| Studies on the B Cell Proliferation and Differentiation Factors in Human B Cell System |
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Kwang-Ju Lee, Young-Hun Chung, Jae-Ho Lee |
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Department of Pediatrics, College of Medicine, Chungnam National University, Taejeon, Korea |
| 인간의 B세포 증식과 분화에 작용하는 인자들에 대한 연구 |
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이광주, 정용헌, 이재호 |
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충남대학교 의과대학 소아과학교실 |
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| Abstract |
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We have studied the function of lymphokines on human tonsillar B cell proliferation and differentiation. B cells were stimulated with Staphylococcus aureus Cowan1(SAC) or anti-μ bead.
The followings showed the results of this study.
1) In B cell activation, SAC induced B cell DNA synthesis but anti-μ bead did not. SAC could activate and proliferate B cells. Minimal number of B cells were required to proliferate effectively.
2) In B cell proliferation, SAC could proliferate B cell in the abscence of lymphokines. Exogenous IL-2 or IL-4 enhance B cell proliferation. The roles of IL-2 were very important in B cell proliferation. The effect of IL-4 on the IL-2 induced B cell proliferation was inhibitory in SAC-B cells IL-4 could enhance the proliferation of anti-μ bead activated B cells.
3) In B cell differentiation, IL-2 was a major factor to differentiate SAC activated B cells, but IL-4 did not. IL-6 had a synergistic effect on the differentiation.
The results of this study showed that the different signal transduction mechanisms were involved in B cell proliferation and differentiation. The B cell resposes to lymphokine were different, and it is depend upon antigens or mitogens. |
| Key Words:
B cell, Proliferation, Differentiation, BCGF , BCDF |
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