2004;47(2):217-222.   Published online February 15, 2004
Hemolytic uremic syndrome is the most common cause of acute renal failure in childhood. Atypical hemolytic uremic syndrome which is not usually associated with prodromal symptoms has a higher mortality rate and more tendency to progress to chronic renal failure. Children younger than two years of age are a more susceptible to pneumococcal infection and can develop more serious disease....
Original Article
Pharmacokinetics of Cyclosporine A and Its Therapeutic Effect in Children with Renal Diseases
Woo Sung Chun, Min-Soo Park, Jae Seung Lee, Juyun Yu, Moon Sung Park, Ki-Soo Pa
Clin Exp Pediatr. 2004;47(2):193-203.   Published online February 15, 2004
Purpose : To know the body handling properties and anti-proteinuric effect of cyclosporine A(CsA) in children with renal diseases, 34 patients with nephrotic syndrome or glomerular diseases were included to treatment trials and evaluated. Methods : Microemulsion formula CsA, 5 mg/kg/day was administered orally in two divided doses for 9.3?.6 months. Pharmacokinetic studies of CsA were done twice at beginning and...
Outcome after Discontinuation of Antiepileptic Drugs in Well Controlled Epileptic Children - Recurrence and Related Risk Factors
Hyo-Bin Kim, Su Jeong You, Tae-Sung Ko
Clin Exp Pediatr. 2004;47(1):66-75.   Published online January 15, 2004
Purpose : There has been no exact criteria established for when to discontinue antiepileptic drugs (AEDs) in epileptic children who had been well controlled for a long period. This study was undertaken to evaluate the recurrence rate and predictive risk factors of relapse after discontinuation of AEDs in epileptic children who had been seizure-free. Methods : We retrospectively studied 294 children...
Clinical Lecture
Continuous Renal Replacement Therapy in Pediatrics
Hyewon Hahn, Young Seo Park
Clin Exp Pediatr. 2004;47(1):1-5.   Published online January 15, 2004
Original Article
Effect of Delayed Intensification on Survival of Childhood Acute Lymphoblastic Leukemia
Jie Yeon Lee, Sue Youn, Byoung Chul Kwon, Chuhl Joo Lyu, Hwang Min Kim
Clin Exp Pediatr. 2003;46(12):1260-1265.   Published online December 15, 2003
Purpose : In 1970, the Berlin-Frankfurt-Munster(BFM) group introduced an intensification therapy after remission induction to reduce relapse of acute lymphoblastic leukemia(ALL) in childhood. Delayed intensification(DI) phase has been included for treatment of ALL in our hospital since the mid-1990s. The purpose of this study is to evaluate the outcome with vs. without DI phase and the outcome with two vs....
Comparison of the Characteristics of 16 Commercial Nebulizer/Compressor Combinations Used in Korea
Hyun Jung Kim, Cho Ae Lee, Eun Kyung Hwang, Man Young Han, Uk Sung Ann, Young Min Cho
Clin Exp Pediatr. 2003;46(12):1235-1241.   Published online December 15, 2003
Purpose : We assessed the dynamic characteristics of 16 nebulizer/compressor combinations currently available in Korea. Methods : The 16 nebulizer/compressor combinations(Pariboy Type 38/Long life, Pariboy Type N/ Long life, Pariboy Type N/Salter 8900, Pariboy Type N/LC, Devilbiss pulmoaid-LT/Hudson, Devilbiss pulmoaid/Hudson, Mesmed neb-300/Own, San-up 3040/Hudson, Midas(Basic)/Own, AirJolie 2/ Hudson, Thomas 1127/Salter 8900, Noel NE-2000/Salter 8900, Omron CX3/Hudson, Chang Woo CWN-100/Salter 8900, Voyage/Mefar,...
Case Report
Aplastic Crisis Secondary to Parvovirus B19 Infection
Yang Joon Park, Dae Kyun Koh, Jin Hee Oh
Clin Exp Pediatr. 2003;46(11):1139-1142.   Published online November 15, 2003
Human parvovirus(HPV) B19 infection causes erythema infectiosum in children, sometimes red cell aplastic crisis with hemolytic anemia and chronic bone marrow failure in immunocompromised hosts. HPV B19 is directly cytotoxic for erythroid progenitor cells and inhibits erythropoiesis. Infrequently, HPV B19 inhibits hematopoiesis of three cell lineages and causes transient pancytopenia in patients with hemolytic disorders. We report three patients with...
Original Article
A Clinical Study of Acute Colonic Diverticulitis in Children
Jae Hoon Sim, Keum Ho Song, Yun Jung Sim, Do Jun Cho, Dug Ha Kim, Ki Sik Min, Ki Yang Yoo, Hae Ran Lee, Kwan Seop Lee
Clin Exp Pediatr. 2003;46(11):1095-1100.   Published online November 15, 2003
Purpose : Children with acute colonic diverticulitis(ACD), can be misdiagnosed with acute appendicitis. Methods : We reviewed 15 cases of ACD during five years, from January 1998 to June 2002 retrospectively. Results : Most patients(80%) with ACD in children presented with right lower quadrant pain. The primary diagnosis on admission was mostly acute appendicitis(87%), and all ACD in children occurred in...
Case Report
A Case of Hemophagocytic Lymphohistiocytosis in a Child with Systemic Lupus Erythematosus
Ja Young Hwang, Suk Man No, Jin Lee, Pil Sang Jang, Young Hoon Kim, Jin Tack Kim, Joon Sung Lee
Clin Exp Pediatr. 2003;46(10):1029-1031.   Published online October 15, 2003
Hemophagocytic lymphohistiocytosis is a reactive disorder characterized by a generalized non-malignant histiocytic proliferation with prominent hemophagocytosis by stimulated histiocytes in the bone marrow and reticuloendothelial systems resulting in pancytopenia and liver dysfunction. Several diseases including infection, malignancy and autoimmune disease are known to be causative disorders. This case demonstrated histiocytic hemophagocytosis in the bone marrow, resulting in pancytopenia during treatment...
A Case of Canavan Disease
Young Ho Son, Tae Gyu Hwang, Jong Beom Sinn
Clin Exp Pediatr. 2003;46(9):934-938.   Published online September 15, 2003
Canavan disease, also known as van Bogaert-Bertrand disease, is a rare autosomal recessive disorder characterized by early an onset and a progressive spongyform degeneration of the brain, associated with an edema of the central nerve system, intramyelinic swelling and neurologic symptoms. This disorder is most prevalent in people of Ashkenazi Jewish descent but has been observed in other ethnic groups....
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