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Original Article
Characteristics of Insulin-Like Growth Factor I in Serum; Pattern of Insulin-Like Growth Factor Binding Protein (Large Complex) in Short Stature Patients with Complete Growth Hormone Deficiency
Jin Nyoung Park, Byung Deok Seo, Jeh Hoon Shin, Soo Ji Moon, Sung Yeoul Chang
Clin Exp Pediatr. 1994;37(11):1548-1559.   Published online November 15, 1994
To elucidate the complex of insulin-like growth factor binding proteins (IGF-BPs) in short stature patients, we carried out a prospective study on three patients who were diagnosed as complete GH deficiency at the department of pediatrics form July 1992 to June 1993. The results were summarized as follows: 1) Two circulating IGFs complexed to specific binding protein existed in normal serum. Binding...
Antilymphocyte Globulin Therapy for Aplastic Anemia in Children
Soo Jong Hong, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1994;37(11):1526-1539.   Published online November 15, 1994
Immunosuppressive therapy based on the use of antilymphocyte globulin (ALG) has become standard therapy for patients with aplastic anemia who are not eligible for bone marrow transplantation. In this study, T cell subsets before and after ALG therapy, hematologic responses, complications and prognostic factors were analysed. Eleven (42%) out of twenty-six patients treated with ALG showed response, but...
The Growth Hormone-Binding Proteins in Human Serum: Partial characterization and Regulation
Ji Young Suh, Bu Hun Lee, Jeh Hoon Shin, Hang Lee, Seong Ryul Jang
Clin Exp Pediatr. 1994;37(10):1427-1436.   Published online October 15, 1994
We assessed abotu growth homone binding proteins(GHP|BP) activity which was measured eluted biotin GH fraction with alkaline phosphatase-streptavidine in children with insulin dependent diabetes mellitus(IDDM), short stature due to growth hormone deficiency(GHD), chronic renal failure, short stature due to nutritional deficiency. Hypothyroidism, and noraml control groups using high pressure liquid chromatography protein pak 300 sw column. The following results are observed: 1)...
Studies on the B Cell Proliferation and Differentiation Factors in Human B Cell System
Kwang-Ju Lee, Young-Hun Chung, Jae-Ho Lee
Clin Exp Pediatr. 1994;37(10):1386-1396.   Published online October 15, 1994
We have studied the function of lymphokines on human tonsillar B cell proliferation and differentiation. B cells were stimulated with Staphylococcus aureus Cowan1(SAC) or anti-μ bead. The followings showed the results of this study. 1) In B cell activation, SAC induced B cell DNA synthesis but anti-μ bead did not. SAC could activate and proliferate B cells. Minimal number of B cells...
Case Report
A Case of Anti-Neutrophil Cytoplasmic Antibodies (ANCA) Positive Wegener's Granulomatosis
Won Tae Kim, Woo Jeong Kim, Joon Sik Kim, Chin Moon Kang, Kwan Kyu Park
Clin Exp Pediatr. 1994;37(8):1175-1181.   Published online August 15, 1994
Wegener's granulomatosis is a disease of unknown etiology that is characterized by the clinicopathologic complex of necrotizing granulomatous vasculitis of the upper and lower respiratory tract, glomerulonephritis, and variable degrees of small vessel vasculitis. Recently Antineutrophil Cytoplasmic Antibody (ANCA) has been reported to be a highly specific test for the diagnosis of Wegener's granulomatosis. We have experienced a patient of Wegener's...
Original Article
A Study on Evolution of Lipoportein(a) in Newborns
Keun Haeng Cho, Young Sook Hong, Soo Won Lee, Soon Kyum Kim, Young Chang Tockgo, Han Kyeom Kim
Clin Exp Pediatr. 1994;37(8):1078-1091.   Published online August 15, 1994
Lipoprotein(a) [Lp(a)] is considered an additional, independent and largely genetically determined risk factor for the development of premature coronary heart disease. Furthermore abnormal plasma lipoprotein patterns have been associated with increased risk for developing coronary heart disease. Among these lipoproteins, an increased concentration of serum Apo B and decreased level of Apo A are considered as major risk factors, together...
Significance of Urinary Interleukin 6 Level in Mesangial Proliferative Glomerulonephritis in Children
Byeong Ho Kang, No Hyun Kim, Woo Yeong Chung, Chul Ho Kim, Soon Yong Lee
Clin Exp Pediatr. 1994;37(7):900-905.   Published online July 15, 1994
By animal experiments in rat, it has been known that Interleukin-6(IL-6) is secreted from renal mesangial cells and is an autocrine growth factor for the proliferation of mesangial cells. According to these facts, several studies have been tried for its clinical usefulness by measuring their serum or urinary IL-6 in glomerulonephritis patients with mesangial proliferation. The authors measured urinary IL-6...
Case Report
A Case of Synophthalmia with Chromosomal Anomaly: 46,XX,-15,t(15q,21q)
Byung Moon Ahn, Woo Seog Kim, Moo Yung Song, Un Jun Hyoung, Jin Oh Lee
Clin Exp Pediatr. 1994;37(6):854-860.   Published online June 15, 1994
A synophthalmia, another form of cyclopia, in which the element of the two eyes are partially fused to form an apparently single eye in the middle of the forehead. The synophthalmia is a result of complex, neural plate misdevelopment syndrome involving the eye, brain, skull and face. It is well known that synophthalmia is due to heterogenous causes, most of...
A Case of Congenital Hypoprothrombinemia
Jong Kwang Lee, Hae Won Cheon, Jung Hwa Lee, Kwang Chul Lee, Soon Kyum Kim
Clin Exp Pediatr. 1994;37(3):422-429.   Published online March 15, 1994
Congenital hypoprothrombinemia is a rare congenital coagulation defect. The clinical signs are manifestation of generalized bleeding tendency such as; mucosal bleeding, hypermenorrhea and post tooth extraction hemorrage. It is associated with prolongation of PT and PTT with normal thrombin time and decreased serum prothrombin level. A case with congenital hypoprothrombinemia was experienced by the authors. A 36 days old male baby...
Original Article
Eosinophil Cationic Protein in Relation to Bronchial Hyperresponsiveness in Asthmatic Children
Jin Tack Kim, Joon Sung Lee
Clin Exp Pediatr. 1993;36(12):1707-1715.   Published online December 15, 1993
The eosinophil is the major cell responsible for the inflammatory reaction in bronchial asthma. Secretion of granular components is probably of considerable importance for the inflammatory effects of the eosinophils, Eosinophil cationic protein (ECP) is the one of the secretory components of the eosinophil granule and is considered as an activation marker of eosinophil, Blood eosinophil count, serum concentration of...
Esophageal Varix in Children - Endoscopic Evaluation and Clinical characteristics-
Soon Young Kim, Jeong Kee Seo
Clin Exp Pediatr. 1993;36(12):1691-1700.   Published online December 15, 1993
Fifty five children with encoscopically proven esophageal varices form Jul. 1987 to Dec. 1992 were analyzed for endoscopic and clinical characteristics. The results were as follows : 1) According to etiological classification of portal hypertension in 55 cases, 35 cases showed intrahepatic causes (64%) and cases had extrahepatic causes (36%). The most common clinical manifestation on admission was hematemesis (42%) and abdominal mass...
Cow Milk Allergy in Infant Who Neonatal Onset
Seung Hee Park, Myung Ik Lee, Don Hee Ahn, Seung Hee Park
Clin Exp Pediatr. 1993;36(10):1383-1388.   Published online October 15, 1993
Cow milk allergy can be defined as an adverse immunologic reactions to cow milk protein. The term is often mistakenly applied to other causes of milk intolerence, such as lactase deficiency and galactosemia, which must be differenciated and excluded. We have experienced 10 children of cow milk allergy at neonatal onset who had suffered from G-I symtons, such as diarrhea, irritability,...
Effect of Different Levels of the Dietary Protein on Long Term Prognosis of Experimental Renal Damage
Choon Haeng Lee, Sang Joo Han, Hong Jin Lee, Won Il Park, Kyung Ja Lee, Young Eui Park, Min Chul Lee, Tae Heon Yoon
Clin Exp Pediatr. 1993;36(6):820-829.   Published online June 15, 1993
We examined the effect of various levels of dietary protein on long term prognosis of Adriamycinephropathy of S-D rat, fed with high protein(30%), intermediately low(10%), and strictly low(5%) protein diet for 15 weeks 1) In rats fed with strictly low protein diets(5%), proteinuria and serum creatinine decreased and creatinine clearance and histological changes were relatively well preserved. But hypoproteinmia and weight...
Serum Eosinophil Cationic Protien(ECP) in Children with Atopic Astham
Dae Cheol Kim, Ha Baik Lee
Clin Exp Pediatr. 1993;36(6):810-819.   Published online June 15, 1993
Eosinophils play a major role in the airway inflammation in asthma. To werify an association between airway responsiveness of asthmatics and eosinophil and/or ECP, we measured serum ECP in 23 children with atopic asthma during acute attacks and stable, and in 10 normal healthy controls. Peak flows were monitored in 15 children. The data suggest that serum ECP levels were higher...
The Usefulness of Measuring Serum α-fetoprotein and Thyroxine-binding Globulin to Differentiate between Neonatal Hepatitis and Congenital Extrahepatic Biliary Atresia
Soo Kyoung Lee, Ki Sup Chung
Clin Exp Pediatr. 1993;36(4):512-520.   Published online April 15, 1993
Together, neonatal hepatitis and biliary atresia make up approximately 70 to 80% of the causes of neonatal cholestasis. Biliary atresia must be differentiated from neonatal hepatitis as soon as possible in order to institute early surgical intervention. We performed this study to examine whether the measurement of the serum α-fetoprotein(AFP) and thyroxine-binding globulin(TBG) was useful for differentiating these two conditions....
Case Report
Characterization of the Novel Late T Cell Activation Proteins, 519 and 520
Dae-Yeol Lee, Alan M Krensky
Clin Exp Pediatr. 1993;36(3):409-416.   Published online March 15, 1993
The late T cell activation gene, 519, is expressed in antigen specific, growth factor dependent T cell lines and clones but not in T or B cell tumors, other hematopoietic cells, tonsil, muscle, lung, or liver. Resting peripheral blood ymphocytes(PBLs)express little or no 519mRNA, but levels increase dramatically 5~7 days after activation with alloantigen or mitoen. Four alternatively spliced transcripts...
Original Article
A Study of Valproic Acid Therapy in Epileptic Children
Hae Jin Choi, Keon Su Rhee
Clin Exp Pediatr. 1993;36(3):328-337.   Published online March 15, 1993
A study was made on 50 cases of epileptic children who had been observed at the pediatric department of Chungnam National University Hospital and Taejeon Eul Ji Hospital during the period from July, 1986 to June, 1991 The result are as follows : 1) Epilepsy was most frequent in children from 1 yar to 10 year of age(80%). Epilepsy was commoner in...
Case Report
A Case of Intestinal Lymphangiectasia
Yae Kyung Suh, Kyung Hee Park, Chul Ho Jang, Bum Soo Park, Jeong Kee Seo, Sung Hae Park, Je Geun Chi, Kyung Mo Yeon, Kwi Won Park
Clin Exp Pediatr. 1992;35(12):1737-1743.   Published online December 15, 1992
Intestinal lymphangiectasia is a primary or secondary disorder of the gastrointestinal tract, which is associated with lymphatic dysfuction and protein-losing enteropathy. It's clinical manifestations vary widely, but the main symptoms are abdominal distention, edema, abdominal pain and growth failure. We described a 15-yr-old boy, who suffered from above symptoms since third year of his age and diagnosed by duodenal endoscopy which...
Original Article
Septicemia in Children with Neoplastic Disease
Bo Young Yun, Hoan Jong Lee
Clin Exp Pediatr. 1992;35(11):1481-1492.   Published online November 15, 1992
This study reviewed 66 episodes of septicemia occurring in 56 children with neoplastic disease at Seoul National University Children뭩 hospital over 31 month period. The most frequent organisms causing 45 episodes in neutropenic patient were Escherichia coli (28%), Klebsiella species (18%), Pseudomonas species (9%), polymicrobic (9%,), and Staphylococcus aureus (7%). The overal mortality was 13% (5/39). The most frequent organisms...
Case Report
A Case of Fukuyama Type Congenital Muscular Dystrophy
Young Eun Lee, Min Hyea Kim, Keun Lee, Eun Chul Chung, Hyea Soo Koo
Clin Exp Pediatr. 1992;35(10):1463-1468.   Published online October 15, 1992
Fukuyama type congenital muscular dystrophy is characterized by mental retardation, progressive muscle weakness and hypotonia, joint contracture and seizures in half of the reported cases. The usual CT abnormalities are dilated cerebral ventricles and Sylvian fissures and lucency of cortical white matter. The most consistent pathologic findings in the brain are polymicrogyria and pachygyria, caused by a disturbance of migration...
Three Cases of Listeria Infection in the Immunocompromised Children
Mee Ran Kim, Bo Young Yun, Hye Young Kang, Sung Hee Jang, Hoan Jong Lee, Yong Seung Hwang, Eui Chong Kim
Clin Exp Pediatr. 1992;35(10):1419-1426.   Published online October 15, 1992
Infection by Listeria monocytogenes, an uncommon pathogen in immunocompromised host, has been reported in neonates, pregnant women and adults with defective cell mediated immunity but not in children in Korea. It can cause sepsis, meningitis, abortion, premature labor, intrauterine fetal infection. etc. We have experienced L. monocytogenes sepsis and/or meningitis in three children under immunosuppresive therapy for lymphoma-leukemia, cytophagic histiocytic...
Primay Endodermal Sinus Tumor of the Common Bile Duct
Kyeong Hee Cho, Se Jung Sohn, Kil Hyun Kim, Hak Soo Lee
Clin Exp Pediatr. 1992;35(9):1298-1302.   Published online September 15, 1992
The endodermal sinus tumors are rare and highly malignant germ cell origin tumors occuring in both gonadal and extragonadal tissue. We have experienced a case of endodermal sinus tumor mixed with benign teratoma occuring in the common bile duct. It is a very rare site for endodermal sinus tumor. Serum α-fetoprotein was well correlated with clinical course.
Hutchinson-Gilford Progeria Syndrome
Moon Whan Lee, Byoung Geun Lee, Pyung Han Hwang, Dae Yeol Lee, Jung Soo Kim
Clin Exp Pediatr. 1992;35(7):971-977.   Published online July 15, 1992
Hutchinson-Gilford Progeria Syndrome is an extremely rare condition that was initially reported by Jonathan Hutchinson in 1886 and further described by Hastings Gilford in 1904. Clinical manifestations are evident by the first or second year of life with the physical characteris-tics of the elderly. Progeric patients ordinarily develop atherosclerosis and die of cardiac or cerebral vascular disease between 7 and 27...
Neonatal Purpura Fulminans due to Homozygous Protein C Deficiency
Jae-Hong Park, Sung-Sub Sim, Soo-Young Kim, Hee-Joo Jeon, Chan-Yung Kim, Hong Keun Oh, Jin-Yeong Jeong
Clin Exp Pediatr. 1992;35(5):696-703.   Published online May 15, 1992
Homozygous protein C deficiency is a rare herediatary disorder of blood coagulation resulting in microvascular and venous thromboses, usually purpura fulminans, starting shortly after birth. Protein C serves to inactivate the active forms of factor V and VIII, and increase the rate of fibrin degradation. For confirmation of homozygous protein C deficiency, the infant should have undetectable protein...
Original Article
Clinical Observation of Meconium Aspiration Syndrome: Prognostic Implication of Early Meconium Suctioning
Dae Hyun Kim, Dong Hoon Ko, Young Jong Woo, Young Youn Choi, Tae Ju Hwang
Clin Exp Pediatr. 1992;35(4):484-491.   Published online April 15, 1992
The authors observed the clinical findings of 36 patients with meconium aspiration syndrome(MAS) to evaluate the effect of early appropriated meconium suctioning on the morbidity and mortality of the syndrome. Patients in the study group, 20 babies born in Chonnam university Hospital, received appropriate meconium suction through endotracheal tube during and rig-ht after the delivery, while the patients in the...
Case Report
A Case of Holoprosencephaly, Alobar Type
Kyu Sun CHoi, Kang Seo Park, Young Tack Jang, Wan Seob Kim
Clin Exp Pediatr. 1992;35(3):390-394.   Published online March 15, 1992
A case of Holoprosencephaly, alobar type , was presented here and 13-month follow-up has been made. He had dyspnea, polikilothermia, frequent atypical seizures, hypernatremia & pitressinresponsive Diabetes insipidus as clinical manifeststions. Chromosome studies showed normal male karyotype (46XY). The diagnosis was confirmed by brain CT scan. A brief review of the related literature was made.
Original Article
The Effect of Prostaglandin E1 Infusion for Palliation of Ductus Dependent Cyanotic Congenital Heart Disease in Neonates
Ji Hee Park, Chang Sung Son, Joo Won Lee, Young Chang Tockgo
Clin Exp Pediatr. 1992;35(3):364-370.   Published online March 15, 1992
Prostaglandin E1 (PGE1) was administered to 12 neonates with cyanotic congenital heart disease in whom pulmonary or systemic blood flow were entirely or significantly dependent on persistent patency of the ductus arteriosus. 10 neonates responded favorably to PGE1, by showing significant increase of PaO2 after PGE1 infusion but remaining 2 neonates with hypoplastic left heart syndrome failed to respond. The...
A case of transient myeloproliferative disorder in Down's syndrome.
Dong Uk Kim, Woo Ki Lee, Eung Won Park, Kwang Woo Kim
Clin Exp Pediatr. 1991;34(12):1740-1744.   Published online December 31, 1991
Transient myeloproliferative disorder has been reported in infants with Down’s syndrome. This disorder is clinically and hematologically indistinguishable from congenital leukemia. In contrast to congenital leukemia, complete clinical and hematological recovery occurs within weeks to months of diagnosis without antileukemic treatment. We experienced a case of Transient myeloproliferative disorder with Down’s syndrome. This 4-day-old female neonate showed jaundice, hepatomegaly, fever, dyspnea, mongoloid face and congenital heart...
A case of holoprosencephaly.
Jin Eun Hyun, Eun Hee Park, Hee Young Jeon, Whwa Jin Byeun, Young Mok Hwang, Yeon Jin Kim, Cheol Soo Kim
Clin Exp Pediatr. 1991;34(12):1712-1716.   Published online December 31, 1991
Holoprosencephaly is a congenital malformation complex involving developmental failure in normal cleavage of the forebrain into hemispheres and varying degrees of median facial deformities. We experienced a case of lobar holoprosencephaly in a one day old girl who showed median facial deformities and reviewed the references concerning holoprosencephaly briefly.
The effects of 1800 vGy cranial irradiation on intellectual function of children with acute lymphocytic leukemia.
Soo Ho Ahn, Jeong Ok Hah, Jung Hoon Lee
Clin Exp Pediatr. 1991;34(12):1683-1688.   Published online December 31, 1991
This study was conducted to investigate the effects of CNS prophylaxis with 1800 cGy cranial irradiation and intrathecal methotrexate (MTX) chemotherapy on intellectual function of the chil- dren with acute lymphocytic leukemia (ALL). Thirteen longterm survivors with ALL who were treated with 1800 cGy cranial irradiation and intrathecal MTX for CNS prophylaxis at pediatric department of Yeungnam University Hospital from May, 1983 to November, 1988...
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